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Kwak, Choi, Woo, Kim, Um, and Kim: Antimicrobial Prophylaxis Using a 2nd Generation Cephalosporin after Laparoscopic Colorectal Resection: A Randomized Trial of 1-day vs. 3-day
Original Article
Journal of the Korean Surgical Society

Journal of the Korean Surgical Society 2010; 78(6): 385-389.

Published online: 7 June 2010

DOI: https://doi.org/10.4174/jkss.2010.78.6.385

Antimicrobial Prophylaxis Using a 2nd Generation Cephalosporin after Laparoscopic Colorectal Resection: A Randomized Trial of 1-day vs. 3-day

Han Deok Kwak, M.D., Dong Jin Choi, M.D., Si Uk Woo, M.D., Jin Kim, M.D., Jun Won Um, M.D.1, Seon Hahn Kim, M.D.

Department of Surgery, Korea University Anam Hospital, Seoul, Korea.

1Department of Surgery, Korea University Ansan Hospital, Ansan, Korea.

Corresponding author (drkimsh@korea.ac.kr)

Received 11 December 2009       Accepted 8 March 2010

Copyright © 2010 The Korean Surgical Society

Abstract

Purpose

We performed this study to compare 1-day group using a 2nd generation cephalsporin with 3-day group for evaluating hospital acquired infection.

Methods

The patients underwent laparoscopic colorectal surgery at Korea University Medical Center Anam Hospital, from August, 2007 to June, 2008. They were randomly allocated to 2 groups: 1-day or 3-day group. A 2nd generation cephalosporin was administered within 1 hour before surgery with 12-hour intervals. In cases of suspected infection, further studies were done to identify infection.

Results

The study included 154 patients (1-day group - 78, vs. 3-day group - 76). No differences were noted between the 2 groups in age, body mass index, smoking, diabetes mellitus, corticosteroid-use were noted. Gender (P=0.011) and mean operative time (P=0.047) between the 2 groups were different. The preventive rates of infection were 87.18% in the 1-day group compared with 82.89% in the 3-day group (P=0.456).

Conclusion

Our prospective randomized control study concluded that there were no differences between the 1-day and 3-day group in hospital acquired infection. We could come to the conclusion that 1-day antimicrobial agent in laparoscopic colorectal surgery would be adequate in preventing infection.

Keywords: Antimicrobial prophylaxis, Monotherapy, Laparoscopic colorectal surgery, Surgical site infection, Hospital acquired infection

Figures and Tables

Table 1
Clinical characteristics
jkss-78-385-i001
Table 2
Indications for surgery and selected operative details
jkss-78-385-i002
Table 3
Postoperative variables
jkss-78-385-i003
Table 4
Hospital acquired infection and results of 1-day vs 3-day group
jkss-78-385-i004

*FUO = fever of unknown origin; †UTI = urinary tract infection.

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