Measuring Blood Viscosity in Normal Tension Glaucoma Patients

You Ra Kim; Ka Young Moon; Nam Chun Cho; Eui Young Kweon; Dong Wook Lee

doi:10.7469/JKOS.2015.56.05.753

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Kim, Moon, Cho, Kweon, and Lee: Measuring Blood Viscosity in Normal Tension Glaucoma Patients

Original Article

J Korean Ophthalmol Soc 2015;56(5):753-758.

Published online: 7 September 2015

DOI: https://doi.org/10.7469/JKOS.2015.56.05.753

Measuring Blood Viscosity in Normal Tension Glaucoma Patients

You Ra Kim, MD¹, Ka Young Moon, MD¹, Nam Chun Cho, MD^1,², Eui Young Kweon, MD^1,², Dong Wook Lee, MD, PhD^1,²

¹Department of Ophthalmology, Chonbuk National University Medical School, Jeonju, Korea

²Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Korea

￭ Address reprint requests to Dong Wook Lee, MD, PhD Department of Ophthalmology, Chonbuk National University Hospital, #20 Geonji-ro, Deokjin-gu, Jeonju 561-712, Korea Tel: 82-63-250-1965, Fax: 82-63-250-1960 E-mail: ldw@jbnu.ac.kr

Received 27 June 20144 November 2014 Accepted 19 April 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

초록

Purpose:

Non-intraocular pressure (IOP) factors such as vascular factors have been identified as contributing to normal tension glaucoma. However, there is not an established range of haemorheological factors considered normal, nor are there stand-ardized tests. In this study, we investigated differences in blood viscosity and haemorheological parameters between patients with normal tension glaucoma (NTG) and normal controls using a new instrument called the BVD-RO1 (BIO-VISCO. Inc., Jeonju, Korea).

Methods:

Twenty patients with NTG and 20 age-matched normal controls were included in the study. Haemorheological parameters of the venous blood samples, including blood viscosity at the shear rates of 300 (high shear rate) and 1 (low shear rate) s⁻¹ were measured using an automated scanning capillary tube viscometer.

Results:

More hematocrit concentration was detected in the NTG group than in the control group ( p < 0.05). Furthermore, higher blood viscosities at the high ( p < 0.01) and low ( p < 0.01) shear rates were found in the NTG group.

Conclusions:

The NTG patients differed in blood viscosity with the control group. This may signify the importance of hemodynamic factors in the pathogenesis of NTG.

Keywords: Blood viscosity, Normal tension glaucoma

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Figure 1.

Whole blood viscosity at shear rate of 1 s^-1 and 300 s^-1. (A) Low-shear blood viscosity in NTG and control group. (B) High-shear blood viscosity in NTG and control group. NTG = normal tension glaucoma; CNT = Control. ^* p < 0.05 statistically significant.

Table 1.

Baseline clinical characterisctics and recent medication

	Normal tension glaucoma	Control	p-value^*
Age (years)	61.2 ± 10.39	58.3 ± 7.86	0.33
Male (n, %)	9 (45) ± 0.51	9 (45) ± 0.51	1.00
Height (cm)	163.7 ± 8.25	163.4 ± 8.48	0.93
Weight (kg)	63.3 ± 8.55	66.7 ± 12.65	0.33
Hypertension (n, %)	7 (35) ± 0.49	8 (40) ± 0.50	0.75
Diabetes (n, %)	4 (20) ± 0.41	4 (20) ± 0.41	1.00
Dyslipidemia (n, %)	3 (15) ± 0.37	4 (20) ± 0.41	0.69
Smoking (n, %)	5 (25) ± 0.44	5 (25) ± 0.44	1.00

Values are presented as mean ± SD.

^* Independent sample t-test.

Table 2.

Baseline laboratory findings of normal tension glaucoma group and control group

	Normal tension glaucoma	Control	p-value^*
WBC (×10³/mm³)	7.2 ± 1.43	7.8 ± 0.84	0.08
Hematocrit (%)	42.8 ± 3.75	40.2 ± 3.54	0.04^†
Hemoglobin (g/dL)	14.7 ± 1.10	14.1 ± 1.04	0.10
HbA1c (%)	6.0 ± 1.40	6.2 ± 1.06	0.55
Platelet (×10³/mm³)	224.7 ± 54.36	216 ± 25.46	0.52
Triglyceride (mg/dL)	127.4 ± 76.41	111.3 ± 34.62	0.40
Total cholesterol (mg/dL)	171.5 ± 25.21	167.8 ± 31.22	0.69
LDL cholesterol (mg/dL)	94.3 ± 22.47	92.7 ± 20.10	0.81
HDL cholesterol (mg/dL)	43 ±13.80	41.8 ± 10.32	0.76

Values are presented as mean ± SD.

WBC = white blood cell; HbA1c = glycated hemoglobin; LDL = low-density lipoprotein; HDL = high-denstiy lipoprotein.

^* Independent sample t-test;

^† p < 0.05 statistically significant.

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