Journal List > J Korean Ophthalmol Soc > v.58(11) > 1010675

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Park, Jung, Lee, Park, Lee, and Byon: Hyper-proliferation of Glial Tissues Following Autologous Internal Limiting Membrane Transplantation in Idiopathic Large Macular Holes
Case Report

Journal of the Korean Ophthalmological Society 2017; 58(11): 1307-1312.

Published online: 15 November 2017

DOI: https://doi.org/10.3341/jkos.2017.58.11.1307

Hyper-proliferation of Glial Tissues Following Autologous Internal Limiting Membrane Transplantation in Idiopathic Large Macular Holes

Jong Ho Park, MD1, 2, Jae Woo Jung, MD1, Seung Min Lee, MD1, 2, Sung Who Park, MD3, 4, 5, Ji Eun Lee, MD, PhD3, 4, 5, Ik Soo Byon, MD1, 2, 5

1Department of Ophthalmology, Pusan National University Yangsan Hospital, Yangsan, Korea.

2Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea.

3Department of Ophthalmology, Pusan National University Hospital, Busan, Korea.

4Medical Research Institute, Pusan National University Hospital, Busan, Korea.

5Department of Ophthalmology, Pusan National University School of Medicine, Yangsan, Korea.

Address reprint requests to Ik Soo Byon, MD. Department of Ophthalmology, Pusan National University Yangsan Hospital, #20 Geumo-ro, Mulgeum-eup, Yangsan 50612, Korea. Tel: 82-55-360-2592, Fax: 82-55-360-2161, isbyon@pusan.ac.kr

Received 20 July 2017       Revised 20 September 2017       Accepted 26 October 2017

©2017 The Korean Ophthalmological Society

The Korean Ophthalmological Society

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

To report three cases of glial hyper-proliferation after autologous internal limiting membrane (ILM) transplantation in idiopathic large macular holes.

Case Summary

Three eyes with full thickness macular holes >500 µm underwent autologous ILM transplantation. After surgery, the macular hole was closed and foveal contour was U-shaped. Optical coherence tomography revealed long-lasting proliferation of glial cells in the fovea after the hole closure. This glial proliferation continued for 6 months, with improved visual acuity, and bump-like features of the fovea.

Conclusions

Autologous transplantation of ILM effectively induced long-lasting proliferation of glial cells, thereby achieving the closure of large macular holes. However, an abnormality of the foveal contour may develop after the hole closure in some cases.

Keywords: Autologous internal limiting membrane transplantation, Glial cell, Hyper-proliferation, Macular hole

Figures and Tables

Figure 1

A Case of 67-year-old woman with full thickness macular hole. Two weeks after autologous internal limiting membrane transplantation, optical coherence tomography images showed a glial tissues in the fovea without a complete hole closure. The long-lasting proliferation of glial cells (yellow arrows) resulted in the closure of hole, but the abnormal contour of fovea was postoperatively observed from 3 months to 24 months. The defects of ellipsoid zone (black arrowheads) and external limiting membrane (white arrowheads) remained. The foveal depigmentation was seen in the postoperative fundus photographs.

jkos-58-1307-g001
Figure 2

A case of 70-year-old woman with full thickness macular hole. One month after autologous internal limiting membrane transplantation, the closure of the hole and glial tissues in fovea (yellow arrow) were observed in optical coherence tomography. Foveal depigmentation was seen in fundus photography. At 6 months, the protrusion of fovea developed. The defects of ellipsoid zone (black arrowheads) and external limiting membrane (white arrowheads) remained.

jkos-58-1307-g002
Figure 3

A case of 75-year-old woman with full thickness macular hole. One month after autologous internal limiting membrane transplantation, irregular contour of fovea (yellow arrows) was detected in optical coherence tomography. At 3 months, the bump-like fovea developed. The depigmentation of fovea was seen in postoperative fundus photograph. The defects of ellipsoid zone (black arrowheads) and external limiting membrane (white arrowheads) remained. And it lasted until 6 months.

jkos-58-1307-g003

Notes

Conflicts of Interest The authors have no conflicts to disclose.

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