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Kang, Kim, Yoon, and Lee: Prognostic Factors and Clinicopathologic Features after Resection of Small Hepatocellular Carcinoma (≤2 cm)
Original Article
Journal of the Korean Surgical Society

Journal of the Korean Surgical Society 2009; 76(2): 94-99.

Published online: 28 February 2009

DOI: https://doi.org/10.4174/jkss.2009.76.2.94

Prognostic Factors and Clinicopathologic Features after Resection of Small Hepatocellular Carcinoma (≤2 cm)

Sang-Yoon Kang, M.D, Hong-Jin Kim, M.D, Sung-Su Yoon, M.D, Dong-Shik Lee, M.D

Department of Surgery, College of Medicine, Yeungnam University, Daegu, Korea.

dslee@med.yu.ac.kr

Received 21 July 2008       Accepted 15 October 2008

Copyright © 2009 The Korean Surgical Society

Abstract

Purpose

Hepatectomy has been regarded as the first treatment of choice for small hepatocellular carcinoma. However, hepatectomy for treatment of small hepatocellular carcinoma remains a critical issue. This study evaluates the role of treatment regarding the survival rate and clinicopathological features after resection of small hepatocellular carcinoma (≤2 cm)

Methods

This retrospective study was based on the medical records of 48 small hepatocellular carcinoma (≤2 cm) patients who received surgical hepatectomy from 1990 to 2005. Patients who revealed on postoperative pathologic reports were enrolled. The survival rate was analyzed according to clinicopathologic and therapeutic factors and we analyzed the pathologic features of the recurrence group.

Results

The presence of liver cirrhosis, ICGR15 (Indocyanine green retension-15) was statistically significant in the univariate analysis. The vascular invasion rate and capsule formation rate was 90, 80% in the recurrence group.

Conclusion

In the small hepatocellular carcinoma (≤2 cm), the presence of liver cirrhosis, ICGR15 (Indocyanine green retension-15) should be checked to predict prognosis. The small hepatocellular carcinoma (≤2 cm) is similar to advanced hepatocellular carcinoma so hepatectomy may play an important role in the small hepatocellular carcinoma (≤2 cm).

Keywords: Small hepatocellular carcinoma (≤2 cm), Prognostic factors, Clinicopathologic factors

Figures and Tables

Fig. 1
Survival curves of 48 patients with small hepatocellular carcinoma.
jkss-76-94-g001
Fig. 2
Disease-free survival curves of 48 patients with small hepatocellular carcinoma.
jkss-76-94-g002
Fig. 3
Survival curves after resection with and without liver cirrhosis.
jkss-76-94-g003
Fig. 4
Survival curves after resection between above 10 of R15 and below 10 of R15.
jkss-76-94-g004
Fig. 5
Survival curves of 48 patients with small hepatocellular carcinoma after resection.
jkss-76-94-g005
Table 1
The characteristics of patient and tumor of small HCC (n=48)
jkss-76-94-i001
Table 2
The prognostic factors in patients with small hepatocelluar carcinoma (n=48)
jkss-76-94-i002

*5-YSR = 5 year survival rate; †AR = anatomical resection; ‡NAR = non anatomical resection.

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