Journal List > J Korean Ophthalmol Soc > v.58(10) > 1010650

J Korean Ophthalmol Soc. 2017 Oct;58(10):1160-1168. Korean.
Published online October 11, 2017.  https://doi.org/10.3341/jkos.2017.58.10.1160
©2017 The Korean Ophthalmological Society
Retinal Nerve Fiber Layer Thickness Measurement Using Swept Source Optical Coherence Tomography in Healthy Korean
Soon Ho Choi, MD,1 Young-Hoon Ohn, MD, PhD,2 and Ka Hee Park, MD2
1Department of Ophthalmology, Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Korea.
2Department of Ophthalmology, Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea.

Address reprint requests to Ka Hee Park, MD. Department of Ophthalmology, Soonchunhyang University Bucheon Hospital, #170 Jomaru-ro, Bucheon 14584, Korea. Tel: 82-32-621-5053, Fax: 82-32-621-5435, Email: ophkh@schmc.ac.kr
Received March 23, 2017; Revised August 14, 2017; Accepted September 25, 2017.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.


Abstract

Purpose

To investigate retinal nerve fiber layer (RNFL) thickness using swept source (SS)-optical coherence tomography (OCT) in healthy Koreans and to evaluate the effects of age on the distributional variability of thickness.

Methods

We performed a retrospective review of 309 normal eyes presenting for examination of peripapillary nerve fiber layer thickness measured by SS-OCT (DRI OCT-1, Atlantis SS-OCT, Topcon, Tokyo, Japan) from July 2014 to February 2016. The patients were between the ages of 20 and 79 without systemic or ocular disease. The patients were divided into 3 age groups of 20 to 39 years (85 eyes), 40 to 59 years (140 eyes), and 60 to 79 years (84 eyes). The groups were matched based on average RNFL thickness and quadrant and 12 o'clock position RNFL thickness.

Results

The average RNFL thickness of the inferior quadrant was the thickest of the layers and revealed a bimodal distribution. In the three groups, the thicknesses of the average RNFL, quadrant, and 12 o'clock RNFL decreased with age. There was significant difference in the measurements (p < 0.05) of quadrant RNFL thickness except that in the nasal quadrant (p = 0.068).

Conclusions

The thickness of the circumpapillary retinal nerve fiber layer measured by SS-OCT differs according to age and analysis of normal values by age can be useful in the diagnosis of disease.

Keywords: Korean; Retinal nerve fiber layer thickness; Swept source optical coherence tomography

Figures


Figure 1
Scatterplot of mean and 4 quadrant retinal nerve fiver layer (RNFL) thickness according to age. (A-E) All graphs represent a decreasing tendency of thickness by aging. CI = confidence interval.
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Figure 2
Distribution of Retinal nerve fiber layer (RNFL) thickness according to group. This schimatized graph represent the it is thinner in the older age group.
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Figure 3
Scatterplot of 12 clock-hour sectors of retinal nerve fiber layer thickness (RNFL) according to age. (A-L) All graphs represent a decreasing tendency of thickness by aging. CI = confidence interval.
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Figure 4
Distribution of retinal nerve fiber layer thickness (RNFL) thickness according to age (group by 10's). This schimatized graph represent the it is thinner in the older age group.
Click for larger image

Tables


Table 1
Subject distribution by age group
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Table 2
Distribution of RNFL thickness in the 4 quadrants and 12 clock-hour sectors
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Table 3
Slopes and annual rates of decrease for mean, 4 quadrants, and 12 clock-hour sectors RNFL thickness
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Table 4
Distribution of RNFL thickness in the 4 quadrants and 12 clock-hour sectors (Group by 10's)
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Table 5
Comparison of RNFL thickness with other research in Korea
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Notes

Conflicts of Interest:The authors have no conflicts to disclose.

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