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Kim, Chang, Jang, Lee, Bahk, In, and Yoon: Bone Formation of Cultured Osteoblasts in Bone Defect of Radial Shaft of Rabbit
Original Article

Journal of the Korean Orthopaedic Association 2005; 40(1): 76-82.

Published online: 28 December 2017

DOI: https://doi.org/10.4055/jkoa.2005.40.1.76

Bone Formation of Cultured Osteoblasts in Bone Defect of Radial Shaft of Rabbit

Seok Jung Kim, Cheong Ho Chang, Jae Deog Jang, Seung Koo Lee, Won Jong Bahk, Yong In, Hyung Moon Yoon

Department of Orthopedic Surgery, Uijeongbu St. Mary's Hospital, The Catholic University of Korea, College of Medicine, Seoul, Korea.

Central Research Institute, Cellontech, Seoul, Korea.

iy1000@catholic.ac.kr

Copyright © 2005 The Korean Orthopaedic Association

Abstract

Purpose

To evaluate the osteogenic potential of an autologous cultured osteoblast transplant to the bone defects.

Materials and Methods

Radial bone defects over 15 mm were made in 20 New Zealand white rabbits using the anterior approach. There were 10 rabbits in the control group, which underwent an iliac bone graft to the preformed bone defect 3 weeks from the initial operation. There were 10 rabbits in the experimental group that underwent an autologous cultured osteoblasts injection. After 9 weeks, both groups were compared radiologically and histologically.

Results

The osteogenesis in both groups were progressed similarly and there was no difference in terms of the amount of bone formation and the duration of the bone union.

Conclusion

An autologous cultured osteoblast transplant to the bone defect produces bone efficiently.In addition, it can be applied to a wide field, which requires a bone grafting operation.

Keywords: Bone defect, Autologous cultured osteoblasts transplantation, Bone formation

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