A Case of Choroidal Metastasis Caused by Lung Cancer

Jae Hyun Oh; Sang Jun Ko; Yun Sik Yang; Chang Wook Choi

doi:10.3341/jkos.2017.58.1.106

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Oh, Ko, Yang, and Choi: A Case of Choroidal Metastasis Caused by Lung Cancer

Original Article

J Korean Ophthalmol Soc 2015;58(1):106-112.

Published online: 30 August 2015

DOI: https://doi.org/10.3341/jkos.2017.58.1.106

A Case of Choroidal Metastasis Caused by Lung Cancer

Jae Hyun Oh, M.D^1,², Sang Jun Ko, M.D^1,², Yun Sik Yang, M.D^1,², Chang Wook Choi, M.D^1,^2,

¹Department of Ophthalmology, Wonkwang University School of Medicine, Iksan, Korea

²Institute of Wonkwang Medical Science, Wonkwang University, Iksan, Korea

￭ Address reprint requests to Chang Wook Choi, MD Department of Ophthalmology, Wonkwang University Hospital, #895 Muwang-ro, Iksan 54538, Korea Tel: 82-63-859-1370, Fax: 82-63-855-1801 E-mail: cuchoi77@hanmail.net

Received 6 October 201613 November 2016 Accepted 23 December 2016

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

To report a case of choroidal metastasis caused by lung cancer in a young female who had no history.

Case summary

A 31-year-old female presented with decreased vision for 1 week. Fundus examination revealed an orange col-ored choroidal tumor and serous retinal detachment at superotemporal area of the optic disc on the left eye. On chest X-ray, atypical pneumonia or hematogenous metastasis was shown. Additionally, mammography, chest-abdomen computed tomog-raphy, lumbar magnetic resonance imaging, and transbronchial lung biopsy were performed and the patient was finally diag-nosed with adenocarcinoma. The patient started systemic chemotherapy and visual acuity improved after 1 month. Tumor size and subretinal fluid also decreased. The tumor disappeared 2 months later and there was no recurrence.

Conclusions

There are only few cases in which choroidal metastasis was observed in a young female patient with no history who had decreased visual acuity and was later diagnosed with lung cancer. Authors report this case because a satisfactory re-sult was obtained from chemotherapy alone.

Keywords: Chemotherapy, Choroidal metastasis, Lung cancer

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Figure 1.

Fundus photography and optical coherence tomography (OCT) of Left eye. (A) Yellow- white choroidal mass was seen. (B) Serous retinal detachment was observed (yellow arrows). (C) OCT shows choroidal mass (dome shaped elevation of neuro-sensory retina and retinal pigmented epithelium). (D) OCT shows serous retinal detachment.

Figure 2.

Ultrasonography of left eye. Dome-shaped mass about 3 mm height was seen (yellow arrow).

Figure 3.

Fluorescein and Indocyanine green (ICG) angiography of Left eye. (A) Early phase of fluorescein angiography. (B) Latent phase of fluorescein angiography. Fluorescein angiography showing progressive hyperfluorescence in subsequent phases and capillary dilatation at the border of the lesion with pinpoint leakages. (C) Early phase of ICG showing blocked hypofluorescence. (D) Late phase of ICG showing hyperfluorescence at the border of the lesion.

Figure 4.

Chest computed tomography (CT) and magnetic resonance imaging (MRI) of spine. (A) Coronal view of chest CT shows peribronchial and perilymphatic nodules highly suggesting metastasis (yellow arrowheads). (B) MRI of spine shows metastatic os-teoclastic lesion (white arrows).

Figure 5.

Optical coherence tomography after chemotherapy. (A) 1 month after chemotherapy. Choroidal mass and subretinal fluid (SRF) were improved (B) 13 month after chemotherapy. Choroidal mass and SRF were disappeared.

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