Journal List > J Korean Ophthalmol Soc > v.57(2) > 1010451

Jang, Lee, and Baek: Clinical Characteristics of Benign Eyelid Tumors

Abstract

Purpose

To report the relative frequency and clinical characteristics of patients with benign eyelid tumors.

Methods

A retrospective study of 192 consecutive patients admitted to Korea University Ansan Hospital with benign eyelid tumor between January 2009 and December 2014 was undertaken, and clinical records including age, sex, involved site, and pathology of tumors were reviewed retrospectively. All eyelid tumors were confirmed histopathologically.

Results

The sexual distribution revealed 87 males and 105 females with benign eyelid tumors. The mean age at diagnosis was 42.6 ± 19.2 years. Molluscum contagiosum (5.5 ± 3.5 years) and pilomatrixoma (14.0 ± 15.6 years) were generally found in younger individuals, while seborrheic keratosis (60.2 ± 15.8 years) and squamous cell papilloma (50.5 ± 13.4 years) occurred predominantly in elderly patients. Tumors were most common on the upper lid (63.0%). The four most frequent subtypes were melanocytic nevus (37.5%), epidermal cyst (8.3%), squamous cell papilloma (5.7%), and seborrheic keratosis (5.2%).

Conclusions

The most common histopathological diagnosis of benign eyelid tumors was melanocytic nevus. The results of this study provide epidemiological information that will be useful for diagnosis and therapy of such tumors.

REFERENCES

1). Welch RB, Duke JR. Lesions of the lids; a statistical note. Am J Ophthalmol. 1958; 45:415–26.
crossref
2). Allington HV, Allington JH. Eyelid tumors. Arch Dermatol. 1968; 97:50–65.
crossref
3). Lee HK, Hu CH, Kang SJ, Lee SY. Clinical analysis of lid tumors. J Korean Ophthalmol Soc. 1997; 38:1892–8.
4). Deprez M, Uffer S. Clinicopathological features of eyelid skin tumors. A retrospective study of 5504 cases and review of literature. Am J Dermatopathol. 2009; 31:256–62.
crossref
5). Hornblass A, Hanig CJ. Oculoplastic, Orbital and Reconstructive Surgery. Vol. 1. Baltimore: Williams & Wilkins;1988. p. 193–205.
crossref
6). O'Brien CS, Braley AE. Common tumors of the eyelids. J Am Med Assoc. 1936; 107:933–8.
7). Reese AB. Tumors of the Eye. 3rd ed.New York: Medical Dept., Harper & Row;1976. p. 54–6.
crossref
8). Bak SI, Lee SH, Bak BG. Benign tumors of the eye and its adnexa. J Korean Ophthalmol Soc. 1978; 19:333–9.
9). Lee TS, Lee JJ. Analysis of classification and incidence of eyelid and orbital tumors. J Korean Ophthalmol Soc. 1997; 38:1700–5.
10). Choi JH, Chi MJ, Baek SH. Clinical analysis of benign eyelid and conjunctival tumors. J Korean Ophthalmol Soc. 2003; 44:1268–77.
11). Al-Faky YH. Epidemiology of benign eyelid lesions in patients presenting to a teaching hospital. Saudi J Ophthalmol. 2012; 26:211–6.
crossref
12). Lee JC, Chyung EJ, Park SR. Clinical and histopathological observation on acquired melanocytic nevus (1975~ 1985). Korean J Dermatol. 1988; 26:874–8.
13). Older JJ. Tumors Eyelid. Diagnosis Clinical Treatment Surgical. 2nd ed.New York: Raven Press;2003. p. 47.
14). Lee GS, Ahn KJ, Kim JM, Lee ES. A histopathologic study of the seborrheic keratosis. Korean J Dermatol. 1992; 30:76–80.
15). Choi YH, Chung BS, Choi KC. A stastistical survey of cutaneous epithelial cysts. Korean J Dermatol. 1986; 24:61–6.
16). Orlando RG, Rogers GL, Bremer DL. Pilomatricoma in a pediatric hospital. Arch Ophthalmol. 1983; 101:1209–10.
crossref
17). Perez RC, Nicholson DH. Malherbe's calcifying epithelioma (pilomatrixoma) of the eyelid. Clinical features. Arch Ophthalmol. 1979; 97:314–5.
crossref
18). Smith RJ, Kuo IC, Reviglio VE. Multiple apocrine hidrocystomas of the eyelids. Orbit. 2012; 31:140–2.
crossref
19). Moehlenbech FW. Pilomatrixoma (calcifying epithelioma). Arch Dermatol. 1973; 108:532–4.
crossref
20). Kim KH, Chung WS. Classification and therapeutic effect of benign and malignant eyelid tumors. J Korean Ophthalmol Soc. 1997; 38:703–9.
21). Kersten RC, Ewing-Chow D, Kulwin DR, Gallon M. Accuracy of clinical diagnosis of cutaneous eyelid lesions. Ophthalmology. 1997; 104:479–84.
crossref

