Comparison of Inner Retinal Thickness between the Fellow Eyes of Unilateral Branch Retinal Vein Occlusion and Normal Control

Gyu Chul Chung; Dong Eun Lee; Chang Ki Yoon; Hyun Woong Kim; Jung Lim Kim

doi:10.3341/jkos.2017.58.2.165

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Chung, Lee, Yoon, Kim, and Kim: Comparison of Inner Retinal Thickness between the Fellow Eyes of Unilateral Branch Retinal Vein Occlusion and Normal Control

Original Article

J Korean Ophthalmol Soc 2017;58(2):165-170.

Published online: 8 September 2017

DOI: https://doi.org/10.3341/jkos.2017.58.2.165

Comparison of Inner Retinal Thickness between the Fellow Eyes of Unilateral Branch Retinal Vein Occlusion and Normal Control

Gyu Chul Chung, M.D.^1,², Dong Eun Lee, M.D.^1,², Chang Ki Yoon, M.D.^1,², Hyun Woong Kim, M.D., PhD¹, Jung Lim Kim, M.D., PhD^1,^2,

¹Department of Ophthalmology, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea

²Therapeutics Center for Ocular Neovascular Disease, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea

Address reprint requests to Jung Lim Kim, MD, PhD Department of Ophthalmology, Inje University Busan Paik Hospital, #75 Bokji-ro, Busanjin-gu, Busan 47392, Korea Tel: 82-51-890-6016, Fax: 82-51-890-6329 E-mail: pcheck@hanmail.net

This study was supported by a grant from the Korea Healthcare Technology R&D Project, Ministry of Health and Welfare Affairs, Republic of Korea (grant #: HI15C1142).

Received 25 August 20163 November 2016 Accepted 18 January 2017

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

The purpose of this study was to compare inner retinal thickness and retinal nerve fiber layer (RNFL) thickness be-tween fellow eyes with unilateral branch retinal vein occlusion (BRVO) and normal control eyes.

Methods

Retrospective cross-sectional study including 59 patients diagnosed with unilateral BRVO and 51 control subjects. Using spectral domain optical coherence tomography, we investigated the average, 4 quadrant, and 12 clock-hour RNFL thick-nesses and the average, minimum, superior, superonasal, superotemporal, inferior, inferonasal, and inferotemporal thicknesses of the ganglion cell-inner plexiform layer (GCIPL) layer.

Results

Patients with unilateral BRVO had a higher incidence of hypertension. In the fellow eyes of the unilateral BRVO pa-tients, 7 and 11 o’clock RNFL thicknesses were significantly thinner than for the control eyes. There was no significant difference in the GCIPL thickness between the two groups

Conclusions

The RNFL thickness of the fellow eyes of the unilateral BRVO patients showed significant decreases in the 7 and 11 o’clock sectors ( p=0.005, 0.017, respectively), whereas there was no significant difference in the GCIPL thickness between the two groups. In the RNFL thickness analysis, the 7 and 11 o’clock sectors were found to be dominant locations of decreased RNFL thickness for the open angle glaucoma. Further, glaucomatous change should be carefully monitored in the fellow eyes of unilateral BRVO patients.

Keywords: Fellow eye, Ganglion cell layer thickness, Glaucoma, Retinal nerve fiber layer thickness, Unilateral retinal vein occlusion

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Figure 1.

Photographs of the retinal nerve fiber layer (RNFL) of a 65 year old man with branch retinal vein occlusion (BRVO) (A, B). This patient had BRVO in the left eye (B) and red-free fundus photography showed a wedge-shaped defect (between arrows) in the right eye (A). Optical coherence tomography (C) of the right eye showed that RNFL thickness was identified as abnormal by the <1% criterion from 10-o’clock to 11-o’clock area. Ganglion cell analysis map of the right eye showed thinning of the ganglion cell-inner plexiform layer (red color area) on deviation map of right eye. A glaucomatous visual field change was noted in the corre-sponding hemifield location (D). TEMP = temporal; SUP = superior; NAS = nasal; INF = inferior; S = superior; N = nasal; I = inferior; T = temporal; MD = mean deviation; PSD = pattern standard deviation.

