A Granulocytic Sarcoma of Right Uterine Adnexa Region as an Extramedullary Relapse in a Patient with Chronic Myeloid Leukemia

Yong Gon Cho; Jae Hyun Lee; Na Rhee Lee; Dal Sik Kim; Hye Soo Lee; Sam Im Choi

doi:10.3343/kjlm.2006.26.3.143

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Cho, Lee, Lee, Kim, Lee, and Choi: A Granulocytic Sarcoma of Right Uterine Adnexa Region as an Extramedullary Relapse in a Patient with Chronic Myeloid Leukemia

Original Article

Korean J Leg Med 2006;26(3):143-145.

Published online: 10 February 2006

DOI: https://doi.org/10.3343/kjlm.2006.26.3.143

A Granulocytic Sarcoma of Right Uterine Adnexa Region as an Extramedullary Relapse in a Patient with Chronic Myeloid Leukemia

Yong Gon Cho, M.D.^1,³, Jae Hyun Lee, M.D.¹, Na Rhee Lee, M.D.², Dal Sik Kim, M.D.^1,³, Hye Soo Lee, M.D.^1,³, Sam Im Choi, M.D.^1,³

¹Department of Laboratory Medicine, Chonbuk National University Medical School, Chonbuk National University, Jeonju, Korea

²Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Korea

³Department of Research Institute of Clinical Medicine, Chonbuk National University, Jeonju, Korea

Received 25 October 2005 Revised 4 May 2006 Accepted 28 May 2006

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Granulocytic sarcoma of the uterine adnexa is a rare event. A 50-year-old woman, who had previously been diagnosed as chronic myeloid leukemia (CML), but had a complete hematologic response, presented with lower abdominal pain and a large pelvic mass involving the right uterine adnexa region and extending to the right posterior wall of the bladder and right distal ureter. A biopsy of the uterine adnexa revealed granulocytic sarcoma, and a subsequent bone marrow biopsy confirmed the diagnosis of CML in the blastic phase.

Keywords: Granulocytic sarcoma, Adnexa uteri, Chronic myelogenous leukemia

References

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Fig. 1.

MRI of the pelvis with enhancement shows a mass of the right uterine adnexa region with a size of 6.5×6.0 cm infiltrating the wall of the bladder and uterus.

Fig. 2.

Biopsy pictures of the uterine mass. (A) H&E stain, ×400, show the infiltrating leukemic blasts. The granulocytic cells are positive with immunohistochemical stain for anti-CD68 (B) and lysozyme (C), focal positive for c-kit (CD117) (D) (×400).

Fig. 3.

Blood pictures in (A) peripheral blood smear (×1,000) and (B) bone marrow biopsy (×400). All findings are consistent with chroninc myeloid leukemia in blastic phase.

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