Journal List > J Korean Ophthalmol Soc > v.57(8) > 1010360

Jeon, Chae, Ahn, Kim, and Yoon: Change in Subfoveal Choroidal Thickness after Patterned Panretinal Photocoagulation in Patients with Diabetic Retinopathy

Abstract

Purpose

To evaluate changes in subfoveal choroidal thickness (SFCT) after patterned panretinal photocoagulation (PRP) using pattern scan laser (PASCAL) in patients with diabetic retinopathy.

Methods

This study included 39 patients (50 eyes) treated with patterned PRP using PASCAL and who were followed for at least 3 months. Patients were classified into 2 groups according to severity: severe non-proliferative diabetic retinopathy and proliferative diabetic retinopathy. SFCT was measured by enhanced depth imaging of spectraldomain optical coherence tomography. The change in SFCT was analyzed at 1 and 3 months after PRP.

Results

SFCT was 270.42 ± 61.44 μ m before PRP, 264.52 ± 60.78 μ m at 1 month, and 255.74 ± 56.89 μ m at 3 months after PRP. Significant change of SFCT was found at 3 months after PRP. Central macular thickness was 275.56 ± 50.61 μ m before PRP and increased to 295.18 ± 52.80 μ m and 293.10 ± 57.24 μ m at 1 and 3 months posttreatment, respectively. There were no significant differences between groups in SFCT at baseline or in the amount of change in SFCT after PRP.

Conclusions

SFCT significantly decreased after patterned PRP using PASCAL.

References

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Figure 1.
Consecutive changes of the mean subfoveal choroidal thickness (SFCT) and central macular thickness (CMT) after patterned panretinal photocoagulation. Data are expressed as the mean ± standard error of mean. * p < 0.05 by repeated measures analysis of variance (ANOVA).
jkos-57-1216f1.tif
Figure 2.
Scatter plots for correlation between subfoveal choroidal thickness (SFCT) and central macular thickness (CMT). (A) At 1 month after patterned panretinal photocoagulation (PRP), there was no significant correlation between SFCT and CMT (r = −0.133, p = 0.201). (B) At 3 months after patterned PRP, there was no significant correlation between SFCT and CMT (r = −0.184, p = 0.245). Compared by Pearson's correlation analysis. r = coefficient of correlation.
jkos-57-1216f2.tif
Table 1.
Demographics of patients
Characteristics Values
Eyes (n) 50
Patients (n) 39
Laterality (OD:OS) 27:23
Age (years) 57.4 ± 8.4
Sex (M:F) 29:21
Visual acuity (log MAR) 0.20 ± 0.28
SFCT (μ m) 270.42 ± 61.44
CMT (μ m) 275.56 ± 50.61
Severity (n)  
 Severe NPDR 30
 PDR 20

Values are presented as mean ± SD unless otherwise indicated. SFCT = subfoveal choroidal thickness; CMT = central macular thickness; NPDR = non-proliferative diabetic retinopathy; PDR = proliferative diabetic retinopathy.

Table 2.
Comparison of baseline and amount of change after patterned panretinal photocoagulation according to disease severity
  Severe NPDR PDR p-value*
SFCT (μ m) 290.05 ± 52.92 257.33 ± 64.03 0.064
 Δ 1 month –6.33 ± 20.67 –5.25 ± 27.85 0.593
 Δ 3 months –8.54 ± 20.60 –13.36 ± 24.18 0.762
CMT (μ m) 277.53 ± 47.46 272.60 ± 56.15 0.739
 Δ 1 month 20.47 ± 23.30 18.35 ± 57.83 0.308
 Δ 3 months 20.79 ± 34.64 7.64 ± 42.70 0.290

Values are presented as mean ± SD unless otherwise indicated.

NPDR = non-proliferative diabetic retinopathy; PDR = proliferative diabetic retinopathy; SFCT = subfoveal choroidal thickness; CMT = central macular thickness.

* Compared by student t-test

Amount of change.

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