Journal List > J Korean Ophthalmol Soc > v.54(5) > 1009679

Hye, Jin, Tae, Hyun, and Hyo: Clinical Features of Adie’s Tonic Pupil: A Retrospective and Cross-Sectional Study

Abstract

Purpose

To report the clinical features of Adie’s tonic pupil.

Methods

The medical records of 22 patients who had been diagnosed with Adie’s tonic pupil from February 1998 to February 2009, were retrospectively reviewed. On March 2010, a cross-sectional examination was performed in 16 pa-tients (19 eyes) who underwent a follow-up of more than 1 year. Measurements included pupil size in room light, bright light and in darkness; near point of accommodation; presence of segmental iris palsy; light-near dissociation; denervation su-persensitivity; corneal sensitivity; and deep tendon reflex (DTR).

Results

Among the patients studied, 16 were women in Adie’s tonic pupils. Only 3 of patients had bilateral involvement. The mean age of onset was 38.3 years. The mean size of Adie’s tonic pupils was 2.3 mm larger than the fellow eyes. Segmental iris palsy was detected in 93.8% of the patients. Denervation supersensitivity was observed in all patients. Light-near dissociation was present in 88.2% and over 90% of the patients had decreased DTR in the biceps, triceps, knee and ankle jerk.

Conclusions

This cross-sectional study showed Adie’s tonic pupil tended to become miotic and recover accommodation power over the years.

References

1. Thompson HS. Adie's syndrome: some new observations. Trans Am Ophthalmol Soc. 1977; 75:587–626.
2. Loewenfeld IE, Thompson HS. The tonic pupil: a re-evaluation. Am J Ophthalmol. 1967; 63:46–87.
crossref
3. Kaufman PL, Alm A. Adler's physiology of the eye. 10th ed. St. Louis:: Mosby;2003. p. 719–20.
4. Jonathan D, Neil R, Miller MD, Nancy J. Walsh and Hoyt’s Clinical Neuro-Ophthalmology, 6th ed. Philadelphia: Lippincott Williams & Wilkins;v. 1:2005. p. 761–4.
5. Oh TW, Kim JD, Kim BH, Cha OJ. A case of tonic pupil. J Korean Ophthalmol Soc. 1968; 9:25–8.
6. Park BG, Cho KI, Cho KR. Two cases of tonic pupil. J Korean Ophthalmol Soc. 1981; 22:267–71.
7. Park JS, Park JM, Lee JE, Oum BS. Vogt-Koyanagi-Harada dis-ease associated with bilateral tonic pupils in a pregnant patient. J Korean Ophthalmol Soc. 2007; 48:1588–92.
crossref
8. Lee KS, Choi HJ, Kim HY. A case of Adie’s tonic pupil before pre-sentation of denervation hypersensitivity. J Korean Ophthalmol Soc. 2008; 49:2032–6.
crossref
9. Adie WJ. Complete and incomplete forms of the benign disorder characterised by tonic pupils and absent tendon reflexes. Br J Ophthalmol. 1932; 16:449–61.
crossref
10. Thompson HS. Segmental palsy of the iris sphincter in Adie’s syndrome. Arch Ophthalmol. 1978; 96:1615–20.
crossref
11. Kardon RH, Corbett JJ, Thompson HS. Segmental denervation and reinnervation of the iris sphincter as shown by infrared video-graphic transillumination. Ophthalmology. 1998; 105:313–21.
crossref
12. Adler FH, Scheie HG. The site of the disturbance in tonic pupils. Trans Am Ophthalmol Soc. 1940; 38:183–92.
13. Leavitt JA, Wayman LL, Hodge DO, Brubaker RF. Pupillary re-sponse to four concentrations of pilocarpine in normal subjects: application to testing for Adie tonic pupil. Am J Ophthalmol. 2002; 133:333–6.
crossref
14. Younge BR, Buski ZJ. Tonic pupil: a simple screening test. Can J Ophthalmol. 1976; 11:295–9.
15. Jacobson DM, Olson KA. Influence of pupil size, anisocoria and ambient light on pilocarpine miosis; implications for super-sensitivity testing. Ophthalmology. 1993; 100:275–80.
16. Ramsay DA. Dilute solutions of phenylephrine and pilocarpine in the diagnosis of disordered autonomic innervation of the iris. Observations in normal subjects, and in the syndromes of Horner and Holmes-Adie. J Neurol Sci. 1986; 73:125–34.
crossref
17. Jacqueline A, Leavitt, MD. Pilocarpine diagnoses Adie’s tonic pupil. Am J Ophthalmol. 2002; 133:333–6.
18. Bourgon P, Pilley FJ, Thompson HS. Cholinergic supersensitivity of the iris sphincter in Adie’s tonic pupil. Am J Ophthalmol. 1978; 85:373–7.
crossref
19. Jacobson DM, Vierkant RA. Comparison of cholinergic super-sensitivity in third nerve palsy and Adie's syndrome. J Neuroo- phthalmol. 1998; 18:171–5.
crossref
20. Koh JK, Kim J, Ryu HJ, et al. A case of rheumatoid arthritis with Sjogren’s syndrome presenting as a tonic pupil. Korean J Med. 2009; 77:261–4.
21. Camoriano GD, Kassab J, Suchak A, Gimbel HV. Neurosyphilis masquerading as an acute Adie’s tonic pupil: report of a case. Case Rep Ophthalmol. 2011; 2:205–10.
crossref
22. Bell RA, Thompson HS. Ciliary muscle dysfunction in Adie’s syndrome. Arch Ophthalmol. 1978; 96:638–42.
crossref
23. Lepore FE. Diagnostic pharmacology of the pupil. Clin Neuro- pharmacol. 1985; 8:27–37.
crossref
24. Thompson S, Pilley SF. Unequal pupils. A flowchart for sorting out the anisocorias. Surv Ophthalmol. 1976; 21:45–8.
25. Flach AJ, Dolan BJ. The therapy of Adie’s syndrome with dilute pilocarpine hydrochloride solutions. J Ocul Pharmacol. 1985; 1:353–62.
crossref
26. Holmes G. Partial iridoplegia associated with symptoms of other diseases of the nervous system. Trans Ophthalmol Soc UK. 1931; 51:209–28.
27. Rosenberg ML. Miotic Adie’s pupils. J Clin Neuroophthalmol. 1989; 9:43–5.
28. Purcell JJ Jr, Krachmer JH, Thompson HS. Corneal sensation in Adie’s syndrome. Am J Ophthalmol. 1977; 84:496–500.
crossref

