Journal List > J Korean Surg Soc > v.80(2) > 1011243

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Kim, Kim, Park, Kim, Oh, and Choi: Malignant Fibrous Histiocytoma Originating in the Short-term after Excision
Case Report
Journal of the Korean Surgical Society

Journal of the Korean Surgical Society 2011; 80(2): 147-150.

Published online: 7 February 2011

DOI: https://doi.org/10.4174/jkss.2011.80.2.147

Malignant Fibrous Histiocytoma Originating in the Short-term after Excision

Ki Hoon Kim, M.D., Jin Su Kim, M.D., Sung Jin Park, M.D., Woon-Won Kim, M.D., Sang Hoon Oh, M.D., Su Im Choi, M.D.1

Department of Surgery, Haeundae Paik Hospital, University of Inje College of Medicine, Busan, Korea.

1Department of Pathology, Haeundae Paik Hospital, University of Inje College of Medicine, Busan, Korea.

Corresponding author (medhun@hanmail.net)

Received 22 October 2010       Accepted 21 December 2010

Copyright © 2011 The Korean Surgical Society

Abstract

MFH is rare with just a few thousand cases diagnosed each year. We report a case of right flank malignant fibrous histiocytoma (MFH) in the short-term after tumor excision. A 47-year-old woman visited hospital after being diagnosed with MFH. Resection margin was positive, so we planned for wide excision. While awaiting surgery, 1.5 cm sized new mass occurred adjacent to the incision site. The patient underwent wide excision. Postoperative pathologic findings observed a 1.0 cm diameter mass with infiltrative borders in the subcutaneous fat. It was composed of spindle or epithelial cell showing severe polymorphism. Many mitotic cells were observed including atypia. In immunohistochemical study, tumor cells were negative for smooth muscle actin, desmin, myoglobin, S100, cytokeratin, and positive for CD68, and thus diagnosed as pleomorphic MFH. With the purpose of improving local tumor control, radiation therapy was performed after wide excision.

Keywords: Malignant fibrous histiocytoma (MFH), Resection margin, Wide excision

Figures and Tables

Fig. 1
PET CT findings. There is a mild FDG-avid lesion in right flank (skin and subcutaneous area).
jkss-80-147-g001
Fig. 2
(A) Microscopic findings of the right flank mass. The tumor has un encapsulated ill-defined margin infiltrating surrounding subcutaneous adipose tissue (H&E, ×12.5). (B) Microscopic findings of the right flank mass. The spindle tumor cells grow in fascicular pattern (H&E, ×100). (C) Microscopic findings of the right flank mass. The tumor cells have markedly pleomorphic nuclei with frequent mitoses (H&E, ×400).
jkss-80-147-g002

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