Journal List > J Korean Ophthalmol Soc > v.57(5) > 1010578

Kim, Koo, Ha, Lee, Lee, and Park: Effect of 0.05% Cyclosporine A on the Ocular Surface after Photorefractive Keratectomy

Abstract

Purpose

To evaluate the effect of 0.05% cyclosporine A on the ocular surface after photorefractive keratectomy (PRK).

Methods

This retrospective study included 50 patients who underwent PRK. Patients were divided into two groups: 25 patients in group I were treated with topical 0.05% cyclosporine A with conventional medication, and 25 patients in group II were treated with conventional medication. Visual acuity (VA), tear break-up time (BUT), fluorescein staining score (F-stain), Schirmer I test, and ocular surface disease index (OSDI) were evaluated before surgery and 2 weeks, 1 month, 2 months, and 3 months after surgery.

Results

F-stain was significantly lower in group I than in group II at 2 weeks and 1 month (p< 0.05). There was no significant difference in uncorrected VA, BUT, Schirmer I test, or OSDI between the groups. However, group I showed a more effective pattern in dry eye.

Conclusions

Combination treatment with 0.05% cyclosporine A was helpful for early ocular surface stability in patients with dry eye after PRK.

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Figure 1.
Comparison of uncorrected visual acuity between the groups over time. (A) Group I and group II show a significant difference compared to preoperative values during the follow-up period (compared with preoperative value by repeated measure analysis of variance [ANOVA]). (B) There was no statistically significant difference between the groups (compared by Mann-Whitney U-test). Group I = conventional treatment + 0.05% cyclosporine A; Group II = conventional treatment. ∗p < 0.05.
jkos-57-710f1.tif
Figure 2.
Comparison of tear break-up time between the groups over time. (A) Group I shows a significant difference at 2 weeks compared with preoperative value, and group II at 2 weeks and 1 month (p < 0.05, compared with preoperative value by repeated measure analysis of variance [ANOVA]). (B) There is no statistically significant difference between the groups during the follow-up period (compared by Student’s t-test). Group I = conventional treatment + 0.05% cyclosporine A; Group II = conventional treatment. ∗p < 0.05.
jkos-57-710f2.tif
Figure 3.
Comparison of fluorescein staining score between the groups over time. (A) Group I shows a significant difference at 2 weeks compared with preoperative value, and group II at 2 weeks and 3 months (p < 0.05, compared with preoperative value by repeated measure analysis of variance [ANOVA]). (B) There is a statistically significant difference between the groups at 2 weeks and 1 month (p < 0.05, compared by Student’s t-test). Group I = conventional treatment + 0.05% cyclosporine A; Group II = conventional treatment. ∗p < 0.05.
jkos-57-710f3.tif
Figure 4.
Comparison of Schirmer I test between the groups over time. (A) Group I and group II shows no significant difference during the follow-up period compared with preoperative values (compared with preoperative value by repeated measure analysis of variance [ANOVA]). (B) There is no statistically significant difference between the groups during the follow-up period (compared by Student’s t-test). Group I = conventional treatment + 0.05% cyclosporine A; Group II = conventional treatment.
jkos-57-710f4.tif
Figure 5.
Comparison of ocular surface disease index between the groups over time. (A) Group I and group II shows no significant difference during the follow-up period compared with preoperative value (compared with preoperative value by repeated measure analysis of variance [ANOVA]). (B) There is no statistically significant difference between the groups during the follow-up period (compared by Student’s t-test). Group = conventional treatment + 0.05% cyclosporine A; Group I = conventional treatment + 0.05% cyclosporine A; Group II = conventional treatment.
jkos-57-710f5.tif
Table 1.
Demographics of the study groups
  Group I Group II p-value
Number of eyes 25 25  
Patients (male:female) 10:15 8:17 0.556
Mean age (years) 25.4 ± 6.6 25.8 ± 5.3 0.523
Uncorrected visual acuity (log MAR) 1.06 ± 0.32 1.15 ± 0.20 0.693
Best corrected visual acuity (log MAR) 0 0 1.000
Spherical equivalent (diopter) -4.86 ± 2.27 -5.17 ± 2.45 0.352
Ablation depth (μm) 83.28 ± 30.70 87.33 ± 26.67 0.245
Ablation diameter (mm) 6.54 ± 0.30 6.45 ± 0.31 0.589
Tear BUT (second) 6.64 ± 2.62 6.56 ± 2.95 0.920
F-stain 0.64 ± 0.91 0.72 ± 1.21 0.792
Schirmer I test (mm) 11.93 ± 5.71 12.40 ± 10.67 0.832
OSDI 24.78 ± 12.80 23.74 ± 16.07 0.696

Values are presented as mean ± SD unless otherwise indicated. ‘Group I’ is ‘conventional treatment + 0.05 % cyclosporine A and ‘Group II’ is ‘conventional treatment’.

BUT = break-up time; F-stain = fluorescein staining score; OSDI = ocular surface disease index.

Chi-square test;

Mann-Whitney U-test;

Student’s t-test.

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