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Lee, Lee, You, Cho, and Ahn: Analysis of Microorganisms and Antibiotics Susceptibility in Dacryocystitis
Original Article

Journal of the Korean Ophthalmological Society 2017; 58(9): 1017-1022.

Published online: 18 September 2017

DOI: https://doi.org/10.3341/jkos.2017.58.9.1017

Analysis of Microorganisms and Antibiotics Susceptibility in Dacryocystitis

Chang Hoon Lee, MD1, Tae Eun Lee, MD, PhD1, 2, 3, In Cheon You, MD, PhD1, 2, 3, Nam Chun Cho, MD, PhD1, 2, 3, Min Ahn, MD, PhD1, 2, 3

1Department of Ophthalmology, Chonbuk National University Medical School, Jeonju, Korea.

2Research Institute of Clinical Medicine, Chonbuk National University, Jeonju, Korea.

3Biomedical Research Institute, Chonbuk National University Hospital, Jeonju, Korea.

Address reprint requests to: Min Ahn, MD, PhD. Department of Ophthalmology, Chonbuk National University Hospital, #20 Geonji-ro Deokjin-gu, Jeonju 54907, Korea. Tel: 82-63-250-1960, Fax: 82-63-250-1960, ahnmin@jbnu.ac.kr

Received 29 September 2016       Revised 22 January 2017       Accepted 17 August 2017

©2017 The Korean Ophthalmological Society

The Korean Ophthalmological Society

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

This article analyzes the microorganisms and antibiotics susceptibility in dacryocystitis.

Methods

In this study, patients who were diagnosed with acute and chronic dacryocystitis with nasolacrimal duct obstruction were selected and underwent endoscopic endonasal dacryocystorhinostomy. Cultures were obtained from the lacrimal sac during operation from January 2008 to January 2016, and were used to analyze the microorganisms and antibiotics susceptibility.

Results

The 67 patients, 9 were diagnosed with acute dacryocystitis and 58 were diagnosed with chronic dacryocystitis. Among them, 64 cases showed bacterial growth (95.5%). The most frequently detected bacteria was Staphylococcus epidermidis (S. epidermidis) (33.8%), followed by Staphylococcus aureus (S. aureus) (25.4%) and Enterobacter aerogenes (18.3%). S. epidermidis had the most powerful resistance to ciprofloxacin compared to the other bacteria (58.3%, p = 0.02). Except for S. epidermidis and S. aureus, the other bacteria responded to ciprofloxacin and gentamycin.

Conclusions

As a causative microorganism of dacryocystitis, S. epidermidis is becoming more prominent, and it is thought that S. epidermidis may be resistant to quinolones (i.e., broad-spectrum antibiotics). This resistance might be increasing the percentage of present S. epidermidis when viewed as a causal pathogen in dacryocystitis.

Keywords: Antibiotics susceptibility, Dacryocystitis, Microorganism

Figures and Tables

Figure 1

Ciprofloxacin resistance difference between S.epidermidis and other bacteria: resistance differance between S.epidermidis and S.aureus is statistically significant. Between S.aureus and gram negative species, it has no resistance differance. *By Chi-square test. S. epidermidis = Staphylococcus epidermis; S.aureus = Staphylococcus aureus.

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Figure 2

Microorganism culture rate from 2008 to 2015. Before 2012 among the cultured bacteria, the proportion of S.epidermidis was small. But after 2012, proportion of the S.epidermidis has incresed significantly. S. epidermidis = Staphylococcus epidermis.

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Table 1

Isolated microorganism distribution from lacrimal sac with dacryocystitis

jkos-58-1017-i001

Values are presented as n (%).

Table 2

Antibiotics resistance of microoganism from lacrimal sac with dacryocystitis

jkos-58-1017-i002
Table 3

Review of literature of organisms cultured from dacryocystitis

jkos-58-1017-i003

Values are presented as n (%).

Notes

Conflicts of Interest The authors have no conflicts to disclose.

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