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Eun and Cho: Two Cases of Corneal Neovascularization Improved by Electrocauterization and Subconjunctival Bevacizumab Injection
Case Report

Journal of the Korean Ophthalmological Society 2017; 58(8): 981-985.

Published online: 16 August 2017

DOI: https://doi.org/10.3341/jkos.2017.58.8.981

Two Cases of Corneal Neovascularization Improved by Electrocauterization and Subconjunctival Bevacizumab Injection

Jun Soo Eun, MD, Kyong Jin Cho, MD, PhD

Department of Ophthalmology, Dankook University College of Medicine, Cheonan, Korea.

Address reprint requests to Kyong Jin Cho, MD, PhD. Department of Ophthalmology, Dankook University Hospital, #201 Manghyang-ro, Dongnam-gu, Cheonan 31116, Korea. Tel: 82-41-550-6497, Fax: 82-41-556-0524, perfectcure@hanmail.net

Received 26 January 2017       Revised 22 June 2017       Accepted 28 July 2017

©2017 The Korean Ophthalmological Society

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

To report an experience of improving symptoms through treatment with electrocauterization and subconjunctival bevacizumab injection in two patients with keratitis accompanied by corneal neovascularization and opacity.

Case summary

(Case 1) A 20-year-old woman visited our institution complaining of binocular blurred vision and congestion for the previous 3 years. Her best corrected visual acuity (BCVA) was 0.07 in the right eye and 0.4 in the left eye (Han Chun-suk visual acuity chart, decimal). The diagnosis was bilateral rosacea keratitis. Antibiotics, steroid eye drops and oral antibiotics were administered, but no improvement was observed. Electrocauterization was performed at the origin of the neovascularization of the cornea and bevacizumab was injected at the peripheral subconjunctiva in the right eye. Thereafter the corneal neovascularization did not recur, corneal opacity was reduced, and BCVA improved to 0.5. (Case 2) A 19-year-old woman visited complaining of left eye congestion for the previous 3 years. Her BCVA was 1.0 in the right eye and 0.08 in the left eye.The diagnosis was phlyctenular keratitis of the left eye. Antibiotics, steroid eye drops and oral antibiotics were administered, but no improvement was observed. Therefore, electrocauterization and subconjunctival bevacizumab injection were performed in the cornea of the left eye, after which corneal neovascularization and opacity decreased.

Conclusions

In these cases, we report improvement of symptoms after treatment with electrocauterization and subconjunctival bevacizumab injection after failed treatment of palpebral sanitation, antibiotic and steroid.

Keywords: Bevacizumab, Electrocautery, Phlyctenular keratitis, Rosacea keratitis

Figures and Tables

Figure 1

20 years old woman with a history of rosacea keratitis. Color photographs of her right eye before electrocauterization and subconjunctival bevacizumab injection (A), bleaching vessels was shown in 2 weeks after treatment (B), 2 months after treatment, neovascularization did not recur and corneal opacity was significantly diminished in her cornea of the right eye (C).

jkos-58-981-g001
Figure 2

19 years old woman with a history of phlyctenular keratoconjunctivitis. Color photographs of her left eye before electrocauterization and subconjunctival bevacizumab injection (A), bleaching vessels was shown in 1 month after treatment (B), 1 year after treatment, neovascularization did not recur and corneal opacity was significantly diminished in her cornea of the left eye (C).

jkos-58-981-g002

Notes

The present research was conducted by the research fund of Dankook University in 2017.

Conflicts of Interest The authors have no conflicts to disclose.

