Abstract
Purpose
To compare the lamina cribrosa thickness in fellow eyes of patients with unilateral retinal vein occlusion (RVO) with the normal control eyes and the type of RVO.
Methods
This study included 40 patients with unilateral RVO and 45 normal control subjects. We compared the lamina cribrosa thickness between the RVO eyes and the fellow eyes, the fellow eyes and the normal control eyes and the type of RVO eyes. We measured central lamina thickness using enhanced depth imaging spectral-domain optical coherence tomography.
Results
In patients with unilateral RVO, central lamina cribrosa thickness was not significantly different between the RVO eyes (211.33 μ m) and the fellow eyes (204.13 μ m; p = 0.202). However, central lamina cribrosa thickness in the fellow eyes was sig-nificantly reduced compared with the normal control eyes (217.76 μ m; p = 0.046). Central lamina cribrosa thickness in the fellow eyes according to the type of RVO was not statistically significantly different ( p = 0.672).
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Figure 1.
Cross-sectional image of the optic nerve head by Spectralis® OCT in the EDI mode. The central lamina cribrosa thickness was measured between the anterior and posterior border of the highly reflective region that was visible beneath the center of optic disc cup (arrowheads). OCT = optical coherence tomography; EDI = enhanced depth imaging.
![jkos-56-1736f1.tif](/upload/SynapseXML/0035jkos/thumb/jkos-56-1736f1.gif)
Table 1.
Patients demographics and clin nical information
RVO fellow eyes group (n = 40) | Normal eyes group (n = 35) | p-value | |
---|---|---|---|
Sex (male, n) | 15 (37.5) | 21 (45.7) | 0.474* |
Age (years) | 58.58 ± 9.03 | 57.57 ± 10.94 | 0.665† |
OD:OS | 22:18 | 17:18 | 0.581* |
Systemic disease | |||
Hypertension (n) | 18 (45.0) | 13 (37.1) | 0.493* |
Diabetes mellitus (n) | 4 (10.0) | 7 (20.0) | 0.225* |
Spherical equivalent (diopter) | 0.11 ± 1.73 | -0.29 ± 1.48 | 0.295† |
Cup-disc ratio | 0.53 ± 0.20 | 0.53 ± 0.11 | 0.858† |
Intraocular pressure (mm Hg) | 15.28 ± 16.46 | 15.11 ± 3.60 | 0.955† |
Table 2.
Reproducibility of the central lamina cribrosa thickness
ICC (95% confidence interval) | p-value | |
---|---|---|
RVO eyes group | 0.884 (0.778-0.939) | 0.000 |
RVO fellow eyes group | 0.819 (0.652-0.906) | 0.000 |
Normal eyes group | 0.873 (0.748-0.936) | 0.000 |
Table 3.
Comparison of the central lamina cribrosa thickness and cup-disc ratio between RVO fellow eyes group and RVO eyes group
RVO fellow eyes group | RVO eyes group | p-value | |
---|---|---|---|
Central lamina cribrosa thickness (μ m) | 204.13 ± 32.26 | 211.33 ± 26.25 | 0.202* |
Cup-disc ratio | 0.53 ± 0.20 | 0.50 ± 0.24 | 0.146* |
Table 4.
Comparison of the central lamina cribrosa thickness between RVO fellow eyes group and normal eyes group
RVO fellow eyes group | Normal eyes group | p-value | |
---|---|---|---|
Central lamina cribrosa thickness (μ m) | 204.13 ± 32.26 | 217.76 ± 23.97 | 0.046* |
Table 5.
Comparison of the fellow eyes between ON-RVO and AV-RVO
ON-RVO (n = 16) | AV-RVO (n = 24) | p-value | |
---|---|---|---|
Sex (male, n) | 6 (37.5) | 9 (37.5) | 1.000* |
Age (years) | 54.06 ± 9.56 | 61.58 ± 7.41 | 0.007* |
OD:OS | 9:7 | 13:11 | 0.924* |
Systemic disease | |||
Hypertension (n) | 8 (50.0) | 10 (41.7) | 0.672* |
Diabetes mellitus (n) | 3 (18.8) | 1 (4.2) | 0.452* |
Spherical equivalent (diopter) | -0.40 ± 2.09 | 0.45 ± 1.39 | 0.132† |
Cup-disc ratio | 0.58 ± 0.21 | 0.50 ± 0.19 | 0.185† |
Intraocular pressure (mm Hg) | 12.31 ± 3.36 | 17.25 ± 21.03 | 0.539* |
Central lamina cribrosa thickness (μ m) | 210.47 ± 28.19 | 199.52 ± 34.83 | 0.672* |