Abstract
Purpose
To report a case of melanocytoma originating from the iris observed for the first time in Korea.
Case summary
A 53-year-old female with an unexpected iris mass was referred to our clinic. A round, 2.5 mm x 3.5 mm-sized iris mass was found on slit lamp examination in the 12 o'clock area of the patient's left eye. The mass was densely pigmented and had a smooth surface. Gonioscopy showed the mass had reached the peripheral cornea frontward and the lens backward. An excisional biopsy was performed for diagnosis. After the operation, a gonioscopic examination showed an intact ciliary body behind the surgical margin of the iris. A melancytoma of the iris was observed on subsequent histopathological examination. The patient has remained symptom-free with no iris mass recurrence since the operation.
References
1. Zimmerman LE, Garrón LK. Melanocytoma of the optic disc. International Ophthalmology Clinics. 1962; 2:431–40.
2. Al-Hinai A, Edelstein C, Burnier MN Jr. Unusual case of melanocytoma. Can J Ophthalmol. 2004; 39:461–3.
3. Choi SW, Seo SG, Her J. A case of melanocytoma of the ciliary body. J Korean Ophthalmol Soc. 2009; 50:946–50.
4. Lee CS, Kim DK, Lee SC. A case of ciliary body melanocytoma pre-senting as a painful iris mass. Korean J Ophthalmol. 2010; 24:44–6.
5. Zimmerman LE. MELANOCYTES, MELANOCYTIC NEVI, AND MELANOCYTOMAS. Invest Ophthalmol. 1965; 4:11–41.
6. Shields CL, Kancherla S, Patel J, et al. Clinical survey of 3680 iris tumors based on patient age at presentation. Ophthalmology. 2012; 119:407–14.
7. Singh AD, Turell ME, Topham AK. Uveal melanoma: trends in in-cidence, treatment, and survival. Ophthalmology. 2011; 118:1881–5.
8. Esmaili DD, Mukai S, Jakobiec FA, et al. Ocular melanocytoma. Int Ophthalmol Clin. 2009; 49:165–75.
9. Shields JA, Demirci H, Mashayekhi A, Shields CL. Melanocytoma of optic disc in 115 cases: the 2004 Samuel Johnson Memorial Lecture, part 1. Ophthalmology. 2004; 111:1739–46.
10. Lee CS, Bae JH, Jeon IH, et al. Melanocytoma of the optic disk in the Korean population. Retina. 2010; 30:1714–20.
11. LoRusso FJ, Boniuk M, Font RL. Melanocytoma (magnocellular nevus) of the ciliary body: report of 10 cases and review of the literature. Ophthalmology. 2000; 107:795–800.
12. Shields JA, Shields CL, Eagle RC Jr. Melanocytoma (hyperpi-gmented magnocellular nevus) of the uveal tract: the 34th G. Victor Simpson lecture. Retina. 2007; 27:730–9.
13. Howard GM, Forrest AW. Incidence and location of melano-cytomas. Arch Ophthalmol. 1967; 77:61–6.
14. Demirci H, Mashayekhi A, Shields CL, et al. Iris melanocytoma: clinical features and natural course in 47 cases. Am J Ophthalmol. 2005; 139:468–75.
15. Cialdini AP, Sahel JA, Jalkh AE, et al. Malignant transformation of an iris melanocytoma. A case report. Graefes Arch Clin Exp Ophthalmol. 1989; 227:348–54.