Figure 1.
Differences of pupil size between Adie’s tonic pupils and fellow eyes under variable conditions.
jkos-54-777f1.tif
Figure 2.
Comparison of light-near dissociation between Adie’s tonic pupils and fellow eyes.
jkos-54-777f2.tif
Figure 3.
Patients number of iris segmental palsies for each clock hour of the affected sphincter.
jkos-54-777f3.tif
Figure 4.
Number of patients according to the regions of de-creased corneal sensation.
jkos-54-777f4.tif
Figure 5.
Denervation supersensitivity test: The serial changes of Adie’s tonic pupils at the baseline, 10, 20 and 30 minutes af-ter 0.125% pilocarpine instillation.
jkos-54-777f5.tif
Figure 6.
Comparison of deep tendon reflex between Adie’s tonic pupil patients and control group.
jkos-54-777f6.tif
Table 1.
Age at onset of study population
Age at onset (years) Number of patients
10-19 1
20-29 3
30-39 9
40-49 4
50-59 3
60-69 2
Table 2.
Pupil size of Adie’s tonic pupils and fellow eyes un-der room light
Pupil size (mm) Affected eye (No. of eyes) Fellow eye (No. of eyes)
3.0-3.9 0 7
4.0-4.9 0 7
5.0-5.9 6 4
6.0-6.9 7 1
7.0-7.9 5 0
8≤ 1 0

We excluded bilateral Adie’s tonic pupil. No. = number.

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