Journal List > J Korean Surg Soc > v.79(6) > 1011212

Seo, Lee, Lee, Chang, Lee, Lee, and Hong: Solitary Fibrous Tumor That Developed in the Thigh

Abstract

A solitary fibrous tumor (STF) is a relatively unusual neoplasm first described as a distinctive tumor arising from pleura. Some reports have shown that STF also affect extrathoracic regions. A 70-year-old woman was referred to our hospital for surgical treatment of an incidentally discovered thigh mass. We performed complete removal of the tumor. It was a soft tissue tumor with muscle indentation but without invasion to the surrounding muscles. The resected specimen was 7.0×6.3×5.2 cm. Histologically, the tumor was composed of a haphazard proliferation of spindle cells and epitheloid cells with hypercellularity and high mitotic activity. Immunohistochemistry showed positive immunoreactivity for CD34, CD99, bcl-2 protein, CD117, vimentin, smooth muscle actin and epithelial membrane antigen. We report, herein, on a rare case of malignant SFT in the thigh region along with a review of the literature.

Figures and Tables

Fig. 1
A subcutaneous tumor in the thigh. The tumor is 10×7 cm in size, solid and skin colored.
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Fig. 2
MRI images of the mass in the thigh. A MRI shows 6.6×5.5×4.7 cm sized well-defined lobulated mass in the subcutaneous fat layer of left thigh. (A) Homogeneous low SI on T1WI, (B) heterogeneous high SI on T2WI.
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Fig. 3
Gross findings of the thigh mass. (A) The mass shows 7.0×6.3×5.2 cm sized, oval shaped, soft and friable tumor and cut surfaces are homogenously cream yellow to pinkish purple with a fish-flesh appearance. (B) The cut surfaces are multifocally spotty petechially hemorrhagic and focal minimally necrotic.
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Fig. 4
Malignant solitary fibrous tumor. (A) The tumor shows hemangiopericytomatous pattern of mainly spindle & partly epitheloid tumor cells (H&E stain, ×200). (B) Mainly spindle & partly epitheloid tumor cells have relatively high mitotic activity and focal mild nuclear atypia & pleomorphism (H&E stain, ×400).
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Fig. 5
Immunohistochemical stain. (A) Tumor cells show strong positive staining for CD34, ×400. (B) Tumor cells show strong positive staining for BCL2, ×400.
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