Gastrointestinal Carcinoid Tumor: Clinical Review of 36 Cases

Bong Su Kang; Jong Woo Kim

doi:10.4174/jkss.2009.76.1.1

Journal List > J Korean Surg Soc > v.76(1) > 1010919

Go to TopGo to Top Go to BottomGo to Bottom

TOOLS

Kang and Kim: Gastrointestinal Carcinoid Tumor: Clinical Review of 36 Cases

Original Article

Journal of the Korean Surgical Society

Journal of the Korean Surgical Society 2009; 76(1): 1-6.

Published online: 31 January 2009

DOI: https://doi.org/10.4174/jkss.2009.76.1.1

Gastrointestinal Carcinoid Tumor: Clinical Review of 36 Cases

Bong Su Kang, M.D., Jong Woo Kim, M.D.

Department of Surgery, Bundang CHA Hospital, Pochon CHA University College of Medicine, Seongnam, Korea.

kjw@cha.ac.kr

Received 12 June 2008 Accepted 11 September 2008

Abstract

Purpose

The aim of this study is to analyze various clinical characteristics of gastrointestinal carcinoid tumors including their symptoms, diagnoses and treatment strategies.

Methods

Medical records of 36 cases of gastrointestinal carcinoid tumors diagnosed at Bundang CHA Hospital from March 2000 to February 2008 were reviewed and analyzed retrospectively.

Results

The mean age of patients at diagnosis was 50 years old. Frequent location of the tumors was as follows-rectum, duodenum, appendix, stomach, colon, and small bowel. The size of tumor varied and the mean size was measured 9.0 mm. Any specific symptoms did not arise nor were they detected among most of the patients at the time of diagnosis. Endoscopic resection of gastrointestinal carcinoid tumor was undergone in 27 cases, while 13 cases were resected with surgical procedures. Surgical procedures performed were appendectomy in 4 cases, transanal resection in 3 cases, low anterior resection in 3 cases, pancreaticoduodenectomy in 1 case, duodenotomy with mass excision in 1 case, ileotomy with mass excision in 1 case. One case of recurrence was reported during the follow-up period.

Conclusion

Gastrointestinal carcinoid tumors have various clinical presentations and the results are highly variable and also individualized according to the site of the primary tumor. It leads to a multiplicity of treatment options for the patients. The expertise of surgeons and endoscopic physicians should be combined for proper management strategies and effective results of carcinoid tumors of gastrointestinal tract treatment.

Keywords: Carcinoid, Gastrointestinal, Surgery

Figures and Tables

Table 1

Survey of clinical characteristics of patients

^*M = mucosa; ^†SM = submucosa; ^‡MP = muscle propria; ^§EMR = endoscopic mucosal resection; ^∥N = not examined.

Table 2

Clinical characteristics of patients

^*yr = year.

Table 3

Type of treatments and results

Table 4

Results of the endoscopic resection according to margin status

^*M = mucosa; ^†SM = submucosa; ^‡MP = muscle propria; ^§S = serosa; ^∥EMR = endoscopic mucosal resection.

Table 5

Results of the endoscopic resection according to the carcinoid

References

1. Lubarsch O. Ueber den primaren Krebs des ileum, nebst Bermerkingen uber das gleichzeitge Vorkomen von Krebs und Tuberkolose. Virchows Arch Pathol Anat. 1888. 111:280–317.

2. Oderndorfer S. Karzinoide Tumoren des Dunndarms. Frankf Z Pathol. 1907. 1:425–429.

3. Gosset A, Masson P. Tumerus endocrines de l'appendice. Presse Med. 1914. 22:237–240.

4. World Health Organization. Socia E, Kloppel G, Sobin LH, editors. Histological typing of endocrine tumors. International Histological Classification of Tumors. 2000. 2nd ed. Berlin: Springer-Verlag;1–160.

5. Chang YW. Gastrointestinal carcinoid tumors and factors predicting metastasis. Korean J Gastroenterol. 2007. 50:70–71.

6. Jeen YT, Chun HJ, Lee SJ, Kang CD, Lee HS, Song CW, et al. The clinical value of endoscopic ultrasonography in rectal carcinoid tumor. Korean J Gastrointest Endosc. 2000. 21:774–779.

7. Modlin I, Lye K, Kidd M. A 5 decade analysis of 13,715 carcinoid tumors. Cancer. 2003. 97:934–959.

8. Sun JM, Jung HC. Gastrointestinal carcinoid tumor. Korean J Gastroenterol. 2004. 44:59–65.

9. Jung KC, Kim HS, Song SY, Choe GY, Kim YI. Carcinoid tumors of the gastrointestinal tract: Analysis of 36 cases. Korean J Pathol. 1996. 30:396–407.

10. Chang JH, Kim SW, Chung WC, Kim YC, Jung CK, Paik CN, et al. Clinical review of gastrointestinal carcinoid tumor and analysis of the factors predicting metastasis. Korean J Gastroenterol. 2007. 50:19–25.

11. Park YB, Kim JI, Ha BW, Cheung DY, Kim TH, Kim CW, et al. Endoscopic treatment of gastrointestinal carcinoid tumors. Korean J Med. 2007. 73:274–282.

12. Song SK, Choi ST, Kim KK, Lee JN, Oh JH, Park YH, et al. Clinical review of appendiceal tumors. J Korean Surg Soc. 2007. 73:42–47.

13. Berge T, Linnell F. Carcinoid tumors: frequency in a defined population during a 12 year period. Acta Pathol Microbiol Scand. 1976. 84:322–330.

14. Feldman J, O'Dirisio T. Role of neuropeptide and serotonin in the diagnosis of carcinoid tumors. Am J Med. 1986. 81:41–48.

15. Janson E, Holmberg L, Stridsberg M, Eriksson B, Theodorsson E, Wilander E, et al. Carcinoid tumors: analysis of prognostic factors and survival in 301 patients from a referral center. Ann Oncol. 1997. 8:685–690.

16. Kulke MH. Clinical presentation and management of carcinoid tumors. Hematol Oncol Clin N Am. 2007. 21:433–455.

17. Rindi G, Bordi C, Rappel S. Gastric carcinoids and neuroendocrine carcinomas: pathogenesis, pathology, and behavior. World J Surg. 1996. 20:168–172.

18. Modlin IM, Kidd M, Latich I, Zikusoka MN, Shapiro MD. Current status of gastroinestinal carcinoids. Gastroenterology. 2005. 128:1717–1751.

19. Higaki S, Nishiaki M, Mitani N, Yanai H, Tada M, Okita K. Effectiveness of local endoscopic resection of rectal carcinoid tumors. Endoscopy. 1997. 29:171–175.

TOOLS

Similar articles