Journal List > J Korean Surg Soc > v.76(5) > 1010959

Chun, Lee, Song, Kim, Kim, Ahn, Lee, Park, Choi, Kang, and Song: Comparative Analysis of Vascular Endothelial Growth Factor-A, C, D Expression in Colorectal Cancer with Liver Metastasis

Abstract

Purpose

We aimed to investigate the correlations between expressions of angiogenic cytokines VEGF-A, C, D of primary colorectal cancer and liver metastasis.

Methods

We examined paraffin-embedded primary colorectal cancer tissue from 45 patients who had liver resection due to colorectal liver metastasis (metastasis group) and 37 patients who had surgical resection due to colorectal cancer only (control group). In the control group, local recurrence and distant metastasis had not occurred. Immunohistochemical staining for VEGF-A, C and D was performed. We analysed the correlations between expression of VEGF-A, C and D in primary colorectal cancer tissues and clinicopathologic parameters.

Results

VEGF-A expressions of primary colorectal carcinoma were not different between the two groups. VEGF-C was more frequently expressed in the metastasis group (P=0.008) but VEGF-D was more expressed in the control group (P=0.003). Patients with VEGF-C negative and VEGF-D positive expression were predominant in the control group (P=0.020). Tumor location, T stage, lymph node metastasis and tumor differentiation were not related with the expressions of VEGF-A, C, D but only preoperative CEA was positively correlated with VEGF-A and C expression.

Conclusion

Expressions of VEGF-C in primary tumor were more frequent in metastatic colorectal cancer and expressions of VEGF-D were more frequent in nonmetastatic colorectal cancer. More large-scale prospective studies for VEGF-C and D expression in colorectal cancer are necessary.

Figures and Tables

Fig. 1
Overall survival of metastatic group according to expression of immunohistochemical staining of VEGF-A.
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Fig. 2
Overall survival of metastatic group according to expression of immunohistochemical staining of VEGF-C.
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Fig. 3
Overall survival of metastatic group according to expression of immunohistochemical staining of VEGF-D.
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Table 1
Patients characteristics
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*analyzed by student t-test.

Table 2
VEGF-A, C, D expression of primary colorectal cancer
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*analyzed by Chi-square test; analyzed by student t-test; SD = standard deviation.

Table 3
Correlation between clinicopathologic parameter and expression of VEGF-A
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*analyzed by Chi-square test; analyzed by student t-test; SD = Standard deviation.

Table 4
Correlation between clinicopathologic parameter and expression of VEGF-C
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*analyzed by Chi-square test; analyzed by student t-test; SD = Standard deviation.

Table 5
Correlation between clinicopathologic parameter and expression of VEGF-D
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*analyzed by Chi-square test; analyzed by student t-test; SD = Standard deviation.

Table 6
Correlation between liver metastasis of colorectal carcinoma and expression of VEGF-C and D
jkss-76-307-i006

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