Acute Hemolysis and Renal Failure caused by Hepatitis A Infection with Underlying Glucose-6-Phosphate Dehydrogenase Deficiency

Dong Wook Jekarl; Eun-Jee Oh; Yeon-Joon Park; KyungJa Han; Sung Won Lee; Chong-Won Park

doi:10.3343/kjlm.2007.27.3.188

Journal List > Korean J Lab Med > v.27(3) > 1011390

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Jekarl, Oh, Park, Han, Lee, and Park: Acute Hemolysis and Renal Failure caused by Hepatitis A Infection with Underlying Glucose-6-Phosphate Dehydrogenase Deficiency

Original Article

Korean J Leg Med 2007;27(3):188-191.

Published online: 10 February 2007

DOI: https://doi.org/10.3343/kjlm.2007.27.3.188

Acute Hemolysis and Renal Failure caused by Hepatitis A Infection with Underlying Glucose-6-Phosphate Dehydrogenase Deficiency

Dong Wook Jekarl, M.D.¹, Eun-Jee Oh, M.D.¹, Yeon-Joon Park, M.D.¹, KyungJa Han, M.D.¹, Sung Won Lee, M.D.², Chong-Won Park, M.D.²

¹Department of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea

²Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea

Received 31 October 2006 Revised 2 April 2007 Accepted 18 May 2007

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Although glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzyme disorder worldwide, it has rarely been reported among Korean. The patient was previously healthy 39 yr old male who showed severe hemolytic anemia and acute renal failure accompanied by hyper-bilirubinemia after hepatitis A infection. The additional studies for differential diagnosis of hemolytic anemia showed a moderate deficiency of G6PD enzyme. Because hepatitis A infection in patient with G6PD deficiency present much more severe clinical symptoms, G6PD enzyme should be examined in patients with triggering factors of hemolysis such as hepatitis A infection.

Keywords: Glucose-6-phosphate dehydrogenase deficiency, Hepatitis A virus, Hemolytic anemia, Acute renal failure

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Fig. 1.

Leukoerythroblastic reaction and thrombocytosis in peripheral blood smear (A) (Wright Giemsa stain, ×400). Normal cellularity with erythroid hyperplasia in bone marrow aspirate smear (B) (×1,000).

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