References

1. Isner JM, Asahara T. Angiogenesis and vasculogenesis as therapeutic strategies for postnatal neovascularization. J Clin Invest. 1999; 103:1231–1236.
2. Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med. 1995; 1:27–31.
3. Burger PC, Chandler DB, Klintworth GK. Experimental corneal neovascularization: biomicroscopic, angiographic, and morphologic correlation. Cornea. 1985-1986; 4:35–41.
4. Cursiefen C, Küchle M, Naumann GO. Angiogenesis in corneal diseases: histopathologic evaluation of 254 human corneal buttons with neovascularization. Cornea. 1998; 17:611–613.
5. Chang JH, Gabison EE, Kato T, Azar DT. Corneal neovascularization. Curr Opin Ophthalmol. 2001; 12:242–249.
6. Borrie P. Rosacea with special reference to its ocular manifestations. Br J Dermatol. 1953; 65:458–463.
7. Starr PA, Macdonald A. Oculocutaneous aspects of rosacea. Proc R Soc Med. 1969; 62:9–11.
8. Jung JY, Kim JS. Comparison of optic disc appearance in anterior ischemic optic neuropathy and optic neuritis. J Korean Ophthalmol Soc. 2003; 44:157–161.
9. Abu el Asrar AM, Geboes K, Maudgal PC, et al. Immunocytological study of phlyctenular eye disease. Int Ophthalmol. 1987; 10:33–39.
10. Culbertson WW, Huang AJ, Mandelbaum SH, et al. Effective treatment of phlyctenular keratoconjunctivitis with oral tetracycline. Ophthalmology. 1993; 100:1358–1366.
11. Chen J, Liu W, Liu Z, et al. Expression of vascular endothelial growth factor and its receptors (flt-1) in morbid human corneas and investigation of its clinic importance. Yan Ke Xue Bao. 2002; 18:203–207.
12. Bahar I, Kaiserman I, McAllum P, et al. Subconjunctival bevacizumab injection for corneal neovascularization. Cornea. 2008; 27:142–147.
13. Gohto Y, Obana A, Kaneda K, Miki T. Photodynamic effect of a new photosensitizer ATX-S10 on corneal neovascularization. Exp Eye Res. 1998; 67:313–322.
14. Gerten G. Bevacizumab (avastin) and argon laser to treat neovascularization in corneal transplant surgery. Cornea. 2008; 27:1195–1199.
15. Pillai CT, Dua HS, Hossain P. Fine needle diathermy occlusion of corneal vessels. Invest Ophthalmol Vis Sci. 2000; 41:2148–2153.
16. Bock F, Köenig Y, Dietrich T, et al. Inhibition of angiogenesis in the anterior chamber of the eye. Ophthalmologe. 2007; 104:336–344.
17. Cursiefen C, Chen L, Saint-Geniez M, et al. Nonvascular VEGF receptor 3 expression by corneal epithelium maintains avascularity and vision. Proc Natl Acad Sci U S A. 2006; 103:11405–11410.
18. Phillips K, Arffa R, Cintron C, et al. Effects of prednisolone and medroxyprogesterone on corneal wound healing, ulceration, and neovascularization. Arch Ophthalmol. 1983; 101:640–643.
19. Baer JC, Foster CS. Corneal laser photocoagulation for treatment of neovascularization. Efficacy of 577 nm yellow dye laser. Ophthalmology. 1992; 99:173–179.
20. Primbs GB, Casey R, Wamser K, et al. Photodynamic therapy for corneal neovascularization. Ophthalmic Surg Lasers. 1998; 29:832–838.
21. Cursiefen C, Chen L, Borges LP, et al. VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment. J Clin Invest. 2004; 113:1040–1050.
22. Amano S, Rohan R, Kuroki M, et al. Requirement for vascular endothelial growth factor in wound- and inflammation-related corneal neovascularization. Invest Ophthalmol Vis Sci. 1998; 39:18–22.
23. Zheng M, Deshpande S, Lee S, et al. Contribution of vascular endothelial growth factor in the neovascularization process during the pathogenesis of herpetic stromal keratitis. J Virol. 2001; 75:9828–9835.
24. Chu HS, Hu FR, Yang CM, et al. Subconjunctival injection of bevacizumab in the treatment of corneal neovascularization associated with lipid deposition. Cornea. 2011; 30:60–66.
25. Zaki AA, Farid SF. Subconjunctival bevacizumab for corneal neovascularization. Acta Ophthalmol. 2010; 88:868–871.
26. Mimura T, Amano S, Usui T, et al. Expression of vascular endothelial growth factor C and vascular endothelial growth factor receptor 3 in corneal lymphangiogenesis. Exp Eye Res. 2001; 72:71–78.
27. Singh D, Singh K. Transciliary filtration using the fugo blade TM. Ann Ophthalmol. 2002; 34:183–187.
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