Ah Ran Cho; Na Hee Kang; Roo Min Jun

doi:10.3341/jkos.2015.56.1.6

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Cho, Kang, and Jun: Relationship between Dry Eye Parameters and Anterior Corneal Higher‐ Order Aberrations Measured by Two Different Instruments

Original Article

J Korean Ophthalmol Soc 2015;56(1):6-12.

Published online: 6 September 2015

DOI: https://doi.org/10.3341/jkos.2015.56.1.6

Relationship between Dry Eye Parameters and Anterior Corneal Higher‐ Order Aberrations Measured by Two Different Instruments

Ah Ran Cho, MD, Na Hee Kang, MD, Roo Min Jun, MD, PhD

Department of Ophthalmology, Ewha Womans University School of Medicine, Seoul, Korea

Address reprint requests to Roo Min Jun, MD, PhD, Department of Ophthalmology, Ewha Womans University Medical Center, #1071 Anyangcheon-ro, Yangcheon-gu, Seoul 158-710, Korea, Tel: 82-2-2650-5154, Fax: 82-2-2654-4334 E-mail: jrmoph@ewha.ac.kr

Received 18 October 20132 April 2014 Accepted 24 November 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

To compare the corneal first surface higher-order aberrations (HOAs) of normal subjects and patients with dry eye using KR-1W^® (Topcon Corp., Tokyo, Japan) and Pentacam^® HR (Oculus Inc., Dutenhofen, Germany). We analyzed the relationship between the aberrations and the diagnostic parameters of dry eye.

Methods

We evaluated anterior corneal HOAs in 71 normal eyes and 71 dry eyes using KR-1W^® and Pentacam^®. Dry eye patients were examined for fluorescein staining, tear break-up time (TBUT), and Schirmer I test. Ocular Surface Disease Index (OSDI) was used for assessment of subjective symptoms in dry eye patients.

Results

HOAs measured by both instruments were greater in the dry eye group than in the control group, although HOAs using KR-1W^® only achieved statistical significance. The anterior corneal HOAs measured by the 2 instruments were significantly correlated with superficial punctate keratitis. Moreover, TBUT and the Shirmer I test negatively correlated, and OSDI positively correlated, with anterior corneal HOAs.

Conclusions

The HOAs in patients with dry eye were significantly different from controls and tended to increase with disease severity. KR-1W^® might be more useful than Pentacam^® to detect tear film instabilities.

Keywords: Anterior corneal higher-order aberrations, Dry eye, HOAs, KR-1W^®, Pentacam^®

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Figure 1.

Comparison of the HOAs of dry eye group to the control group using KR-1W® (A) and Pentacam® (B). HOAs = high-er-order aberrations; 2˚ Astig. = secondary astigmatism; SA = spherical aberration. ^* p < 0.05 based on independent sample t-test between the dry eyes and control group.

Figure 2.

Comparison of HOAs between KR-1W® and Pentacam® in normal (A) and dry eye groups (B). HOAs = higher-order aberrations; 2˚ Astig. = secondary astigmatism; SA = spherical aberration. ^* p < 0.05 based on independent sample t-test between the dry eyes and control group.

Figure 3.

Correlation coefficients between 4 parameters and higher-order aberrations (HOAs) measured by KR-1W® (A) and Pentacam® (B) in the dry eye group. T_HOAs = total HOAs; 3rd_HOAs = third HOAs; 4th_HOAs = fourth HOAs; 2˚ Astig. = secondary astigmatism; SA = spherical aberration; TBUT = tear break-up time; OSDI = ocular surface disease index. ^* p < 0.05 based on Spearman’s correlation coefficient.

Table 1.

Demographics of normal and dry eye groups

	Control group (n = 71)	Dry-eye group (n = 71)	p-value^∗
Age (years, range) Sex (M/F)	41.1 ± 15.4 (21-77)17/40	45.5 ± 12.7 (23.76) 14/45	0.091 0.144^†
SE (diopter)	-1.7 ± 2.7	-1.6 ± 2.4	0.167
Mean K (diopter)	43.7 ± 1.5	44.1 ± 1.6	0.651

Values are presented as mean ± SD unless otherwise indicated. SE = spherical equivalent; K = keratometry.

^∗ p-value based on independent sample t-test

^† p-value based on chisquare test.

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