A Case of Primary Signet Ring Cell Carcinoma of the Lower Eyelid

Seon Ae Shin; Sang Duck Kim; Ki Jung Yun

doi:10.3341/jkos.2014.55.4.611

Journal List > J Korean Ophthalmol Soc > v.55(4) > 1009950

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Shin, Kim, and Yun: A Case of Primary Signet Ring Cell Carcinoma of the Lower Eyelid

Original Article

J Korean Ophthalmol Soc 2014;55(4):611-615.

Published online: 7 September 2014

DOI: https://doi.org/10.3341/jkos.2014.55.4.611

A Case of Primary Signet Ring Cell Carcinoma of the Lower Eyelid

Seon Ae Shin, MD¹, Sang Duck Kim, MD, PhD¹, Ki Jung Yun, MD, PhD²

¹Department of Ophthalmology, Wonkwang University School of Medicine, Institute of Wonkwang Medical Science, Iksan, Korea

²Department of Pathology, Wonkwang University School of Medicine, Institute of Wonkwang Medical Science, Iksan, Korea

Address reprint requests to Sang Duck Kim, MD, PhD Department of Ophthalmology, Wonkwang University Hospital, #895 Muwang-ro, Iksan 570-711, Korea, Tel: 82-63-859-1370, Fax: 82-63-855-1801 E-mail: sangduck@wonkwang.ac.kr

Received 18 October 20134 November 2013 Accepted 4 March 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

To report a rare case of a painless mass on the lower lid, histologically diagnosed as primary signet ring cell carcinoma of the eyelid.

Case summary

A 74-year-old male presented with a painless mass on the right lower lid which had developed seven months prior to presentation. Incisional biopsy of the mass and attached lower lid skin was performed, revealing signet ring cell carcinoma. A systemic evaluation, including whole body positron emission tomography-computed tomography (PET-CT), chest CT, abdomen and pelvis CT, gastrointestinal endoscopy, and colonoscopy, revealed no other abnormal lesions. Therefore, the eyelid lesion was considered primary signet ring cell carcinoma of the skin and was treated with radiotherapy of 6600 cGy in 33 fractions over 7 weeks.

Conclusions

Herein, the authors report a rare case of primary signet ring cell carcinoma of the eyelid with no evidence of tumor recurrence or metastasis for 5 years after radiotherapy.

Keywords: Eyelid, Primary signet ring cell carcinoma

References

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Figure 1.

Clinical photograph of the painless mass (black arrow) of the right lower eyelid.

Figure 2.

Coronal (A) and axial (B) images of orbital computed tomography scan showing a mass in the right inferolateral orbit and diffuse soft tissue thickening with well enhancement in the right lacrimal fossa and preseptal area.

Figure 3.

(A, B) Histopathology reveals the tumor cells have ec-centric nuclei and some of the tumor cells show signet ring-like appearance (black arrow) in the fibrosclerotic background (A: H&E, ×400) and in the skeletal muscle fibers (B: H&E, ×200).(C) The tumor cells show positive staining for cytokeratin (×200).

Figure 4.

Orbital magnetic resonance imaging (MRI) showing no evidence of recurrence 5 years after radiotherapy. Post contrast T1-weighted axial (A) and coronal (B) views.

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