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Journal List > J Korean Surg Soc > v.79(1) > 1011185

Baik, Yang, and Shin: Clinicopathological Analysis of Recurrence in Stage 1 Gastric Cancer

Abstract

Purpose

Recently, diagnosis of stage 1 gastric cancer has increased in number and prognosis is excellent when proper treatment is done. However, some patients have recurrence and their prognosis is poor. Thus, we investigated the risk factors of recurrence in stage 1 gastric cancer patients.

Methods

From January 2004 to December 2008, a total of 1,241 number patients were operated on for stage 1 gastric cancer at the Department of General Surgery, Kosin University Gospel Hospital. We reviewed the characteristics of all patients retrospectively and compared them to recurred group (n=24) and non-recurred group (n=1,114). We analyzed the risk factors associated with recurrence.

Results

Twenty-four patients with stage 1 gastric cancer were recurred after radical gastrectomy. Recurrence rate was 2.05%. The most common pattern of recurrence was hematogenous (41.7%), and lymphatic (20.8%), peritoneal seeding (16.7%), combined form (12.5%), and locoregional (8.3%). Five-year survival rate was 50.08% of recurrence group. Of clinicopathological factors, depth of invasion, lymph node metastasis, lymphatic involvement and tumor marker were statistically significant between recurred and other group.

Conclusion

In this study, tumor marker, tumor depth, node status, lymphatic channel involvement were possible risk factors of recurrence for stage 1 gastric cancer. More intensive follow up and care is needed for those with such risk factors.

Figures and Tables

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Fig. 1
Survival curves of recur and non-recur group.

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Fig. 2
Survival curves by recurrence pattern.

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Table 1
Clinicopathological characteristics of patients
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*CEA = carcinoembryonic antigen; RSG = radical subtotal gastrectomy; RTG = radical total gastrectomy; §PRM = proximal resection margin; DRM = distal resection margin.

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Table 2
Duration and site of recurrence
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Table 3
Pattern of recurrence
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Table 4
Results of multi-variant analysis of significant factors
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*95% CI = 95% confidence interval; CEA = carcinoembryonic antigen.

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