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Abstract
Purpose
To analyze the relationships between homocysteine, folate, MTHFR and TSER polymorphism for postmenopausal women with osteoporotic compression fractures.
Materials and Methods
Forty-three postmenopausal compression fracture patients and as many normal controls were included. The plasma homocysteine and folate levels were measured using a FPIA (fluorescent polarizing immunoassay) kit. The MTHFR and TSER genotypes were amplified by PCR (polymerase chain reaction) and separated by RFLP (restriction fragment length polymorphism) in a 3.5% agarose gel.
Figures and Tables
Table 1
Baseline Characteristics in the Postmenopausal Compression Fracture Patients and Control Subjects
Table 2
MTHFR C677T Genotype Distributions in the Postmenopausal Compression Fracture Patients and Control Subjects TESR
Table 3
TSER Genotype Distributions in the Postmenopausal Compression Fracture Patients and Control Subjects
Table 4
Plasma Folate Levels in the Postmenopausal Compression Fracture Patients and Control Subjects according to the MTHFR C677T Genotype
Table 5
Plasma Homocysteine Levels in the Postmenopausal Compression Fracture Patients and Control Subjects according to the MTHFR C667T Genotype
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