Journal List > J Korean Ophthalmol Soc > v.59(2) > 1010857

Park and Kim: A Case of Primary Mucinous Adenocarcinoma of the Lower Eyelid



To report a rare case of a recurrent painless mass of the right lower eyelid, which was histologically diagnosed as a mucinous adenocarcinoma.

Case summary

A 59-year-old male had a painless nodule on the right lower eyelid for 2 years. He had a history of five laser treatments done by a dermatologist prior to the initial presentation. Surgical shave biopsy was performed and a histopathological examination revealed a mucinous adenocarcinoma. We subsequently performed a pentagonal excision of the lower eyelid with assisted frozen biopsy until no tumor cells were seen at the margin. A postoperative whole-body positron emission tomography scan, chest computerized tomography, gastrointestinal endoscopy, and colonoscopy excluded systemic metastases. No recurrence has been observed for 18 months after the surgery.


Primary mucinous adenocarcinoma is a rare disorder of the eyelid. Because it has various morphologies, and the final diagnosis can only be made by histopathological examination. If there is a recurrent mass at the eyelid margin, adenocarcinoma should be considered as the differential diagnosis. A complete surgical excision is recommended to prevent local recurrence.

Figures and Tables

Figure 1

Clinical findings. (A) Preoperative appearance shows erythematous nodule with ulceration on the right lower eyelid. It is firm and non-tender nodule with smooth and shiny surface. The lesion had well-defined margin measuring about 0.7 × 0.6 cm. (B) After 3 weeks, ulceration progressed to the center of the nodule.

Figure 2

Histopathologic appearance of the surgical specimen. (A) The tumor cells are observed in the subepithelial stroma (Hematoxylin & eosin [H&E] stain, ×100). (B) The tumor shows sheets of atypical cells with abundant cytoplasm and intraluminal mucin with few floating cells (H&E stain, ×200). (C) Photomicrograph shows di-Periodic Acid-Schiff (PAS) positive for intraluminal mucins. Individual tumor cells had a hyperchromatic nucleus (PAS stain, ×200).



This study was presented as an e-poster at the 116th Annual Meeting of the Korean Ophthalmological Society 2016.

Conflicts of Interest The authors have no conflicts to disclose.


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