Abstract
Solitary fibrous tumor of the liver is a rare neoplasm. Thirty-nine cases have been described in the English literature. Its immunohistochemical positivity for CD34 and vimentin is believed to be unique. It is known to be usually benign and only one case of metastasis is reported. We report an additional case. A 71-year-old woman presented with fatigue and weight loss. CT scan showed a solid mass occupying the left lobe of the liver. Left lobectomy was performed. Pathological examination showed spindle cell and fibroblast-like cells within the collagenous stroma. On immunohistochemical staining, these spindle tumor cells showed diffuse CD34 and vimentin positive reactivity. The post-operative course was uneventful. Solitary fibrous tumors of the liver, although rare, need to be considered in the differential diagnosis of mesenchymal lesions of the liver.
References
1. Briselli M, Mark EJ, Dickersin GR. Solitary fibrous tumors of the pleura: eight new cases and review of 360 cases in the literature. Cancer. 1981. 47:2678–2689.
2. Cameselle-Teijeiro J, Varela-Duran J, Fonseca E, Villanueva JP, Sobrinho-Simoes M. Solitary fibrous tumor of the thyroid. Am J Clin Pathol. 1994. 101:535–538.
3. Dorfman DM, To K, Dickersin GR, Rosenberg AE, Pilch BZ. Solitary fibrous tumor of the orbit. Am J Surg Pathol. 1994. 18:281–287.
4. Yilmaz S, Kirimlioglu V, Ertas E, Hilmioglu F, Yildirim B, Katz D, et al. Giant solitary fibrous tumor of the liver with metastasis to the skeletal system successfully treated with trisegmentectomy. Dig Dis Sci. 2000. 45:168–174.
5. Edmondson HA. Tumors of the Liver and Intrahepatic Bile Ducts. Atlas of Tumor Pathology Fascicle 25. 1958. Washington: Armed Forces Institute of Pathology;113–137.
6. Perini MV, Herman P, D'Albuquerque LA, Saad WA. Solitary fibrous tumor of the liver: report of a rare case and review of the literature. Int J Surg. 2008. 6:396–399.
7. Kwak SY, Gwak GY, Yun WK, Kim HJ, Do IG, Joh JW, et al. A case of solitary fibrous tumor of the liver. Korean J Hepatol. 2007. 13:560–564.
8. Neeff H, Obermaier R, Technau-Ihling K, Werner M, Kurtz C, Imdahl A, et al. Solitary fibrous tumour of the liver: case report and review of the literature. Langenbecks Arch Surg. 2004. 389:293–298.
9. Fuksbrumer MS, Klimstra D, Panicek DM. Solitary fibrous tumor of the liver: imaging findings. AJR Am J Roentgenol. 2000. 175:1683–1687.
10. Vallat-Decouvelaere AV, Dry SM, Fletcher CD. Atypical and malignant solitary fibrous tumors in extrathoracic locations: evidence of their comparability to intra-thoracic tumors. Am J Surg Pathol. 1998. 22:1501–1511.