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Si, Lee, Kim, Kim, Kim, Lee, Cho, Kim, Oh, and Lee: Clinicopathological Characteristics of Ovarian Metastasis from Colorectal Cancer
Original Article
Journal of the Korean Surgical Society

Journal of the Korean Surgical Society 2010; 79(4): 287-293.

Published online: 31 October 2010

DOI: https://doi.org/10.4174/jkss.2010.79.4.287

Clinicopathological Characteristics of Ovarian Metastasis from Colorectal Cancer

Youn Si, M.D., Jae-Im Lee, M.D., Soo-Hong Kim, M.D., Ji-Hoon Kim, M.D., Hyung Jin Kim, M.D., Yoon Suk Lee, M.D., Hyun Min Cho, M.D., Jun Gi Kim, M.D., Seung Tack Oh, M.D., In Kyu Lee, M.D.

Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Corresponding author (cmcgslee@catholic.ac.kr)

Received 28 April 2010       Accepted 7 July 2010

Copyright © 2010 The Korean Surgical Society

Abstract

Purpose

Treatment of ovarian metastasis from colorectal cancer has been controversial. We investigated the clinicopathologic features and treatment outcomes of patients with ovarian metastasis from colorectal carcinoma.

Methods

From January 1996 to May 2009, 567 women were treated for colorectal cancer. Of those, 23 patients were diagnosed as having ovarian metastasis. We reviewed 19 pathologically proven cases, retrospectively.

Results

The incidence of ovarian metastasis was 4.0%. The number of cases involving synchronous ovarian metastases was 9 (47.4%), and 10 cases (52.6%) involved metachronous ovarian metastases. Thirteen patients had metastases located in the pelvis and 6 also had peritoneal dissemination in addition to the ovarian metastasis. Twenty (63.1%) were treated with grossly complete resection. After a median follow-up duration of 45 months (range of 6~96 months), the median survival after the diagnosis of ovarian metastasis was 40 months. The median overall survival was significantly longer in the grossly complete resection group (48.5 vs. 16 months; P=0.001). For median survival after the diagnosis of ovarian-metastasis, patients with grossly complete resection showed a significantly more favorable survival rate than the group with remnant tumors (46.5 vs 9 months; P=0.009). The survival of patients with metastases located in the pelvis was better than the group with peritoneal dissemination.

Conclusion

Grossly complete resection would be of help to improve the prognosis in selective patients with metastasis from colorectal cancer, especially when metastasis is located in the pelvis.

Keywords: Colorectal cancer, Ovarian metastasis

Figures and Tables

Fig. 1
Kaplan-Meier survival curve of the ovary-specific survival time after ovarian metastasis.
jkss-79-287-g001
Fig. 2
Kaplan-Meier survival curve comparing the ovary-specific survival time (A) and overall survival time (B) according to the complete resection.
jkss-79-287-g002
Fig. 3
Kaplan-Meier survival curve comparing the ovary-specific survival time (A) and overall survival time (B) according to the extent of disease.
jkss-79-287-g003
Table 1
Clinical characteristics of primary tumors in 19 women
jkss-79-287-i001
Table 2
Pathologic feature of primary tumors in 19 women
jkss-79-287-i002

*FOLFOX = leucovorin+fluorouracil+oxaliplatin; †FOLFIRI = leucovorin+fluorouracil+irinotecan.

Table 3
Clinicopathologic features of ovary metastasis according to the grossly complete resection
jkss-79-287-i003
Table 4
Comparison of primary tumors according to the timing of metastasis
jkss-79-287-i004

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