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Yoon, Park, Lee, Song, Lee, and Goo: Feasibility of In vivo Proton Magnetic Resonance Spectroscopy for Lung Cancer
Original Article
Journal of the Korean Society of Magnetic Resonance in Medicine

Journal of the Korean Society of Magnetic Resonance in Medicine 2012; 16(1): 40-46.

Published online: 30 April 2012

DOI: https://doi.org/10.0000/jksmrm.2012.16.1.40

Feasibility of In vivo Proton Magnetic Resonance Spectroscopy for Lung Cancer

Soon Ho Yoon1, Chang Min Park1, 2, Chang Hyun Lee1, 3, In-Chan Song1, Hyun Ju Lee1, Jin Mo Goo1, 2

1Department of Radiology, Seoul National University College of Medicine, Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Korea.

2Cancer Research Institute, Seoul National University, Seoul, Korea.

3Seoul National University Hospital, Healthcare Gangnam Center, Seoul, Korea.

Corresponding author: Jin Mo Goo, M.D., Department of Radiology, Seoul National University Hospital, 101 Daehangno, Jongno-gu, Seoul 110-744, Korea. Tel. 82-2-2072-2624, Fax. 82-2-743-7418, jmgoo@plaza.snu.ac.kr

Received 20 February 2012       Revised 25 April 2012       Accepted 25 April 2012

Copyright © 2012 Korean Society of Magnetic Resonance in Medicine

Abstract

Purpose

To investigate the feasibility of in vivo proton magnetic resonance spectroscopy (MRS) for evaluation of lung cancer.

Materials and Methods

This prospective study was approved by the institutional review board of our hospital and informed consent was obtained in all patients. Ten patients (7 men, 3 women; mean age, 64.4) with pathologicallyproven lung cancer (mean, 56.8 mm; range, 44-77 mm) were enrolled to 1.5 T MRS using a single-voxel respiration-triggered point-resolved spectroscopic sequence. Technical success rate and the reason of technical failure, if any, were investigated.

Results

Out of 10 lung cancers, analyzable MRS spectra were obtained in 8 tumors (technical success rate, 80%). Two MRS datasets were not able to be analyzed due to serious baseline distortion. Choline and lipid signals were detected as major metabolites in analyzable MRS spectra.

Conclusion

In vivo proton MRS method using a single-voxel respiration-triggered point-resolved spectroscopic sequence is feasible in obtaining the MR spectra of lung cancer because these spectra were analyzable and high success rate was shown in our study although there was the limitation of small patient group.

Keywords: Magnetic resonance, Spectroscopy, Lung cancer

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