Retinal Nerve Fiber Layer Thickness Measurement Using Swept Source Optical Coherence Tomography in Healthy Korean

Soon Ho Choi; Young-Hoon Ohn; Ka Hee Park

doi:10.3341/jkos.2017.58.10.1160

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Choi, Ohn, and Park: Retinal Nerve Fiber Layer Thickness Measurement Using Swept Source Optical Coherence Tomography in Healthy Korean

Original Article

Journal of the Korean Ophthalmological Society 2017; 58(10): 1160-1168.

Published online: 11 October 2017

DOI: https://doi.org/10.3341/jkos.2017.58.10.1160

Retinal Nerve Fiber Layer Thickness Measurement Using Swept Source Optical Coherence Tomography in Healthy Korean

Soon Ho Choi, MD¹, Young-Hoon Ohn, MD, PhD², Ka Hee Park, MD²

¹Department of Ophthalmology, Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Korea.

²Department of Ophthalmology, Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea.

Address reprint requests to Ka Hee Park, MD. Department of Ophthalmology, Soonchunhyang University Bucheon Hospital, #170 Jomaru-ro, Bucheon 14584, Korea. Tel: 82-32-621-5053, Fax: 82-32-621-5435, ophkh@schmc.ac.kr

Received 23 March 2017 Revised 14 August 2017 Accepted 25 September 2017

The Korean Ophthalmological Society

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

To investigate retinal nerve fiber layer (RNFL) thickness using swept source (SS)-optical coherence tomography (OCT) in healthy Koreans and to evaluate the effects of age on the distributional variability of thickness.

Methods

We performed a retrospective review of 309 normal eyes presenting for examination of peripapillary nerve fiber layer thickness measured by SS-OCT (DRI OCT-1, Atlantis SS-OCT, Topcon, Tokyo, Japan) from July 2014 to February 2016. The patients were between the ages of 20 and 79 without systemic or ocular disease. The patients were divided into 3 age groups of 20 to 39 years (85 eyes), 40 to 59 years (140 eyes), and 60 to 79 years (84 eyes). The groups were matched based on average RNFL thickness and quadrant and 12 o'clock position RNFL thickness.

Results

The average RNFL thickness of the inferior quadrant was the thickest of the layers and revealed a bimodal distribution. In the three groups, the thicknesses of the average RNFL, quadrant, and 12 o'clock RNFL decreased with age. There was significant difference in the measurements (p < 0.05) of quadrant RNFL thickness except that in the nasal quadrant (p = 0.068).

Conclusions

The thickness of the circumpapillary retinal nerve fiber layer measured by SS-OCT differs according to age and analysis of normal values by age can be useful in the diagnosis of disease.

Keywords: Korean, Retinal nerve fiber layer thickness, Swept source optical coherence tomography

Figures and Tables

Figure 1

Scatterplot of mean and 4 quadrant retinal nerve fiver layer (RNFL) thickness according to age. (A-E) All graphs represent a decreasing tendency of thickness by aging. CI = confidence interval.

Figure 2

Distribution of Retinal nerve fiber layer (RNFL) thickness according to group. This schimatized graph represent the it is thinner in the older age group.

Figure 3

Scatterplot of 12 clock-hour sectors of retinal nerve fiber layer thickness (RNFL) according to age. (A-L) All graphs represent a decreasing tendency of thickness by aging. CI = confidence interval.

Figure 4

Distribution of retinal nerve fiber layer thickness (RNFL) thickness according to age (group by 10's). This schimatized graph represent the it is thinner in the older age group.

Table 1

Subject distribution by age group

Values are presented as mean ± SD unless otherwise indicated.

M = male; F = female; BCVA = best corrected visual acuity.

^*One-way analysis of variance (ANOVA).

Table 2

Distribution of RNFL thickness in the 4 quadrants and 12 clock-hour sectors

Values are presented as mean ± SD unless otherwise indicated.

RNFL = retinal nerve fiber layer; S = superior; T = temporal; N = nasal; I = inferior.

Table 3

Slopes and annual rates of decrease for mean, 4 quadrants, and 12 clock-hour sectors RNFL thickness

RNFL = retinal nerve fiber layer; CI = confidence interval; S = superior; T = temporal; N = nasal; I = inferior.

