Smoking, Alcohol Intake and the Risk of Dupuytren's Disease in Koreans

Soo Bong Hahn; Ho Jung Kang; Seung Hwan Lee; Hong Kyun Kim

doi:10.4055/jkoa.2007.42.3.305

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Hahn, Kang, Lee, and Kim: Smoking, Alcohol Intake and the Risk of Dupuytren's Disease in Koreans

Original Article

Journal of the Korean Orthopaedic Association

Journal of the Korean Orthopaedic Association 2007; 42(3): 305-309.

Published online: 30 June 2007

DOI: https://doi.org/10.4055/jkoa.2007.42.3.305

Smoking, Alcohol Intake and the Risk of Dupuytren's Disease in Koreans

Soo Bong Hahn, M.D., Ho Jung Kang, M.D., Seung Hwan Lee, M.D., Hong Kyun Kim, M.D.

Department of Orthopedic Surgery, Yonsei University College of Medicine, Seoul, Korea.

Address reprint requests to Soo Bong Hahn, M.D. Department of Orthopaedic Surgery, Severance Hospital, Yonsei University College of Medicine, 134, Sinchon-dong, Seodaemun-gu, Seoul 120-752, Korea. Tel: +82.2-2228-2180, Fax: +82.2-363-1139, sbhahn@yumc.yonsei.ac.kr

Abstract

Purpose

This study evaluated the relationship between Dupuytrens disease and smoking and alcohol intake.

Materials and Methods

Forty eight patients with Dupuytrens disease, who underwent a partial fasiectomy were examined retrospectively through a chart review and a telephone interview. The minimum follow-up period was 12 months. The relationship between Dupuytren's disease and smoking and alcohol intake were analyzed using multivariate logistic regression with significance set at p<0.05.

Results

Dupuytren's disease requiring surgery in these patients was associated with heavy alcohol intake (odds ratio 2.91) and alcohol intake per week (odds ratio 1.22). The average smoking level was 24.7 pack-year for cases compared with 16.1 pack-year for controls (p<0.05). The average alcohol intake was 3.0 units per week for the cases compared with 1.2 units per week for controls (p<0.05). Smoking was not an independent risk factor but increased the risk when combined with heavy alcohol intake.

Conclusion

Heavy alcohol intake is an independent risk factor of Dupuytren's disease in Korean. Smoking is not an independent risk factor but increases the risk when combined with heavy alcohol intake.

Keywords: Dupuytren, Smoking, Alcohol

Figures and Tables

Table 1

Number of Smokers and Heavy Alcohol Consumers

Chi-square test. p<0.05.

Table 2

Average Smoking and Alcohol Intake

Chi-square test. p<0.05.

Table 3

Multivariate Logistic Regression Analysis with Discrete Variables (Smoker, Heavy Alcohol Consumer)

Reported as odds ratios with 95% confidence limits in parentheses.

Table 4

Multivariate Logistic Regression Analysis with the Continuous Variables (Smoking, Alcohol Intake)

Reported as odds ratios with the 95% confidence limits in parentheses.

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