Solitary Neurofibroma Occurred on the Eyelid Margin without Neurofibromatosis: A Case Report

Yeon Soo Kang; Won Choi; Ga Eon Kim; Kyung Chul Yoon

doi:10.3341/jkos.2017.58.2.222

Journal List > J Korean Ophthalmol Soc > v.58(2) > 1010707

Go to TopGo to Top Go to BottomGo to Bottom

TOOLS

Kang, Choi, Kim, and Yoon: Solitary Neurofibroma Occurred on the Eyelid Margin without Neurofibromatosis: A Case Report

Original Article

J Korean Ophthalmol Soc 2017;58(2):222-225.

Published online: 8 September 2017

DOI: https://doi.org/10.3341/jkos.2017.58.2.222

Solitary Neurofibroma Occurred on the Eyelid Margin without Neurofibromatosis: A Case Report

Yeon Soo Kang, M.D.¹, Won Choi, M.D.¹, Ga Eon Kim, M.D.², Kyung Chul Yoon, MD, PhD^1,

¹Department of Ophthalmology, Chonnam National University Medical School, Gwangju, Korea

²Department of Pathology, Chonnam National University Medical School, Gwangju, Korea

Address reprint requests to Kyung Chul Yoon, MD, PhD Department of Ophthalmology, Chonnam National University Hospital, #42 Jebong-ro, Dong-gu, Gwangju 61469, Korea Tel: 82-62-220-6741, Fax: 82-62-227-1642 E-mail: kcyoon@jnu.ac.kr

Received 28 July 201616 November 2016 Accepted 14 January 2017

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

We report a rare case of solitary neurofibroma on the eyelid margin without neurofibromatosis.

Case summary

A 46-year-old male presented with a well-define small nodular lesion on the right upper eyelid margin that had not changed for 10 years. Surgical excision and biopsy were performed. Histological examination showed spindle-shaped cells in the fibrous stroma on hematoxylin & eosin staining, and immunohistochemical staining revealed S-100 protein-positive cells. Dermatologic, neurologic, and genetic evaluations showed no evidence of systemic neurofibromatosis. Six months after oper-ation, there was no evidence of local recurrence.

Conclusions

To the best of our knowledge, this is the first case of solitary neurofibroma involving the eyelid margin without neu-rofibromatosis in Korea. Neurofibroma should be considered in a differential diagnosis of eyelid mass and can be successfully managed with surgical excision.

Keywords: Eyelid mass, Neurofibroma, Neurofibromatosis

References

1. Kamra HT, Dantkale SS, Birla K. . Plexiform neurofibroma in the submandibular gland along with small diffuse neurofibroma in the floor of the mouth but without neurofibromatosis-1: a rare case report. Ecancermedicalscience. 2013; 7:313.

2. Lee KH, Park JW, Yoon KC. A case of neurofirbromatosis of the orbit and ocular surface. J Korean Ophthalmol Soc. 2007; 48:1276–80.

3. Berney C, Spahn B, Oberhansli C. . Multiple intraorbital neu-rofibromas: a rare cause of proptosis. Klin Monbl Augenheilkd. 2004; 221:418–20.

4. Hah MC, Han YJ, Hong SH. A case of eyelid neurofibroma in yon Recklinghausen’s disease. J Korean Ophthalmol Soc. 1974; 15:361–3.

5. Cho BC, Chun YK. A case of neurofibromatosis. J Korean Ophthalmol Soc. 1985; 26:393–8.

6. Jo YJ, Lee SB, Kwon HJ. . Inducible dynamic proptosis in a neurofibromatosis patient with arachnoid cyst. J Korean Ophthalmol Soc. 2011; 52:93–6.

7. Jung JW, Lee JH, Shyn KH, Chi MJ. A case of plexiform neuro-fibroma with severe ptosis and proptosis. J Korean Ophthalmol Soc. 2007; 48:725–30.

8. Stagner AM, Jakobiec FA. Peripheral nerve sheath tumors of the eyelid dermis: a clinicopathologic and immunohistochemical analysis. Ophthal Plast Reconstr Surg. 2016; 32:40–5.

9. Bechtold D, Hove HD, Prause JU. . Plexiform neurofibroma of the eye region occurring in patients without neurofibromatosis type 1. Ophthal Plast Reconstr Surg. 2012; 28:413–5.

10. Shibata N, Kitagawa K, Noda M, Sasaki H. Solitary neurofibroma without neurofibromatosis in the superior tarsal plate simulating a chalazion. Graefes Arch Clin Exp Ophthalmol. 2012; 250:309–10.

11. Han HJ, Lee HO, Ma KH. A case of solitary neurofibroma. J Korean Ophthalmol Soc. 1981; 22:575–9.

12. Abdolrahimzadeh B, Piraino DC, Albanese G. . Neurofibro- matosis: an update of ophthalmic characteristics and applications of optical coherence tomography. Clin Ophthalmol. 2016; 10:851–60.

13. Ferner RE. The neurofibromatoses. Pract Neurol. 2010; 10:82–93.

14. Kim SU, Gu MJ, Lee JK, Park DJ. A case of bulbar conjunctival schwannoma. J Korean Ophthalmol Soc. 2009; 50:1111–4.

15. Dailey RA, Sullivan SA, Wobig JL. Surgical debulking of eyelid and anterior orbital plexiform neurofibromas by means of the car-bon dioxide laser. Am J Ophthalmol. 2000; 130:117–9.

16. Choi CK, Kwak YS. A case of neurofibromatosis with pulsating exophthalmos. J Korean Ophthalmol Soc. 1976; 17:525–9.

Figure 1.

Clinical photographs of a 46-year-old man. There was well-defined nodular lesion in the right upper eyelie margin (A, B).

Figure 2.

Histologic examination of the patient. (A) Hematoxylin and eosin stained section (×200) shows spindle shaped cells in the fibrous stroma. (B) Immunohistochemical staining (×200) reveales S-100 protein positive cells.

Figure 3.

Photographs of 6 months after operation. There was no evidence of local recurrence at the operation site (A, B).

TOOLS

Similar articles