Retinal Hemorrhage Incidence of Newborn with Intra-uterine Growth Retardation in Korea

Joo Jin-Ho; Kim Young-Gyoon

doi:10.3341/jkos.2017.58.1.113

Journal List > J Korean Ophthalmol Soc > v.58(1) > 1010645

Go to TopGo to Top Go to BottomGo to Bottom

TOOLS

Jin-Ho and Young-Gyoon: Retinal Hemorrhage Incidence of Newborn with Intra-uterine Growth Retardation in Korea

Original Article

J Korean Ophthalmol Soc 2015;58(1):113-116.

Published online: 30 August 2015

DOI: https://doi.org/10.3341/jkos.2017.58.1.113

Retinal Hemorrhage Incidence of Newborn with Intra-uterine Growth Retardation in Korea

Joo Jin-Ho, M.D, Kim Young-Gyoon, MD, PhD

Department of Ophthalmology, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul, Korea

Address reprint requests to Young-Gyoon Kim, MD, PhD Department of Ophthalmology, Kyung Hee University Hospital at Gangdong, #892 Dongnam-ro, Gangdong-gu, Seoul 05278, Korea Tel: 82-2-440-7751, Fax: 82-2-440-7756 E-mail: eyedockim@naver.com

Received 30 June 20167 October 2016 Accepted 15 December 2016

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

We report 3 cases of patients with retinal hemorrhage among 27 newborns with intrauterine growth retardation.

Case summary

Twenty-seven newborns with intrauterine growth retardation were examined using the indirect ophthalmoscope for confirming retinal hemorrhage which was observed in 3 patients. The mean gestational age and birth weight (g) of the 3 pa-tients were 37⁺⁶ weeks and 2,086.7 g, respectively. Among the 3 newborns, 1 patient’s mother had oligohydramnios. Two pa-tients were delivered vaginally and 1 by cesarean section. All 3 patients had no birth trauma and the retinal hemorrhage was re-solved within 2 weeks after the first eye examination.

Conclusions

We observed 3 cases with retinal hemorrhage in neonates with intrauterine growth retardation which improved within 2 weeks.

Keywords: Intra-uterine growth retardation (IUGR), Neonate, Retinal Hemorrhage

References

1. Watts P, Maguire S, Kwok T, et al. Newborn retinal hemorrhages: a systematic review. J AAPOS. 1961; 66:111–24.

2. Zhao Q, Zhang Y, Yang Y, et al. Birth-related retinal hemorrhages in healthy full-term newborns and their relationship to maternal, obstetric, and neonatal risk factors. Graefes Arch Clin Exp Ophthalmol. 1961; 66:111–24.

3. Kim KH, Rhee MG, Shin TY. Retinal hemorrhages in newborn infants. J Korean Ophthalmol Soc. 1961; 66:111–24.

4. Park SY, Kim SY. Findings of eye screening examinations with wide-field digital imaging system in healthy newborns. J Korean Ophthalmol Soc. 1961; 66:111–24.

5. Wollmann HA. Intrauterine growth restriction: definition and etiology. Horm Res. 1998; 49(Suppl 2):1–6.

6. Ghekiere S, Allegaert K, Cossey V, et al. Ophthalmological find-ings in congenital cytomegalovirus infection: when to screen, when to treat? J Pediatr Ophthalmol Strabismus. 1961; 66:111–24.

7. Yoser SL, Forster DJ, Rao NA. Systemic viral infections and their retinal and choroidal manifestations. Surv Ophthalmol. 1993; 37:313–52.

8. Luo R, Liu J, Hu P, et al. Results of 779 cases of neonatal fundus screening and risk factors for neonatal fundus diseases. Zhongguo Dang Dai Er Ke Za Zhi. 1961; 66:111–24.

Table 1.

The results of eye examinations and demographics in 27 newborns with IUGR

No.	GA	BW (g)	Maternal factor	Obstetric factor	Neonatal factor	RH	Complete resolved period
1	37	1,920	-	C-sec	-	-
2	34⁺⁶	1,540	PIH	VD	Discordant twin	-
3	39⁺¹	2,075	Oligohydramnios	C-sec	Hyperbilirubin, TTN	-
4	35	1,720	PIH	VD	-	-
5	40⁺³	2,040	-	VD	Hyperbilirubin	-
6	35⁺²	1,990	PIH	C-sec	-	-
7	37⁺²	2,290	Oligohydramnios	VD	Jaundice	OU	2 weeks
8	33⁺⁴	1,200	-	C-sec	Hyperbilirubin	-
9	36	1,600	-	VD	Hyperbilirubin, anemia	-
10	38⁺²	1,640	-	C-sec	-	-
11	41	2,040	-	VD	Hyperbilirubin, Cephalhematoma	OU	2 weeks
12	36⁺³	1,930	-	C-sec	Twin	-
13	38⁺¹	1,940	Oligohydramnios	C-sec	Hyperbilirubin, Anemia, Down syndrome	-
14	27⁺⁵	720	PIH	C-sec	Anemia	-
15	35⁺⁰	1,670	-	C-sec	-	-
16	38⁺⁴	2,140	-	C-sec	-	-
17	39⁺⁵	2,480	Oligohydramnios	C-sec	Anemia	-
18	35	1,700	-	C-sec	-	-
19	36⁺⁶	1,420	-	VD	Hyperbilirubin	-
20	37⁺¹	2,420	-	C-sec	-	-
21	35⁺¹	1,930	-	C-sec	-	OU	2 weeks
22	39⁺³	2,420	-	C-sec	TTN, Hyperbilirubin	-
23	36⁺⁵	1,690	Oligohydramnios	C-sec	TTN, Hyperbilirubin	-
24	38⁺²	2,060	Oligohydramnios	C-sec	-	-
25	39⁺³	2,260	-	C-sec	-	-
26	36⁺¹	1,720	Oligohydramnios	C-sec	-	-
27	37⁺⁶	2,490	PIH	C-sec	-	-

IUGR = intra-uterine growth retardation; GA = gestational age; BW = birth weight; RH = retinal hemorrhage; PIH = pregnancy-induced hypertension; VD = virginal delivery; C-sec = caesarean section; TTN = transient tachypnea of the newborn; OU = oculus uterque.

Figure 1.

Retinal hemorrhage found on a case 1 (#7) eye examination. Multiple retinal hemorrhage around the optic disc in both eyes (posterior and midperiphery). OD = oculus dexter; OS = oculus sinister.

Table 2.

Fundus findings in 3 cases of retinal hemorrhage

Case 1 (#7)	OD 4 quadrant posterior pole & midperiphery	OS 4 quadrant posterior pole & midperipheral
Case 2 (#11)	Superior & inferior to optic disc, inferior midperiphery	Parafoveal, temporal midperiphery
Case 3 (#21)	4 quadrant posterior pole & midperiphery	4 quadrant posterior pole & midperiphery

Table 3.

Comparison of underlying demographic factors for newborn’s retinal hemorrhages in intra-uterine growth retardation in fants

Retinal hemorrhage group (n = 3)	No retinal hemorrhage group (n = 24)
Avg. gestational age	37⁺⁶ weeks	36⁺⁵ weeks
Avg. birth weight	2,086.7 g ± 184.5	1,866.0 g ± 420.8
VD: C-Sec	2:1	5:19

Values are presented as mean ± SD unless otherwise indicated.

Avg. = average; VD = virginal delivery; C-Sec = caesarean section.

TOOLS

Similar articles