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Kim, Kim, Shin, Kim, Na, Park, and Choi: A Study of Changes of Inversion Time Effect on Brain Volume of Normal Volunteers
Original Article

Journal of the Korean Society of Magnetic Resonance in Medicine 2013; 17(4): 286-293.

Published online: 27 December 2013

DOI: https://doi.org/10.13104/jksmrm.2013.17.4.286

A Study of Changes of Inversion Time Effect on Brain Volume of Normal Volunteers

Ju Ho Kim1, 2, Seong-Hu Kim2, Hwa Seon Shin3, Ji-Eun Kim3, Jae Boem Na3, Kisoo Park4, 5, Dae Seob Choi3, 5

1Department of Neurobiology, Gyeongsang National University Graduate School, Korea.

2Department of Radiology, Gyeongsang National University Hospital, Korea.

3Department of Radiology, Gyeongsang National University School of Medicine, Korea.

4Department of Preventive Medicine, Gyeongsang National University School of Medicine, Korea.

5Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, Korea.

Corresponding author: Dae Seob Choi, M.D., Ph.D. Departments of Radiology, Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, 90 Chiram-dong, Jinju-si, Gyeongsangnam-do 660-702, Korea. Tel. 82-55-750-8211, Fax. 82-55-755-1568, choids@gnu.ac.kr

Received 16 May 2013       Revised 26 September 2013       Accepted 8 October 2013

Copyright © 2013 Journal of the Korean Society of Magnetic Resonance in Medicine

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

The objective of this study was to analyze the brain volume according to the brain image of healthy adults in the 20s taken with different inversion time (TI).

Materials and Methods

Brain images of healthy adults in the 20 s were acquired using magnetization prepared rapid acquisition gradient echo (MPRAGE) pulse sequence with 1.5 mm thickness of pieces and four inversion times (1100 ms, 1000 ms, 900 ms, 800 ms). The acquired brain images were analyzed to measure the volume of white matter (WM), gray matter (GM), intracranial volume (ICV). The statistical difference according to brain volume and gender was analyzed for each TI.

Results

The brain volume calculated using Freesurfer was WM=486.52±48.64 cm3 and GM=646.86±57.12 cm3 in mean when adjusted by mean ICV=1278.94±154.92 cm3. Men's brain volume(WM, GM, ICV) was larger than women's brain volume. In the intrarater reliability test, all of the intraclass correlation coefficients were high (0.992 for WM, 0.988 for GM, and 0.997 for ICV). In the repeated measures analysis of variance, GM and ICV did not show a significant difference at each TI (GM p=0.143, ICV p=0.052), but WM showed a significant (p=0.001). In the linear structure relation analysis, all of the Pearson correlation coefficients were high.

Conclusion

WM, GM, and ICV indicated high reliability and solid linear structure relations, but WM showed significant differences at each TI. The brain volume of healthy adults in the 20s could be used in comparison with that of patients for reference purposes and to predict the structural change of brain. It would be needed to conduct additional studies to examine the contract, SNR, and lesion detection ability according to variable TI.

Keywords: Freesurfer, Volumetry, Magnetic resonance Imaging (MRI), Inversion time

Figures and Tables

Fig. 1
The results of images from the 3D MRI using automatic segmentation software. Original image (a), brain mask image (b), that removed skull from the original image (c), white matter (d). (Numerical values are inversion time in milliseconds)
jksmrm-17-286-g001
Fig. 2
The results of each subject is represented as mean volumes on the image acquisition conditions (white matter, gray matter, intracranial volume).
jksmrm-17-286-g002
Fig. 3
Scatter plot matrix for correlation analysis of inversion times of brain volumes (white matter, gray matter, intracranial volume).
jksmrm-17-286-g003
Table 1
The Mean Volumes(Adjusted to Intracranial Volume) for the White Matter, Gray Matter and Intracranial Volume (means±SD) Depending on the Inversion Time
jksmrm-17-286-i001
Table 2
The Statistical Difference According to Brain Volume and Gender Using Repeated Measures Analysis of Variance
jksmrm-17-286-i002
Table 3
Pearson Correlation Coefficients Between Inversion Times of Volumes (White Matter, Gray Matter, Intracranial Volume) among 20 Healthy Adults
jksmrm-17-286-i003

**. Correlation is significant at the 0.01 level

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