Journal List > J Korean Ophthalmol Soc > v.54(5) > 1009674

Jung, Jung, and Sang: The Study of Ocular Side Effects after the Use of Anti-Glaucoma Topical Medication

Abstract

Purpose

To investigate the influence of number and type of side effects as well as treatment period after the use of an-ti-glaucoma eye drops in patients with glaucoma.

Methods

A survey was conducted regarding the severity of ocular side effects after the use of anti-glaucoma eye drops in 528 patients with glaucoma. Side effects after using the eye drops included irritability, blurred vision, foreign body sensa-tion, hyperemia, pinpricking sensation, itching, discomfort, pain, tearing, dry eye, and pigmentation. We analyzed the re-sults to investigate the influence of number and type of side effects as well as treatment period.

Results

The side effects after the use of anti-glaucoma eye drops were more severe and frequent in the patient groups us-ing more than 1 eye drop ( p < 0.01) and in the patients with longer treatment period ( p < 0.01). Among patients using 1 eye drops, side effects developed frequently in patients using Ocucarpine®.

Conclusions

In patients with glaucoma, using more than 1 anti-glaucoma eye drop or having a longer treatment period re-sulted in more side effects. Similaryly, patients using only 1 eye drop of Ocu-carpine® induced more side effects.

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Figure 1.
A questionnaire about side effects that occurred after the use of anti-glaucoma eye drops.
jkos-54-745f1.tif
Figure 2.
The influence of number of anti-glaucoma eye drops. * Statistically significant, p < 0.05.
jkos-54-745f2.tif
Figure 3.
The influence of type of anti-glaucoma eye drops in the one eye drop group. * Statistically significant, p < 0.05.
jkos-54-745f3.tif
Figure 4.
The influence of treatment periods in the one eye drop group in Alphagan® (A), Combigan® (B), Cosopt® (C), Duotrav®(D), Elazop® (E), Ocucarpine® (F), Taflotan® (G), Travatan® (H), and Xalatan® (I) group (M = month; Y = year). * Statistically significant, p < 0.05.
jkos-54-745f4.tif
Figure 5.
The influence of type of anti-glaucoma eye drops in the two eye drops group.
jkos-54-745f5.tif
Figure 6.
The influence of type of anti-glaucoma eye drops in the three eye drops group.
jkos-54-745f6.tif
Figure 7.
The influence of treatment periods. * Statistically sig-nificant, p < 0.05.
jkos-54-745f7.tif
Table 1.
Demographics of patients use anti-glaucoma eye drops for glaucoma
Characteristics Value
Age (years) 60.40 ± 13.12
Sex
Men (%) 257/528 (48.7)
Women (%) 271/528 (51.3)
Use medicine (%)
One
Alphagan® 33/313 (10.5)
Combigan® 29/313 (9.3)
Cosopt® 80/313 (25.6)
Duotrav® 12/313 (3.8)
Elazop® 14/313 (4.5)
Ocucarpine® 13/313 (4.2)
Taflotan® 63/313 (20.1)
Travatan® 22/313 (7.0)
Xalatan® 47/313 (15.0)
Two
Alphagan®/Cosopt® 20/147 (13.6)
Combigan®/Xalatan® 15/147 (10.2)
Cosopt®/Taflotan® 22/147 (15.0)
Cosopt®/Travatan® 13/147 (8.8)
Cosopt®/Xalatan® 53/147 (36.1)
Elazop®/Taflotan® 11/147 (7.5)
Elazop®/Xalatan® 13/147 (8.8)
Three
Alphagan®/Cosopt®/Xalatan® 16/68 (23.5)
Alphagan®/Cosopt®/Travatan® 52/68 (76.5)

Values are presented as mean ± SD or number (%).

Table 2.
Severity of side effects related with types and treatments periods in the one eye drop group
<1 month 1 month to 3 months 3 months to 1 year >1 year Total
Patients Score Patients Score Patients Score Patients Score Patients Score
Alphagan® 21 0.49 ± 0.74 6 0.79 ± 1.26 4 1.76 ± 1.71 2 3.53 ± 0.71 33 0.88 ± 1.43
Combigan® 19 0.49 ± 0.68 2 1.55 ± 1.41 5 1.55 ± 1.58 3 1.80 ± 2.31 29 0.88 ± 1.35
Cosopt® 34 1.18 ± 1.53 17 1.94 ± 1.60 20 2.90 ± 2.13 9 4.33 ± 3.77 80 2.13 ± 2.26
Duotrav® 6 0.64 ± 0.75 2 1.55 ± 0.71 2 1.93 ± 0.71 2 2.71 ± 2.12 12 1.42 ± 1.68
Elazop® 6 0.67 ± 0.82 4 1.75 ± 2.87 2 3.00 ± 0.00 2 5.50 ± 0.71 14 2.00 ± 2.25
Ocucarpine® 7 1.00 ± 0.58 2 3.50 ± 2.12 2 3.00 ± 2.83 2 9.00 ± 1.41 13 2.92 ± 3.12
Taflotan® 32 0.88 ± 0.97 12 1.67 ± 1.64 7 2.34 ± 3.15 12 2.58 ± 1.85 63 1.52 ± 1.83
Travatan® 14 0.36 ± 1.16 3 0.96 ± 0.58 2 2.52 ± 0.71 3 3.36 ± 0.58 22 1.05 ± 1.59
Xalatan® 18 0.59 ± 0.57 14 1.53 ± 1.29 9 1.65 ± 1.41 6 1.78 ± 2.40 47 1.23 ± 1.49

Values are presented as number or mean ± SD.

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