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Ryu, Rhee, and Jahng: Investigation of Correlations of Double Inversion Recovery and MR Spectroscopy on Breast MR Imaging
Original Article

Journal of the Korean Society of Magnetic Resonance in Medicine 2014; 18(1): 34-42.

Published online: 26 March 2014

DOI: https://doi.org/10.13104/jksmrm.2014.18.1.34

Investigation of Correlations of Double Inversion Recovery and MR Spectroscopy on Breast MR Imaging

Jung Kyu Ryu, Sun Jung Rhee, Geon-Ho Jahng

Department of Radiology, Kyung Hee University Hospital at Gandong, College of Medicine, Kyung Hee University, Korea.

Address reprint requests to: Geon-Ho Jahng, Ph.D., Department of Radiology, Kyung Hee University Hospital at Gandong, 892 Dongnam-ro, Gangdong-gu, Seoul 134-727, Korea. Tel. 82-2-440-6187, Fax. 82-2-440-6932, ghjahng@gmail.com

Received 3 February 2014       Revised 12 March 2014       Accepted 12 March 2014

Copyright © 2014 Journal of the Korean Society of Magnetic Resonance in Medicine

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

To evaluate the correlation of lesion-to-normal ratio (LNR) of signal intensity from double inversion recovery MR imaging and total choline-containing compound (tCho) resonance from single voxel MR spectroscopy in breast cancers.

Materials and Methods

Between August 2008 and December 2009, 28 patients who were diagnosed as breast cancer and had undergone both double inversion recovery (DIR) MR imaging and MR spectroscopy (MRS) were included in this study. The signal intensities of the lesion (L) and ipsilateral normal breast tissue (N) were measured in region of interest of each breast cancer in DIR and contrast enhance MR image (CE-T1WI) to calculate the LNR value for each technique. MRS was performed using single-voxel MR spectroscopy. The height, width and area of tCho resonance were compared with each LNR of DIR and CE-T1WI. We used Pearson's correlation coefficient (r) for correlation analysis and the significance level was p=0.05.

Results

There was no statistically significant correlation between LNR of CE-T1WI and height (r=-0.322, p=0.094), width (r=-0.233, p=0.232) and area (r=-0.309, p=0.109) of MRS tCho. There was no statistically significant correlation between LNR of DIR and height (r=0.067, p=0.735), width (r=-0.287, p=0.139) and area (r=0.012, p=0.953) of MRS tCho, either. The Pearson's correlation coefficient was 0.186 between LNRs of CE-T1WI and DIR (p=0.344).

Conclusion

There was no statistically significant correlation between LNR of DIR and relative amount of tCho resonance of MRS.

Keywords: Breast MRI, Double inversion recovery, MR spectroscopy, Breast cancer, Correlation

Figures and Tables

Fig. 1
Representative double inversion recovery (DIR) image and MRS spectrum on a patient with invasive ductal carcinoma in 47-year-old woman.
a. About 3.0 cm sized rim enhancing oval mass was noted at upper central portion of the right breast in sagittal scan of contrast-enhanced T1-weighted imaging (CE-T1WI). b. In sagittal DIR image, the mass shows the bright high signal intensity compared with that of normal parenchyma which results the lesion more conspicuous. c. Single-voxel MR spectroscopy reveals prominent tCho resonance peak at 3.2ppm. The height, width and area of the tCho were 1.068, 0.1 and 0.120, respectively.
jksmrm-18-34-g001
Fig. 2
Representative double inversion recovery (DIR) image and MRS spectrum on a patient with mucinous carcinoma in 66-year-old woman.
a. About 2.5 cm sized heterogenous enhancing mass was shown at the left central breast in sagittal contrast-enhanced T1-weighted imaging (CE-T1WI). b. Axial scan of DIR image represents rather iso- to low signal intensity mass at the left central breast. c. At 3.2ppm resonance, a striking tCho peak was visualized with the height, width and area as 0.526, 0.11 and c 0.065, respectively.
jksmrm-18-34-g002
Table 1
Baseline Characteristics
jksmrm-18-34-i001

Note.-N/A, Not Applicable

Table 2
Result of Height, Width, Area of the Total Choline-containing Compound (tCho) Resonance Peak and the Lesion-to-normal Ratio (LNR) of Contrast-enhanced T1-weighted Imaging (CE-T1WI) and Double Inversion Recovery (DIR)
jksmrm-18-34-i002

Note.-LNR: lesion-to-normal ratio

SD: standard deviation

N: total number

CE-T1WI: Contrast Enhanced- T1Weighted Image

DIR: Double Inversion Recovery

IDC: Invasive Ductal Carcinoma

Table 3
Pearson's Correlation of Height, Width, Area of the Total Choline-containing Compound (tCho) Resonance Peak and the Lesion-to-normal ratio (LNR) of Contrast-enhanced T1-weighted Imaging (CE-T1WI) and Double Inversion Recovery (DIR)
jksmrm-18-34-i003

Note.-r: Pearson's correlation coefficient

p: level of significance

DIR: Double Inversion Recovery

CE-T1WI: Contrast Enhanced- T1Weighted Image

IDC: Invasive Ductal Carcinoma

Notes

This work was supported by a grant from the Kyung Hee University in 2012(KHU-20120762).

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