Lamina Cribrosa Thickness in the Fellow Eyes of Patients with Unilateral Retinal Vein Occlusion

Yong Il Kim; Tea Yoon Lee; Kyoo Won Lee; Jin Seon Kim

doi:10.3341/jkos.2015.56.11.1736

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Kim, Lee, Lee, and Kim: Lamina Cribrosa Thickness in the Fellow Eyes of Patients with Unilateral Retinal Vein Occlusion

Original Article

J Korean Ophthalmol Soc 2015;56(11):1736-1741.

Published online: 29 August 2015

DOI: https://doi.org/10.3341/jkos.2015.56.11.1736

Lamina Cribrosa Thickness in the Fellow Eyes of Patients with Unilateral Retinal Vein Occlusion

Yong Il Kim, M.D, Tea Yoon Lee, M.D, Kyoo Won Lee, M.D, PhD, Jin Seon Kim, M.D

Cheil Eye Hospital, Daegu, Korea

Address reprint requests to Jin Seon Kim, MD Cheil Eye Hospital, #1 Ayang-ro, Dong-gu, Daegu 41196, Korea Tel: 82-53-959-1751, Fax: 82-53-959-1758 E-mail: ppjinsun25@hanmail.net

‗ This study was presented as a poster at the 113th Annual Meeting of the Korean Ophthalmological Society 2015.

Received 29 May 20155 August 2015 Accepted 1 October 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

To compare the lamina cribrosa thickness in fellow eyes of patients with unilateral retinal vein occlusion (RVO) with the normal control eyes and the type of RVO.

Methods

This study included 40 patients with unilateral RVO and 45 normal control subjects. We compared the lamina cribrosa thickness between the RVO eyes and the fellow eyes, the fellow eyes and the normal control eyes and the type of RVO eyes. We measured central lamina thickness using enhanced depth imaging spectral-domain optical coherence tomography.

Results

In patients with unilateral RVO, central lamina cribrosa thickness was not significantly different between the RVO eyes (211.33 μ m) and the fellow eyes (204.13 μ m; p = 0.202). However, central lamina cribrosa thickness in the fellow eyes was sig-nificantly reduced compared with the normal control eyes (217.76 μ m; p = 0.046). Central lamina cribrosa thickness in the fellow eyes according to the type of RVO was not statistically significantly different ( p = 0.672).

Conclusions

This study showed that the central lamina cribrosa thickness in the fellow eyes of patients with unilateral RVO was thinner than in normal patients. Therefore, the lamina cribrosa thickness may be associated with RVO as well as glaucoma.

Keywords: Arteriovenous crossing retinal vein occlusion, Glaucoma, Lamina cribrosa thickness, Optic nerve-sited retinal vein occlusion, Retinal vein occlusion

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Figure 1.

Cross-sectional image of the optic nerve head by Spectralis® OCT in the EDI mode. The central lamina cribrosa thickness was measured between the anterior and posterior border of the highly reflective region that was visible beneath the center of optic disc cup (arrowheads). OCT = optical coherence tomography; EDI = enhanced depth imaging.

Table 1.

Patients demographics and clin nical information

	RVO fellow eyes group (n = 40)	Normal eyes group (n = 35)	p-value
Sex (male, n)	15 (37.5)	21 (45.7)	0.474^*
Age (years)	58.58 ± 9.03	57.57 ± 10.94	0.665^†
OD:OS	22:18	17:18	0.581^*
Systemic disease
Hypertension (n)	18 (45.0)	13 (37.1)	0.493^*
Diabetes mellitus (n)	4 (10.0)	7 (20.0)	0.225^*
Spherical equivalent (diopter)	0.11 ± 1.73	-0.29 ± 1.48	0.295^†
Cup-disc ratio	0.53 ± 0.20	0.53 ± 0.11	0.858^†
Intraocular pressure (mm Hg)	15.28 ± 16.46	15.11 ± 3.60	0.955^†

Values are presented as mean ± SD unless otherwise indicated.

RVO = retinal vein occlusion.

^* Mann-Whitney U-test

^† Student’s t-test.

Table 2.

Reproducibility of the central lamina cribrosa thickness

	ICC (95% confidence interval)	p-value
RVO eyes group	0.884 (0.778-0.939)	0.000
RVO fellow eyes group	0.819 (0.652-0.906)	0.000
Normal eyes group	0.873 (0.748-0.936)	0.000

RVO = retinal vein occlusion; ICC = intraclass correlation coefficient.

Table 3.

Comparison of the central lamina cribrosa thickness and cup-disc ratio between RVO fellow eyes group and RVO eyes group

	RVO fellow eyes group	RVO eyes group	p-value
Central lamina cribrosa thickness (μ m)	204.13 ± 32.26	211.33 ± 26.25	0.202^*
Cup-disc ratio	0.53 ± 0.20	0.50 ± 0.24	0.146^*

Values are presented as mean ± SD unless otherwise indicated.

RVO = retinal vein occlusion.

^* Paired t-test.

Table 4.

Comparison of the central lamina cribrosa thickness between RVO fellow eyes group and normal eyes group

	RVO fellow eyes group	Normal eyes group	p-value
Central lamina cribrosa thickness (μ m)	204.13 ± 32.26	217.76 ± 23.97	0.046^*

Values are presented as mean ± SD unless otherwise indicated.

RVO = retinal vein occlusion.

^* Compared by Student’s t-test, p < 0.05.

Table 5.

Comparison of the fellow eyes between ON-RVO and AV-RVO

	ON-RVO (n = 16)	AV-RVO (n = 24)	p-value
Sex (male, n)	6 (37.5)	9 (37.5)	1.000^*
Age (years)	54.06 ± 9.56	61.58 ± 7.41	0.007^*
OD:OS	9:7	13:11	0.924^*
Systemic disease
Hypertension (n)	8 (50.0)	10 (41.7)	0.672^*
Diabetes mellitus (n)	3 (18.8)	1 (4.2)	0.452^*
Spherical equivalent (diopter)	-0.40 ± 2.09	0.45 ± 1.39	0.132^†
Cup-disc ratio	0.58 ± 0.21	0.50 ± 0.19	0.185^†
Intraocular pressure (mm Hg)	12.31 ± 3.36	17.25 ± 21.03	0.539^*
Central lamina cribrosa thickness (μ m)	210.47 ± 28.19	199.52 ± 34.83	0.672^*

Values are presented as mean ± SD or n (%).

RVO = retinal vein occlusion; ON-RVO = optic cup sited and optic nerve sited RVO; AV-RVO = arteriovenous crossing RVO.

^* Mann-Whitney U-test

^† Student’s t-test.

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