Table 1.

Characteristics of RVO fellow eyes and control groups

	RVO Fellow eye (n = 59)	Control (n = 48)	p-value
Age (years)	63.4 ± 9.6	62.9 ± 9.8	0.763^*
Gender (male/female)	18/41	15/33	0.934^†
Hypertension (n)	30	13	0.013^†
Diabetes mellitus (n)	12	3	0.037^†
Refraction (D)	-0.12 ± 1.51	0.16 ± 1.09	0.204^*
Mean IOP (mmHg)	14.98 ± 3.17	15.73 ± 3.69	0.234^*

Values are presented as mean ± SD unless otherwise indicated.

RVO = retinal vein occlusion; D = diopter; IOP = intraocular pressure.

^* By student t-test

^† By chi-square test.

Table 2.

Comparison between RNFL thickness in the fellow eyes of RVO patients and controls

RNFL thickness (μ m)	RVO fellow eye (μ m) (n = 59)	Control (μ m) (n = 48)	p-value^*
Average RNFL thickness	87.87 ± 11.09	89.00 ± 7.46	0.705
Superior quadrant	107.29 ± 17.05	109.28 ± 15.06	0.286
Nasal quadrant	63.85 ± 8.98	66.34 ± 7.06	0.104
Inferior quadrant	111.91 ± 22.05	114.69 ± 12.38	0.551
Temporal quadrant	65.97 ± 10.54	65.51 ± 9.70	0.821
1-o’clock	101.04 ± 21.35	100.45 ± 22.18	0.390
2-o’clock	75.51 ± 14.94	77.52 ± 13.23	0.704
3-o’clock	55.73 ± 7.87	55.62 ± 7.98	0.764
4-o’clock	60.36 ± 10.00	61.76 ± 8.08	0.688
5-o’clock	105.43 ± 26.40	105.75 ± 24.28	0.911
6-o’clock	121.73 ± 22.54	123.39 ± 28.43	0.871
7-o’clock	118.04 ± 22.16	134.87 ± 18.40	0.005
8-o’clock	67.28 ± 14.34	66.91 ± 13.48	0.684
9-o’clock	54.93 ± 8.65	54.62 ± 7.80	0.391
10-o’clock	75.32 ± 13.35	76.19 ± 14.94	0.704
11-o’clock	112.59 ± 21.83	124.24 ± 17.42	0.017
12-o’clock	118.49 ± 19.24	115.76 ± 20.51	0.063

Values are presented as mean ± SD unless otherwise indicated.

RNFL = retinal nerve fiber layer; RVO = retinal vein occlusion.

^* By student t-test.

Table 3.

Comparison between GCIPL thickness in the fellow eyes of RVO patients and controls

GCIPL thickness (μ m)	RVO Fellow eye (μ m) (n = 59)	Control (μ m) (n = 48)	p-value^*
Average	79.05 ± 11.22	80.08 ± 6.64	0.640
Minimum	73.52 ± 13.97	76.77 ± 8.91	0.223
Superornasal	81.46 ± 12.33	81.33 ± 7.36	0.995
Superior	79.32 ± 12.07	80.23 ± 6.23	0.375
Superotemporal	78.43 ± 11.63	79.33 ± 5.99	0.223
Inferotemporal	79.51 ± 10.46	80.54 ± 7.47	0.600
Inferior	76.68 ± 12.64	79.29 ± 7.06	0.395
Inferonasal	78.13 ± 13.04	79.37 ± 8.94	0.986

Values are presented as mean ± SD unless otherwise indicated.

GCIPL = ganglion cell-inner plexiform layer; RVO = retinal vein occlusion.

^* By student t-test.

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