A Case of Acute Lymphoblastic Leukemia with ider(9)(q10)t(9;22)(q34;q11.2)

Jungwon Huh; Whasoon Chung

doi:10.3343/kjlm.2006.26.3.223

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Huh and Chung: A Case of Acute Lymphoblastic Leukemia with ider(9)(q10)t(9;22)(q34;q11.2)

Original Article

Korean J Leg Med 2006;26(3):223-226.

Published online: 10 February 2006

DOI: https://doi.org/10.3343/kjlm.2006.26.3.223

A Case of Acute Lymphoblastic Leukemia with ider(9)(q10)t(9;22)(q34;q11.2)

Jungwon Huh, M.D., Whasoon Chung, M.D.

Department of Laboratory Medicine, Ewha Womans University, College of Medicine, Seoul, Korea

Received 11 January 2006 Revised 24 April 2006 Accepted 3 May 2006

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

ider(9)(q10)t(9;22)(q34;q11.2) is an isochromosome for the long arm of a derivative chromosome 9 generated by a t(9;22), resulting from the deletion of the short arm of chromosome 9. It is known to be rarely observed in acute lymphoblastic leukemia (ALL) or lymphoblastic crisis transformed from chronic myelogenous leukemia. We herein describe a 26-year-old female patient with precursor B-cell ALL, cytogenetically characterized by ider(9)(q10)t(9;22). Fluorescence in situ hybridization analysis showed two ABL-BCR fusion signals on the derivative chromosome 9 and one BCR-ABL fusion signal on the derivative chromosome 22. Although a t(9;22) and a deletion of the short arm of chromosome 9 are known to be associated with a poor prognostic factor in acute lymphoblastic leukemia, a larger study is needed to determine the prognosis of ider(9)(q10)t(9;22) cases.

Keywords: Acute lymphoblastic leukemia, ider(9)(q10)t(9;22), Deletion of the short arm of chromosome 9, t(9;22), Fluorescence in situ hybridization, BCR-ABL

References

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Fig. 1.

G-banded karyotype, demonstrating ider(9)(q10)t(9;22) (q34;q11.2) and der(22)t(9;22) (arrows).

Fig. 2.

FISH with BCR/ABL probe. One red and one green signals are present on the normal chromosome 9 and 22, respectively. One yellow fusion signal is present on der(22)t(9;22). Two yellow fusion signals are present on ider(9)(q10)t(9;22).

Table 1.

Summary of cases with ider(9)(q10)t(9;22)(q34;q11.2)

Case No.	Sex/Age	Diagnosis	Karyotype	Ref
1	M/30	ALL	46,XY,add(1)(p36),ider(9)(q10)t(9;22)(q34;q11.2),add(12)(p13),add(16)(p13),der(22)t(9;22)[8]/46,XY[2]	[2]
2	M/57	CML, lymphoid BP	46,XY,t(9;22)(q34;q11.2)[6]/46,XY, ider(9)(q10)t(9;22),der(22)t(9;22) [9]/47,XY,+8,ider(9)(q10)t(9;22),der(22) t(9;22)[5]	[2]
3	F/26	CML, lymphoid BP	46,XX,t(9;22)(q34;q11.2)[9]/45,XX,-7, ider(9)(q10)t(9;22),der(22)t(9;22)[3]/46,XX[8]	[3]
4	M/34	CML, BP	46,XY,t(9;22)(q34;q11.2)[2]/46,XY,ider(9) (q10)t(9;22),der(22)t(9;22)[5]	[4]
5	F/63	ALL	46,XX,idic(9)(p13)t(9;22)(q34;q11.2), der(22)t(9;22)/46,XX	[5]
6	M/16	ALL	46,XY,ider(9)(q10)t(9;22),ider(22)(q10) t(9;22)	[6]
7	M/42	CML, lymphoid BP	46,XY,t(9;22)(q34;q11.2)[12]/46,XY, ider(9)(q10)t(9;22),der(22)t(9;22)[10]/45, XY,-9,der(22)t(9;22)[3]	[7]
8	M/53	ALL	46,XY,t(9;22)(q34;q11.2)[4]/45,XY,-7,i(8)(q10),ider(9)(q10)t(9;22),der(22)t(9;22)[32]/46,XY[5]	[8]
9	M/31	ALL	46,XY,ider(9)(q10)t(9;22),der(22)t(9;22) [23]/46,XY[4]	[8]
10	F/26	ALL	46,XX,ider(9)(q10)t(9;22)(q34;q11.2), der(22)t(9;22)[10]/46,XX[10]	This study

Abbreviations: ALL, acute lymphoblastic leukemia; CML, chronic myelogenous leukemia; BP, blastic phase; Ref, reference number.

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