Journal List > J Korean Ophthalmol Soc > v.55(3) > 1009904

Park, Jung, Cho, Paik, and Yang: Clinicopathological Characteristics of Malignant Eyelid Tumor in Korea

Abstract

Purpose

To determine the clinical characteristics of patients with malignant eyelid tumors in Korea.

Methods

We performed a retrospective review of the medical records of 73 patients with malignant eyelid tumors who were histologically diagnosed at Seoul St. Mary’s hospital from April 2004 to September, 2012 and followed for 6 months or longer.

Results

Of 73 cases, 41 (56.2%) were diagnosed as basal cell carcinoma, 17 (23.3%) as squamous cell carcinoma, 11 (15.1%) as sebaceous gland carcinoma, 3 (4.1%) as malignant melanoma, and 1 (1.4%) as basosquamous cell carcinoma. The mean age at diagnosis was 68.4 ± 11.5 years. Tumors developed more commonly on the lower lid (54.8%). Most cases were treated by complete resection of tumors and eyelid reconstruction (95.9%). The prognosis of patients with basal cell carcinoma and squamous cell carcinoma was good, while that of the other tumors was relatively poor.

Conclusions

The most common diagnosis was basal cell carcinoma (56.2%). Recurrence after complete surgical excision and reconstruction was uncommon.

References

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Figure 1.
Histological type of 41 patients with eyelid basal cell carcinoma.
jkos-55-348f1.tif
Figure 2.
Age distribution of malignant eyelid tumors treated at Seoul St. Mary’s Hospital.
jkos-55-348f2.tif
Table 1.
Histopathological classification of malignant eyelid tumors treated at Seoul St. Mary’s Hospital
Histopathological classification No. of case (%)
Basal cell carcinoma 41 (56.2)
Squamous cell carcinoma 17 (23.3)
Sebaceous carcinoma 11 (15.1)
Malignant melanoma 3 (4.1)
Basosquamous cell carcinoma 1 (1.4)
Table 2.
Histologic findings of squamous cell carcinoma
Histologic finding No. of cases (%)
Cell differentiation  
  Well diffentiated 8 (47.1%)
  Moderately differentiated 9 (52.9%)
  Poorly differentiated 0
Invasion  
  Perineural invasion 0
  Muscular invasion 1
  Vascular invasion 0
Table 3.
Sex distribution of malignant eyelid tumors treated at Seoul St. Mary’s Hospital
  Men Women
Basal cell carcinoma 10 31
Squamous cell carcinoma 5 12
Sebaceous carcinoma 4 7
Malignant melanoma 0 3
Basosquamouscell carcinoma 0 1
Total 19 (26.02%) 54 (73.9%)
Table 4.
Location of malignant eyelid tumors treated at Seoul St. Mary’s Hospital
  Lower lid (%) Upper lid (%) Medial canthus (%)
Basal cell carcinoma 33 (80.5) 4 (9.8) 4 (9.8)
Squamous cell carcinoma 3 (17.6) 14 (82.4)  
Sebaceous carcinoma 3 (27.3) 8 (72.7)  
Malignant melanoma 1 (33.3) 1 (33.3) 1 (33.3)
Total 40 (54.8) 27 (36.9) 5 (6.8)
Table 5.
Primary Treatment modalities of malignant eyelid tumors treated at Seoul St. Mary’s Hospital
  Basal cell cancer Squamous cell cancer Sebaceous cancer Malignant melanoma Baso-squamous cell cancer Total (%)
Simple Excision   1   2   3 (4.1)
Excision and direct closure 16 3 2   1 22 (30.1)
Excision & reconstruction            
  Cutler-Beard   3 4     7 (9.6)
  Tarsoconjunctival 1 4       5 (6.8)
  Modified Hughes 9 3 2 1   15 (20.5)
  Tenzel’s flap 10 1 3     14 (19.1)
  Others 4         4 (5.5)
Exenteration 1 2       3 (4.1)
Table 6.
Frequency malignant eyelid tumors reported in different studies
  Basal cell carcinoma (%) Squamous cell carcinoma (%) Sebaceous carcinoma (%) Malignant melanoma (%)
Korea8-10 35.1 21.6 25.2 12.6
Korea (this study) 56.2 23.3 15.1 4.1
Japan5 39.5 21.8 27.0 7.8
Hong Kong6 75 5.6 11.1  
Taiwan4 65.1 12.6 7.9 1.9
India13 48.2 13.7 31.2 3.5
USA14,25 90.8 8.6 3.2 0.6
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