The Effect of Refractive Power on Retinal Volume Measurement Using Spectral Domain Optical Coherence Tomography

Myungshin Lee; Kiyeob Nam; Seunguk Lee; Sangjoon Lee

doi:10.3341/jkos.2018.59.2.153

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Lee, Nam, Lee, and Lee: The Effect of Refractive Power on Retinal Volume Measurement Using Spectral Domain Optical Coherence Tomography

Original Article

Journal of the Korean Ophthalmological Society 2018; 59(2): 153-158.

Published online: 9 February 2018

DOI: https://doi.org/10.3341/jkos.2018.59.2.153

The Effect of Refractive Power on Retinal Volume Measurement Using Spectral Domain Optical Coherence Tomography

Myungshin Lee, MD, Kiyeob Nam, MD, PhD, Seunguk Lee, MD, PhD, Sangjoon Lee, MD, PhD

Department of Ophthalmology, Kosin University College of Medicine, Busan, Korea.

Address reprint requests to Sangjoon Lee, MD, PhD. Department of Ophthalmology, Kosin University Gospel Hospital, #262 Gamcheon-ro, Seo-gu, Busan 49267, Korea. Tel: 82-51-990-6228, Fax: 82-51-990-3026, hhiatus@gmail.com

Received 6 July 2017 Revised 25 October 2017 Accepted 26 January 2018

The Korean Ophthalmological Society

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

To investigate the change of retinal volume according to anterior segment refractive power using contact lens by spectral domain optical coherence tomography (SD-OCT).

Methods

The retinal volume was measured using a SD-OCT (Heidelberg retinal angiography Spectralis + OCT, Heidelberg Engineering, Heidelberg, Germany) in 60 subjects without any underlying disease. The same examiner performed a 31-section macular volume-scan at 240 µm intervals, re-measured the same area by changing the refractive power of the anterior segment by wearing soft contact lenses of +6.0 diopters and −6.0 diopters. By using the ImageJ software to calculate the cross-sectional area and of the cross-sectional area and the volume was measured.

Results

The mean age of the participants was 25.6 ± 1.5 years and the mean axial length was 25.7 ± 1.57 mm. The volume of the posterior pole retina measured without the contact lens was 13.48 ± 0.05 and the mean volume of the retina measured with +6.0 diopter and −6.0 diopter contact lens in the same patient was 13.47 ± 0.07 mm³ and 13.48 ± 0.05 respectively. The mean volume was significantly lower(p = 0.036) in the measurement with the +6.0 diopter lens than in the measurement without the lens, and the mean volume was significantly higher in the measurement with the +6.0 diopter lens (p = 0.042). The change in retinal thickness was increased with longer axial length (r = 0.32, p < 0.05), but the central foveal thickness did not correlate with anterior corneal power (p = 0.463).

Conclusions

The volume of the retina measured using the SD-OCT is affected by the refractive power of the anterior segment and the axial length. Therefore, it is necessary to consider the change of refractive index because it can change the retinal volume measured by SD-OCT.

Keywords: Anterior segment power, Retinal volume, Spectral domain optical coherence tomography (SD-OCT)

Figures and Tables

Figure 1

Measurement of posterior pole retinal volume. (A) 31 sections of macular transverse volume scan and 8 × 7.2 mm of calculated area (red box). (B) The area to be measured was set by correcting the borderline error of the cross - sectional area from the basement membrane to the internal limiting memebrane in the cross section of the retina. (C) The width of the retina set (B) is shown in a schematic diagram and the width of the set area was measured using the Image j program (displayed as a red line).

Table 1

Study characteristics

Values are presented as mean ± SD unless otherwise indicated.

Table 2

Comparison of posterior pole retinal volume, central foveal thickness and retinal thickness measured by ETDRS circle with −6D of contact lens and +6D of contact lens to without any lens

Values are presented as mean ± SD unless otherwise indicated.

ETDRS = Early Treatment Diabetic Retinopathy Study; TMV = total macular volume measured by ETDRS circle; CSMT = central subfield macular thickness (1 mm).

^*Repeated-measure and one way analysis of variance; ^†Statistically significant difference between +6D group and plano group with Bonferroni post hoc test (p < 0.05); ^‡Statistically significant difference between plano group and −6D group with Bonferroni post hoc test (p < 0.05).

Table 3

Adjusted posterior pole retinal volume, central foveal thickness and retinal thickness measured by ETDRS circle with −6D of contact lens and +6D of contact lens to without any lens

Values are presented as mean ± SD unless otherwise indicated.

ETDRS = Early Treatment Diabetic Retinopathy Study; TMV = total macular volume measured by ETDRS circle.

^*Multivariate analysis (repeated-measure design) with test-retest variability as the within subject variance component; ^†Statistically significant difference between +6D group and plano group with Bonferroni post hoc test (p < 0.05); ^‡Statistically significant difference between plano group and −6D group with Bonferroni post hoc test (p < 0.05).

Notes

This paper is the result of research carried out with the funding of the 2017 Government (Future Creation Science Department) funded by the National Research Foundation of Korea (2017R1A2B4004664) and the research fund of the Kosin University College of Medicine Future Leading Research Project of 2016.

^{Conflicts of Interest} The authors have no conflicts to disclose.

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