Change in Subfoveal Choroidal Thickness after Patterned Panretinal Photocoagulation in Patients with Diabetic Retinopathy

Hye Min Jeon; Sue Hey Chae; Soh-Eun Ahn; Sang Won Kim; Hee Seong Yoon

doi:10.3341/jkos.2016.57.8.1216

Journal List > J Korean Ophthalmol Soc > v.57(8) > 1010360

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Jeon, Chae, Ahn, Kim, and Yoon: Change in Subfoveal Choroidal Thickness after Patterned Panretinal Photocoagulation in Patients with Diabetic Retinopathy

Original Article

J Korean Ophthalmol Soc 2016;57(8):1216-1221.

Published online: 25 September 2016

DOI: https://doi.org/10.3341/jkos.2016.57.8.1216

Change in Subfoveal Choroidal Thickness after Patterned Panretinal Photocoagulation in Patients with Diabetic Retinopathy

Hye Min Jeon, MD, Sue Hey Chae, MD, Soh-Eun Ahn, MD, Sang Won Kim, MD, Hee Seong Yoon, MD, PhD

Sungmo Eye Hospital, Busan, Korea

Address reprint requests to Hee Seong Yoon, MD, PhD Sungmo Eye Hospital, #409 Haeun-daero, Haeundae-gu, Busan 48064, Korea Tel: 82-51-743-0775, Fax: 82-51-743-0776 E-mail: heesyoon@dreamwiz.com

Received 14 April 2016 Revised 23 May 2016 Accepted 14 July 2016

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

To evaluate changes in subfoveal choroidal thickness (SFCT) after patterned panretinal photocoagulation (PRP) using pattern scan laser (PASCAL) in patients with diabetic retinopathy.

Methods

This study included 39 patients (50 eyes) treated with patterned PRP using PASCAL and who were followed for at least 3 months. Patients were classified into 2 groups according to severity: severe non-proliferative diabetic retinopathy and proliferative diabetic retinopathy. SFCT was measured by enhanced depth imaging of spectraldomain optical coherence tomography. The change in SFCT was analyzed at 1 and 3 months after PRP.

Results

SFCT was 270.42 ± 61.44 μ m before PRP, 264.52 ± 60.78 μ m at 1 month, and 255.74 ± 56.89 μ m at 3 months after PRP. Significant change of SFCT was found at 3 months after PRP. Central macular thickness was 275.56 ± 50.61 μ m before PRP and increased to 295.18 ± 52.80 μ m and 293.10 ± 57.24 μ m at 1 and 3 months posttreatment, respectively. There were no significant differences between groups in SFCT at baseline or in the amount of change in SFCT after PRP.

Conclusions

SFCT significantly decreased after patterned PRP using PASCAL.

Keywords: Diabetic retinopathy, Panretinal photocoagulation, Pattern scan laser, Spectral-domain optical coherence tomography (SD-OCT), Subfoveal choroidal thickness

References

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Figure 1.

Consecutive changes of the mean subfoveal choroidal thickness (SFCT) and central macular thickness (CMT) after patterned panretinal photocoagulation. Data are expressed as the mean ± standard error of mean. * p < 0.05 by repeated measures analysis of variance (ANOVA).

Figure 2.

Scatter plots for correlation between subfoveal choroidal thickness (SFCT) and central macular thickness (CMT). (A) At 1 month after patterned panretinal photocoagulation (PRP), there was no significant correlation between SFCT and CMT (r = −0.133, p = 0.201). (B) At 3 months after patterned PRP, there was no significant correlation between SFCT and CMT (r = −0.184, p = 0.245). Compared by Pearson's correlation analysis. r = coefficient of correlation.

Table 1.

Demographics of patients

Characteristics	Values
Eyes (n)	50
Patients (n)	39
Laterality (OD:OS)	27:23
Age (years)	57.4 ± 8.4
Sex (M:F)	29:21
Visual acuity (log MAR)	0.20 ± 0.28
SFCT (μ m)	270.42 ± 61.44
CMT (μ m)	275.56 ± 50.61
Severity (n)
Severe NPDR	30
PDR	20

Values are presented as mean ± SD unless otherwise indicated. SFCT = subfoveal choroidal thickness; CMT = central macular thickness; NPDR = non-proliferative diabetic retinopathy; PDR = proliferative diabetic retinopathy.

Table 2.

Comparison of baseline and amount of change after patterned panretinal photocoagulation according to disease severity

	Severe NPDR	PDR	p-value^*
SFCT (μ m)	290.05 ± 52.92	257.33 ± 64.03	0.064
Δ^† 1 month	–6.33 ± 20.67	–5.25 ± 27.85	0.593
Δ 3 months	–8.54 ± 20.60	–13.36 ± 24.18	0.762
CMT (μ m)	277.53 ± 47.46	272.60 ± 56.15	0.739
Δ 1 month	20.47 ± 23.30	18.35 ± 57.83	0.308
Δ 3 months	20.79 ± 34.64	7.64 ± 42.70	0.290

Values are presented as mean ± SD unless otherwise indicated.

NPDR = non-proliferative diabetic retinopathy; PDR = proliferative diabetic retinopathy; SFCT = subfoveal choroidal thickness; CMT = central macular thickness.

^* Compared by student t-test

^† Amount of change.

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