A Case of Eyelid Sebaceoma Mimicking Chalazion

Hak Jun Lee; Soo Kee Min; Min Joung Lee

doi:10.3341/jkos.2016.57.8.1303

Journal List > J Korean Ophthalmol Soc > v.57(8) > 1010376

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Lee, Min, and Lee: A Case of Eyelid Sebaceoma Mimicking Chalazion

Case Report

J Korean Ophthalmol Soc 2016;57(8):1303-1306.

Published online: 25 September 2016

DOI: https://doi.org/10.3341/jkos.2016.57.8.1303

A Case of Eyelid Sebaceoma Mimicking Chalazion

Hak Jun Lee, MD¹, Soo Kee Min, MD², Min Joung Lee, MD¹

¹Department of Ophthalmology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea

²Department of Pathology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea

Address reprint requests to Min Joung Lee, MD Department of Ophthalmology, Hallym University Sacred Heart Hospital, #22 Gwanpyeong-ro 170beon-gil, Dongan-gu, Anyang 14068, Korea Tel: 82-31-380-3834, Fax: 82-31-380-3834 E-mail: minjounglee77@gmail.com

Received 19 May 2016 Revised 7 June 2016 Accepted 15 July 2016

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

To report a rare case of sebaceoma misdiagnosed as chalazion.

Case summary

A 42-year-old female presented with a visible mass in her right lower eyelid. An elevated, hard mass was located at the margin of the right lower eyelid, and she had a history of incision and curettage under the clinical impression of chalazion. On eversion of the lower eyelid, the tarsal portion of the mass was visible as a white-yellowish lesion. The mass was excised under local anesthesia. A sebaceoma was diagnosed based on histopathological examinations. Immunohistochemical studies showed positive staining results for mutator L homologue 1 (MLH1), mutator S homologue 2 (MSH2), and mutator S homologue 6 (MSH6), and she had no past medical history or family history of internal malignancy, suggesting a low possibility of Muir-Torre syndrome.

Conclusions

Eyelid sebaceoma should be considered as a differential diagnosis for refractory chalazion.

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Keywords: Chalazion, Sebaceoma, Sebaceous epithelioma

References

1. Troy JL, Ackerman AB. Sebaceoma. A distinctive benign neoplasm of adnexal epithelium differentiating toward sebaceous cells. Am J Dermatopathol. 1984; 6:7–13.

2. Lazar AJ, Lyle S, Calonje E. Sebaceous neoplasia and Torre-Muir syndrome. Curr Diagn Pathol. 2007; 13:301–19.

3. Cohen PR, Kohn SR, Kurzrock R. Association of sebaceous gland tumors and internal malignancy: the Muir-Torre syndrome. Am J Med. 1991; 90:606–13.

4. John AM, Schwartz RA. Muir-Torre syndrome (MTS): An update and approach to diagnosis and management. J Am Acad Dermatol. 2016; 74:558–66.

5. Al-Khashnam H, Burezq H, Al-Aradi I, et al. Unusual malignant transformation of recurrent sebaceoma. A case report. Clin Med Oncol. 2008; 2:389–92.

6. Shalin SC, Lyle S, Calonje E, Lazar AJ. Sebaceous neoplasia and the Muir-Torre syndrome: important connections with clinical implications. Histopathology. 2010; 56:133–47.

7. Yonekawa Y, Jakobiec FA, Zakka FR, Fay A. Sebaceoma of the eyelid. Ophthalmology. 2012; 119:2645.e1–4.

8. Mittal R, Tripathy D. Sebaceoma of the eyelid: a rare entity. Can J Ophthalmol. 2014; 49:e78–80.

9. Kwon JS, Choi JG, Song GY, Park IK. A case of sebaceous abdominal on the lower palpebral conjunctiva. J Korean Ophthalmol Soc. 2003; 44:508–10.

10. Cesinaro AM, Ubiali A, Sighinolfi P, et al. Mismatch repair abdominal expression and microsatellite instability in skin lesions with sebaceous differentiation: a study in different clinical subgroups with and without extracutaneous cancer. Am J Dermatopathol. 2007; 29:351–8.

11. Kruse R, Ruzicka T. DNA mismatch repair and the significance of a sebaceous skin tumor for visceral cancer prevention. Trends Mol Med. 2004; 10:136–41.

12. Ko CJ. Muir-Torre syndrome: facts and controversies. Clin Dermatol. 2010; 28:324–9.

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Figure 1.

Anterior segment photographs of the mass at initial presentation. (A) An eyelid mass located on temporal margin of the right lower eyelid. The mass was elevated and the border was not clearly delineated at skin side. There was no loss of eyelashes or destruction of eyelid margin. (B) On eversion of the lower eyelid, the tarsal portion of the mass was visible as a subconjunctival white-yellowish lesion.

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Figure 2.

Histopathological findings of the mass. (A) The tumor is composed of variably sized lobules and cells (H&E, magnification ×100). (B) The majority of tumor cells are undifferentiated basaloid cells with small islands of cells with abundant foamy to va-cuolated cytoplasm (H&E, magnification ×400).

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Figure 3.

The immunohistochemical staining results of the mass. Tumor cells were (A) positive for mutator L homologue 1 (MLH1), (B) weak positive for mutator S homologue 2 (MSH2), (C) and positive for mutator S homologue 6 (MSH6) (magnification ×200).

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