Comparison of Central Corneal Thickness and Anterior Chamber Depth Measured Using Three Different Devices

Se Hun Han; Ho Sik Hwang; Min Chul Shin; Kyung Eun Han

doi:10.7469/JKOS.2015.56.05.694

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Han, Hwang, Shin, and Han: Comparison of Central Corneal Thickness and Anterior Chamber Depth Measured Using Three Different Devices

Original Article

J Korean Ophthalmol Soc 2015;56(5):694-701.

Published online: 7 September 2015

DOI: https://doi.org/10.7469/JKOS.2015.56.05.694

Comparison of Central Corneal Thickness and Anterior Chamber Depth Measured Using Three Different Devices

Se Hun Han, MD, Ho Sik Hwang, MD, Min Chul Shin, MD, PhD, Kyung Eun Han, MD

Department of Ophthalmology, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, Korea

￭ Address reprint requests to Kyung Eun Han, MD Department of Ophthalmology, Hallym University Chuncheon Sacred Heart Hospital, #77 Sakju-ro, Chuncheon 200-704, Korea Tel: 82-33-240-5176, Fax: 82-33-255-6244 E-mail: hkeoph@gmail.com

Received 14 November 201424 February 2015 Accepted 9 April 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

초록

Purpose:

To compare measurements of central corneal thickness (CCT) and anterior chamber depth (ACD) obtained using Galilei™, Pentacam^® (Oculus, Wetzlar, Germany) and Lenstar^® (Haag-Streit, Koeniz, Switzerland) and analyze the measurement agreements.

Methods:

CCT and ACD were measured using Galilei™, Pentacam^® and Lenstar^® in 47 eyes of 25 healthy subjects. The measurements were compared among the 3 devices.

Results:

The average CCT measurements using Galilei™, Pentacam^® and Lenstar^® were 552.6 ± 29.41 μ m, 543.9 ± 30.50 μ m and 537.5 ± 30.26 μ m, respectively. The measurements significantly correlated with each other (r > 0.9, p < 0.001), but were statistically significantly different ( p < 0.001). The average ACD measurements using Galilei™, Pentacam^® and Lenstar^® were 3.23 ± 0.360 mm, 3.22 ± 0.403 mm and 3.19 ± 0.367 mm, respectively. The measurements significantly correlated with each other (r > 0.9, p < 0.001), but were statistically significantly different ( p = 0.034). The CCT 95% limits of agreement (LoA) between Galilei™ and Pentacam^®, Pentacam^® and Lenstar^® and Lenstar^® and Galilei™ were 31.95 μ m, 44.76 μ m and 46.57 μ m, respectively and 95% ACD LoA were 0.46 mm, 0.32 mm and 0.28 mm, respectively.

Conclusions:

CCT and ACD measured using the 3 devices were highly correlated with each other but the measurements were statistically different. Therefore, the measurements were not interchangeable and these differences should be considered in clinical use.

Keywords: Anterior chamber depth, Central corneal thickness, Galilei™, Lenstar^®, Pentacam^®

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Figure 1.

Scatter plots of central corneal thickness (μ m) between (A) Galilei™ and Pentacam®, (B) Pentacam® and Lenstar®, (C) Lenstar® and Galilei™.

Figure 2.

Bland-Altman plots of CCT (μ m) between (A) Galilei™ and Pentacam®, (B) Pentacam® and Lenstar®, (C) Lenstar® and Galilei™. CCT = central corneal thickness.

Figure 3.

Scatter plots of anterior chamber depth (mm) between (A) Galilei™ and Pentacam®, (B) Pentacam® and Lenstar®,(C) Lenstar® and Galilei™.

Figure 4.

Bland-Altman plots of ACD (mm) between (A) Galilei™ and Pentacam®, (B) Pentacam® and Lenstar®, (C) Lenstar® and Galilei™. ACD = anterior chamber depth.

Table 1.

The central corneal thickness (μ m) and anterior chamber depth (mm) measured by Galilei™, Pentacam® and Lenstar®

		Galilei™	Pentacam®	Lenstar®	Difference
		Galilei™	Pentacam®	Lenstar®	Galilei™- Pentacam®	Pentacam®- Lenstar®	Lenstar®- Galilei™
CCT (μ m)	Mean ± SD	552.6 ± 29.42	543.9 ± 30.50	537.5 ± 30.26	8.68 ± 8.15	6.47 ± 11.42	-15.15 ± 11.88
	Min, max	474, 608	466, 603	476, 593	-8, 32	-15, 30	-44, 6
	p-value^*	-	-	-	<0.001	0.001	<0.001
ACD (mm)	Mean ± SD	3.23 ± 0.360	3.22 ± 0.403	3.19 ± 0.367	0.01 ± 0.117	0.03 ±0.082	-0.04 ± 0.072
	Min, max	2.41, 3.80	2.38, 4.12	2.37, 3.76	-0.39, 0.32	-0.11, 0.39	-0.30, 0.10
	p-value^*	-	-	-	1.000	0.134	0.003

CCT = central corneal thickness; ACD = anterior chamber depth.

^* Repeated measures analysis of variance with Bonferroni post hoc analysis.

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