Measurement of Ophthalmic-arterial Blood-flow Velocity Using Transcranial Doppler Ultrasonography in Patients with Central Serous Chorioretinopathy

Tae Young Gil; Ji Sun Moon; Seong Joo Shin

doi:10.3341/jkos.2016.57.8.1210

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Gil, Moon, and Shin: Measurement of Ophthalmic-arterial Blood-flow Velocity Using Transcranial Doppler Ultrasonography in Patients with Central Serous Chorioretinopathy

Original Article

J Korean Ophthalmol Soc 2016;57(8):1210-1215.

Published online: 25 September 2016

DOI: https://doi.org/10.3341/jkos.2016.57.8.1210

Measurement of Ophthalmic-arterial Blood-flow Velocity Using Transcranial Doppler Ultrasonography in Patients with Central Serous Chorioretinopathy

Tae Young Gil, MD, Ji Sun Moon, MD, Seong Joo Shin, MD

Department of Ophthalmology, Sahmyook Medical Center, Seoul, Korea

Address reprint requests to Seong Joo Shin, MD Department of Ophthalmology, Sahmyook Medical Center, #82 Mangu-ro, Dongdaemun-gu, Seoul 02500, Korea Tel: 82-2-2210-3554, Fax: 82-2-2212-2673 E-mail: ymedi@hanmail.net

Received 21 April 2016 Revised 16 June 2016 Accepted 23 July 2016

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

To measure and compare the ocular blood-flow velocity of ophthalmic artery in patients with central serous chorioretinopathy (CSC); affected eyes, asymptomatic fellow eyes, and CSC resolved eyes using transcranial Doppler ultrasonography.

Methods

A total of 31 patients (age 20–52 years) with CSC were evaluated using power motion mode Doppler 150 digital transcranial Doppler ultrasonography. The peak systolic velocity (PSV), peak diastolic velocity (PDV), and resistance index (RI) were measured in the ophthalmic artery of both affected and asymptomatic fellow eyes. After 2 months, 23 patients with resolved serous retinal detachment underwent repeated measurement of the above hemodynamic indices.

Results

The PSV and PDV of the ophthalmic artery were 30.05 ± 5.34 cm/sec and 14.07 ± 2.90 cm/sec in affected eyes and 33.03 ± 2.00 cm/sec and 17.17 ± 2.76 cm/sec in asymptomatic fellow eyes, respectively. Both indices were significantly lower in affected eyes (p = 0.004, p < 0.001, respectively). The RI was 0.52 ± 0.08 in affected eyes and 0.43 ± 0.04 in fellow eyes, a significant difference (p < 0.001). After 2 months, in 23 eyes with resolved CSC, the PSV and PDV were 32.94 ± 6.24 cm/sec and 15.54 ± 2.88 cm/sec, respectively. Both indices were significantly higher than at baseline (p = 0.031, p = 0.045, respectively). However, RI was 0.48 ± 0.04 and was not significantly different (p = 0.073).

Conclusions

The CSC-affected eyes showed lower ocular blood-flow velocity and higher RI than the asymptomatic fellow eyes. The ocular blood-flow velocity was increased as CSC was resolved. These findings provide insights into the ophthalmic arterial vascular factors related to the pathogenesis of CSC.

Keywords: Central serous chorioretinopathy, Ophthalmic artery, Transcranial Doppler ultrasonography

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Figure 1.

Difference of ophthalmic artery Doppler variables between affected eye and control eye. (A) peak systolic velocity (PSV), (B) peak diastolic velocity (PDV), (C) RI. Note that 3 indices are significantly different (paired t-test). RI = resistive index ([PSV-PDV]/PSV). * p < 0.05.

Figure 2.

Difference of ophthalmic artery Doppler variables of affected eyes between in 1st visit and 2 month follow up (f/u). (A) peak systolic velocity (PSV), (B) peak diastolic velocity (PDV), (C) RI. Note that 2 indices are significantly different (W ilcoxon signed rank test). RI = resistive index ([PSV-PDV]/PSV). * p < 0.05.

Figure 3.

Images obtained from a patient with central serous chorioretinopathy. Doppler spectra in the ophthalmic artery of a healthy control eye (A) and an affected eye (B). P.I. = pulsatility index.

Table 1.

Ophthalmic artery Doppler variables of affected eyes and healthy control eyes

	Affected eyes	Control eyes	p-value^*
PSV (cm/sec)	30.05 ± 5.34	33.03 ± 2.00	0.004
PDV (cm/sec)	14.07 ± 2.90	17.17 ± 2.76	<0.001
RI	0.52 ± 0.08	0.43 ± 0.04	<0.001

Values are presented as mean ± SD unless otherwise indicated.

PSV = peak systolic velocity; PDV = peak diastolic velocity; RI = resistive index ([PSV-PDV]/PSV).

^* Paired t-test.

Table 2.

Ophthalmic artery Doppler variables of affected eyes in 1st visit and 2 month follow up

	1st visit	2 month follow up	p-value^*
PSV (cm/sec)	30.32 ± 5.52	32.94 ± 6.24	0.031
PDV (cm/sec)	14.32 ± 3.06	15.54 ± 2.88	0.045
RI	0.52 ± 0.09	0.48 ± 0.04	0.073

Values are presented as mean ± SD unless otherwise indicated.

PSV = peak systolic velocity; PDV = peak diastolic velocity; RI = resistance index ([PSV-PDV]/PSV).

^* Wilcoxon signed rank test.

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