Journal List > J Korean Ophthalmol Soc > v.57(2) > 1010506

J Korean Ophthalmol Soc. 2016 Feb;57(2):264-275. Korean.
Published online February 16, 2016.  https://doi.org/10.3341/jkos.2016.57.2.264
©2016 The Korean Ophthalmological Society
Analysis of Macular Layer Thickness Measured Using Spectral Domain Optical Coherence Tomography in Korean Subjects
Chung Hwan Kim, MD,1 Sun Young Jin, MD,1 Young Hoon Lee, MD,1 and Young Suk Chang, MD1,2
1Department of Ophthalmology, Konyang University College of Medicine, Daejeon, Korea.
2Myunggok Medical Research Institute, Konyang University, Daejeon, Korea.

Address reprint requests to Young Suk Chang, MD. Department of Ophthalmology, Konyang University Hospital, #158 Gwanjeodong-ro, Seo-gu, Daejeon 35365, Korea. Tel: 82-42-600-9258, Fax: 82-42-600-9251, Email: happycys@kyuh.ac.kr
Received September 03, 2015; Revised October 10, 2015; Accepted December 21, 2015.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.


Abstract

Purpose

To analyze macular layer thickness using spectral domain optical coherence tomography (SD-OCT) in normal subjects.

Methods

One hundred normal eyes were enrolled in this study. Macular thickness was measured via enhanced depth imaging using Heidelberg Spectralis® OCT, using calipers within the program.

Results

Central subfield thickness was 11.35 ± 2.11 µm in the retinal nerve fiber layer, 13.33 ± 4.16 µm in the ganglion cell layer, 19.38 ± 3.20 µm in the inner plexiform layer, 18.23 ± 4.66 µm in the inner nuclear layer, 23.27± 6.83 µm in the outer plexiform layer, 91.97 ± 9.59 µm in the outer nuclear layer, 16.68 ± 1.83 µm in the retinal pigment epithelium layer, 179.82 ± 29.99 µm in the inner retinal layer, and 88.32 ± 2.81 µm in the photoreceptors layer. No significant differences were observed in the spherical equivalent according to age. Despite no significant differences being present, the macular central subfield thickness was thinner in women than in men.

Conclusions

In the present study, differences in macular layer thickness were found according to age and gender which should be considered when macular diseases are evaluated.

Keywords: Korean normal subjects; Macular layer thickness; Spectral domain optical coherence tomography

Figures


Figure 1
ETDRS subfields within standard 1-, 3-, and 6-mm diameter concentric circles at the right used for reporting retinal thickness (central circle: F, inner ring: SI+NI+II+TI, outer ring: SO+NO+IO+TO). ETDRS = Early Treatment of Diabetic Retinopathy Study; F = fovea; SI = superior inner; NI = nasal inner; II = inferior inner; TI = temporal inner; SO = superior outer; NO = nasal outer; IO = inferior outer; TO = temporal outer.
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Tables


Table 1
Demographics of patients
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Table 2
Macular subfield thicknesses at retinal nerve fiber layer
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Table 3
Macular subfield thicknesses at ganglion cell layer
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Table 4
Macular subfield thicknesses at inner plexiform layer
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Table 5
Macular subfield thicknesses at inner nuclear layer
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Table 6
Macular subfield thicknesses at outer plexiform layer
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Table 7
Macular subfield thicknesses at outer nuclear layer
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Table 8
Macular subfield thicknesses at retinal pigment epithelium layer
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Table 9
Macular subfield thicknesses at inner retinal layer
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Table 10
Macular subfield thicknesses at photoreceptors layer
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Notes

This work was supported by Konyang University Myunggok Research Fund of 2015.

References
1. Lee YJ. Analysis of factors associated with variability in measures obtained by spectral domain optical coherence tomography. J Korean Ophthalmol Soc 2012;53:639–646.
2. Ko TH, Fujimoto JG, Schuman JS, et al. Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular pathology. Ophthalmology 2005;112:1922.e1–1922.e15.
3. Chae MB, Kim JS. Foveal shape according to age and gender using spectral domain optical coherence tomography. J Korean Ophthalmol Soc 2014;55:1504–1510.
4. Nussenblatt RB, Kaufman SC, Palestine AG, et al. Macular thickening and visual acuity. Measurement in patients with cystoid macular edema. Ophthalmology 1987;94:1134–1139.
5. Ko BW, Shin YW, Lee JM, et al. Comparison of macular thickness measurements between fourier-domain and time-domain optical coherence tomography in normal eyes and eyes with macular diseases. J Korean Ophthalmol Soc 2009;50:1661–1668.
6. Song WK, Lee SC, Lee ES, et al. Macular thickness variations with sex, age, and axial length in healthy subjects: a spectral domain-optical coherence tomography study. Invest Ophthalmol Vis Sci 2010;51:3913–3918.
7. Zou H, Zhang X, Xu X, Yu S. Quantitative in vivo retinal thickness measurement in chinese healthy subjects with retinal thickness analyzer. Invest Ophthalmol Vis Sci 2006;47:341–347.
8. Kanai K, Abe T, Murayama K, Yoneya S. Retinal thickness and changes with age. Nippon Ganka Gakkai Zasshi 2002;106:162–165.
9. Neuville JM, Bronson-Castain K, Bearse MA Jr, et al. OCT reveals regional differences in macular thickness with age. Optom Vis Sci 2009;86:E810–E816.
10. Guedes V, Schuman JS, Hertzmark E, et al. Optical coherence tomography measurement of macular and nerve fiber layer thickness in normal and glaucomatous human eyes. Ophthalmology 2003;110:177–189.
11. Kang JH, Kim SA, Song WG, Yoon HS. Macular thickness changes with age in normal subjects measured by optical coherence tomography. J Korean Ophthalmol Soc 2004;45:592–598.
12. Kim SH, Choi KS, Lee SJ. Macular thickness changes with age and gender in emmetropia using spectral domain optical coherence tomography. J Korean Ophthalmol Soc 2011;52:299–307.
13. Wong AC, Chan CW, Hui SP. Relationship of gender, body mass index, and axial length with central retinal thickness using optical coherence tomography. Eye (Lond) 2005;19:292–297.
14. Duan XR, Liang YB, Friedman DS, et al. Normal macular thickness measurements using optical coherence tomography in healthy eyes of adult Chinese persons: the Handan Eye Study. Ophthalmology 2010;117:1585–1594.
15. Massin P, Erginay A, Haouchine B, et al. Retinal thickness in healthy and diabetic subjects measured using optical coherence tomography mapping software. Eur J Ophthalmol 2002;12:102–108.
16. Evans JR, Schwartz SD, McHugh JD, et al. Systemic risk factors for idiopathic macular holes: a case-control study. Eye (Lond) 1998;12(Pt 2):256–259.
17. Risk factors for idiopathic macular holes. The Eye Disease Case-Control Study Group. Am J Ophthalmol 1994;118:754–761.
18. Lim MC, Hoh ST, Foster PJ, et al. Use of optical coherence tomography to assess variations in macular retinal thickness in myopia. Invest Ophthalmol Vis Sci 2005;46:974–978.
19. Wakitani Y, Sasoh M, Sugimoto M, et al. Macular thickness measurements in healthy subjects with different axial lengths using optical coherence tomography. Retina 2003;23:177–182.