Table 4

Distribution of RNFL thickness in the 4 quadrants and 12 clock-hour sectors (Group by 10's)

Values are presented as mean ± SD unless otherwise indicated. RNFL = retinal nerve fiber layer; T = temporal; S = superior; N = nasal; I = inferior.

Table 5

Comparison of RNFL thickness with other research in Korea

Values are presented as mean ± SD unless otherwise indicated.

RNFL = retinal nerve fiber layer; n = number of eyes.

^*Unpaired t-test.

Notes

^{Conflicts of Interest} The authors have no conflicts to disclose.

References

1. Banister K, Boachie C, Bourne R, et al. Can automated imaging for optic disc and retinal nerve fiber layer analysis aid glaucoma detection? Ophthalmology. 2016; 123:930–938.

2. Reus NJ, Lemij HG, Garway-Heath DF, et al. Clinical assessment of stereoscopic optic disc photographs for glaucoma: the European Optic Disc Assessment Trial. Ophthalmology. 2010; 117:717–723.

3. Quigley HA, Dunkelberger GR, Green WR. Retinal ganglion cell atrophy correlated with automated perimetry in human eyes with glaucoma. Am J Ophthalmol. 1989; 107:453–464.

4. Sihota R, Sony P, Gupta V, et al. Diagnostic capability of optical coherence tomography in evaluating the degree of glaucomatous retinal nerve fiber damage. Invest Ophthalmol Vis Sci. 2006; 47:2006–2010.

5. Kampougeris G, Spyropoulos D, Mitropoulou A, et al. Peripapillary retinal nerve fibre layer thickness measurement with SD-OCT in normal and glaucomatous eyes: distribution and correlation with age. Int J Ophthalmol. 2013; 6:662–665.

6. Hong S, Seong GJ, Kim SS, et al. Comparison of peripapillary retinal nerve fiber layer thickness measured by spectral vs. time domain optical coherence tomography. Curr Eye Res. 2011; 36:125–134.

7. Yang Z, Tatham AJ, Zangwill LM, et al. Diagnostic ability of retinal nerve fiber layer imaging by swept-source optical coherence tomography in glaucoma. Am J Ophthalmol. 2015; 159:193–201.

8. Ha A, Lee SH, Lee EJ, Kim TW. Retinal nerve fiber layer thickness measurement comparison using spectral domain and swept source optical coherence tomography. Korean J Ophthalmol. 2016; 30:140–147.

9. Leem HS, Paik DJ, Kim HC. Morphological analysis of papillary retinal vessels and retinal nerve fiber layer in Koreans. J Korean Ophthalmol Soc. 2007; 48:1369–1378.

10. Lee JH, Ahn CS, Lee DY. Quantification of retinal nerve fiber layer thickness in the normal subjects using optical coherence tomography. J Korean Ophthalmol Soc. 1999; 40:2804–2815.

11. Savini G, Carbonelli M, Barboni P. Retinal nerve fiber layer thickness measurement by Fourier-domain optical coherence tomography: a comparison between cirrus-HD OCT and RTVue in healthy eyes. J Glaucoma. 2010; 19:369–372.

12. Chang RT, Knight OJ, Feuer WJ, Budenz DL. Sensitivity and specificity of time-domain versus spectral-domain optical coherence tomography in diagnosing early to moderate glaucoma. Ophthalmology. 2009; 116:2294–2299.

13. Patel NB, Wheat JL, Rodriguez A, et al. Agreement between retinal nerve fiber layer measures from Spectralis and Cirrus spectral domain OCT. Optom Vis Sci. 2012; 89:E652–E666.

14. Knight OJ, Chang RT, Feuer WJ, Budenz DL. Comparison of retinal nerve fiber layer measurements using time domain and spectral domain optical coherent tomography. Ophthalmology. 2009; 116:1271–1277.

15. Bayraktar S, Bayraktar Z, Yilmaz OF. Influence of scan radius correction for ocular magnification and relationship between scan radius with retinal nerve fiber layer thickness measured by optical coherence tomography. J Glaucoma. 2001; 10:163–169.

16. Song TG, Yoo YC, Lee HB. Quantitative analysis of retinal nerve fiber layer thickness profile in myopic eyes. J Korean Ophthalmol Soc. 2009; 50:1840–1846.

17. Leung CK, Mohamed S, Leung KS, et al. Retinal nerve fiber layer measurements in myopia: An optical coherence tomography study. Invest Ophthalmol Vis Sci. 2006; 47:5171–5176.

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