Figure 1.
Compound nevus. A compound nevus of the upper eyelid margin in a 48-year-old woman (black arrow).
jkos-57-174f1.tif
Figure 2.
Intradermal nevus. (A) A pigmented melanocytic nevus at the lower eyelid margin in a 34-year-old man (black arrow). (B) A nonpigmented melanocytic nevus of lower eyelid in a 69-year-old woman (black arrow).
jkos-57-174f2.tif
Figure 3.
Squamous papilloma. A Slightly elevated, pigmented mass located on the lower eyelid in a 52-year-old woman (black arrow).
jkos-57-174f3.tif
Figure 4.
Seborrheic keratosis. An elevated brown-colored mass located on the upper eyelid in a 47-year-old woman (black arrow).
jkos-57-174f4.tif
Figure 5.
Epidermal cyst. A smooth, soft, yellowish ruptured epidermal cyst located on the upper eyelid in a 27-year-old man (black arrow).
jkos-57-174f5.tif
Figure 6.
Dermoid cyst. A smooth, subcutaneous mass in the lateral aspect of the eyebrow in a 27-year-old woman (black arrow).
jkos-57-174f6.tif
Figure 7.
Pilomatrixoma. (A) A fairly well circumscribed mass located on the upper eyelid in a 3-year-old child (black arrow). (B) When he closed his eye, the lesion is well demarcated (black arrow).
jkos-57-174f7.tif
Table 1.
Sex and age distribution of benign eyelid tumors
Age (years) Number
Male Female Total (%)
0-9 9 6 15 (7.8)
10-19 9 2 11 (5.7)
20-29 9 11 20 (10.4)
30-39 14 20 34 (17.7)
40-49 18 25 43 (22.4)
50-59 13 15 28 (14.6)
60-69 11 15 26 (13.5)
70-79 3 10 13 (6.8)
80< 0 2 2 (1.0)
Total (%) 86 (44.8) 106 (55.2) 192 (100)
Table 2.
Benign eyelid tumors
Type of tumor Number (%) Age (years) Sex (female/male) Location (upper/lower)
Melanocytic nevi 72 (37.5)
  Intradermal nevus 54 (28.1) 42.4 ± 13.6 35/19 28/26
  Compound nevus 18 (9.4) 33.3 ± 16.3 9/9 14/4
Tumors of the epidermis
  Epidermal cyst 16 (8.3) 42.4 ± 19.2 6/10 11/5
  Squamous cell papilloma 11 (5.7) 50.5 ± 13.4 6/5 5/6
  Seborrheic keratosis 10 (5.2) 60.2 ± 15.8 7/3 5/5
  Dermoid cyst 7 (3.6) 17.6 ± 12.3 3/4 7/0
  Inverted follicular keratosis 1 (0.5) 38.0 1/0 0/1
Tumors of eccrine and apocrine gland origin
  Syringoma 2 (1.0) 50.5 ± 0.7 1/1/ 1/1
  Hidrocystoma 1 (0.5) 64 0/1 0/1
Hair follicle tumors
  Trichoepithelioma 3 (1.6) 38.0 ± 5.0 1/2 3/0
  Pilomatrixoma 2 (1.0) 14.0 ± 15.6 1/1 2/0
Chronic inflammation 49 (16.8) 45.6 ± 23.1 25/24 31/18
Vascular tumors 7 (3.6)
  Capillary hemangioma 4 (2.1) 33.5 ± 16.6 0/4 2/2
  Cavernous hemangioma 2 (1.0) 28.5 ± 23.3 1/1 2/0
  Others 1 (0.5) 39.0 1/0 1/0
Tumors of neural crest origin
  Neurofibroma 3 (1.6) 67.3 ± 8.4 3/0 2/1
Miscellaneous
  Xanthelasma 2 (1.0) 55.0 ± 7.1 0/2 2/0
  Molluscum contagiosum 2 (1.0) 5.5 ± 3.5 2/0 0/2
  Lipoma 1 (0.5) 74.0 1/0 1/0
  Xanthogranuloma 1 (0.5) 2.0 1/0 1/0
Others 2 (1.0) 1/1 1/1
Total (%) 192 (100) 104/86 119/73

Values are presented as mean ± SD unless otherwise indicated.

TOOLS
Similar articles