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Kim and Oh: Effects of Topical Tranilast on Corneal Haze with the Pentacam® after Photorefractive Keratectomy
Original Article

J Korean Ophthalmol Soc 2014;55(9):1277-1283.

Published online: 2 September 2014

DOI: https://doi.org/10.3341/jkos.2014.55.9.1277

Effects of Topical Tranilast on Corneal Haze with the Pentacam® after Photorefractive Keratectomy

Sung In Kim, MD, Tae Hoon Oh, MD

Department of Ophthalmology, Saevit Eye Hospital, Goyang, Korea

Address reprint requests to Tae Hoon Oh, MD, Department of Ophthalmology, Saevit Eye Hospital, #1065 Jungang-ro, Ilsandong-gu, Goyang 410-817, Korea, Tel: 82-31-900-7700, Fax: 82-31-900-7777, E-mail: 76drhoon@hanmail.net

Received 7 February 2014       Revised 5 May 2014       Accepted 1 August 2014

Copyright © 2014 The Korean Ophthalmological Society

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

To evaluate the inhibitory effect of tranilast on formation of corneal haze using the Pentacam® after photorefractive keratectomy (PRK).

Methods

A prospective, randomized, paired eye study was performed. A total of 60 eyes from 30 patients were enrolled in the present study. Eyes were categorized as myopic eyes <-5 D and ≥-5 D. Patients undergoing PRK were randomized to receive tranilast in one eye and no medication in the contralateral eye. Three months postoperatively, corneal haze was measured with the Pentacam® and compared between the 2 groups.

Results

Statistical differences were not found in preoperative data in the tranilast or control groups (all p > 0.05). There was a strong decreasing density trend from the apex to the 3 mm radius in both groups (p < 0.05). However, postoperative corneal haze in the tranilast group was similar to the control group (p > 0.05).

Conclusions

The use of tranilast after PRK did not inhibit corneal opacity. Additionally, Pentacam® can provide a useful objective measure of corneal haze.

Keywords: Corneal haze, Pentacam®, PRK, Tranilast

References

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Figure 1.
Scheimpflug image and slit-lamp photograph of a cornea after PRK.
jkos-55-1277f1.tif
Figure 2.
Correlation of corneal haze with distance from the apex for myopic eyes <- 5 D after photorefractive keratectomy (PRK) in tranilast (p < 0.05, r = −0.64).
jkos-55-1277f2.tif
Figure 3.
Correlation of corneal haze with distance from the apex for myopic eyes <- 5 D after photorefractive keratectomy (PRK) in control (p < 0.05, r = −0.66).
jkos-55-1277f3.tif
Figure 4.
Correlation of corneal haze with distance from the apex for myopic eyes ≥-5 D after photorefractive keratectomy (PRK) in tranilast (p < 0.05, r = −0.72).
jkos-55-1277f4.tif
Figure 5.
Correlation of corneal haze with distance from the apex for myopic eyes ≥-5 D after photorefractive keratectomy (PRK) in control (p < 0.05, r = −0.69).
jkos-55-1277f5.tif
Table 1.
Preoperative data of myopic eyes <-5 D
Group
 p-value
Tranilast Control
Age (years) 26.63 ± 5.54
Sex (M/F) 15 (7/8)
CCT (μm) 524.63 ± 23.51 527.25 ± 24.31 0.31
Sphere (diopter) −3.26 ± 0.94 −3.25 ± 0.82 0.96
Cylinder (diopter) −0.66 ± 0.46 −0.60 ± 0.42 0.51

Values are presented as mean ± SD.

CCT = central corneal thickness.

Table 2.
Postoperative data of myopic eyes <-5 D
Group
 p-value
Tranilast Control
UCVA (log MAR) 0.03 ± 0.07 0.04 ± 0.06 0.74
BCVA (log MAR) 0.00 ± 0.00 0.00 ± 0.00 1.00
MRSE (diopter) −0.18 ± 0.31 −0.19 ± 0.29 0.91
CCT (μm) 463.38 ± 30.00 465.56 ± 30.67 0.50

Values are presented as mean ± SD.

UCVA = uncorrected visual acuity; BCVA = best corrected visual acuity; MRSE = manifest refraction spherical equivalent; CCT = central corneal thickness.

Table 3.
Mean maximum density values measured with the Pentacam® for myopic eyes <-5 D
Distance from apex Tranilast Control p-value
0 mm 29.01 ± 2.82 29.50 ± 3.13 0.46
1 mm 27.94 ± 3.10 28.14 ± 2.94 0.69
2 mm 26.29 ± 2.75 26.20 ± 2.14 0.83
3 mm 22.78 ± 2.62 23.07 ± 2.33 0.39

Values are presented as mean ± SD.

Table 4.
Preoperative data of myopic eyes ≥-5 D
Group
 p-value
Tranilast Control
Age (years) 22.14 ± 8.47
Sex (M/F) 15 (7/8)
CCT (μm) 540.93 ± 22.43 543.71 ± 19.57 0.31
Sphere (diopter) −6.02 ± 0.21 −5.74 ± 0.24 0.26
Cylinder (diopter) −1.62 ± 0.56 −1.52 ± 0.68 0.46

Values are presented as mean ± SD.

CCT = central corneal thickness.

Table 5.
Postoperative data of myopic eyes ≥-5 D
Group
 p-value
Tranilast Control
UCVA (log MAR) 0.05 ± 0.09 0.04 ± 0.08 0.75
BCVA (log MAR) 0.00 ± 0.00 0.00 ± 0.00 1.00
MRSE (diopter) −0.21 ± 0.27 −0.23 ± 0.32 0.90
CCT 427.86 ± 21.10 432.07 ± 22.20 0.15

Values are presented as mean ± SD.

UCVA = uncorrected visual acuity; BCVA = best corrected visual acuity; MRSE = manifest refraction spherical equivalent; CCT = central corneal thickness.

Table 6.
Mean maximum density values measured with the Pentacam® for myopic eyes ≥-5 D
Distance from apex Tranilast Control p-value
0 mm 29.16 ± 2.74 29.03 ± 2.00 0.85
1 mm 27.19 ± 4.17 27.39 ± 2.17 0.83
2 mm 25.75 ± 3.41 26.13 ± 2.55 0.75
3 mm 23.36 ± 1.64 23.06 ± 2.05 0.59

Values are presented as mean ± SD.

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