Lattice Corneal Dystrophy, Gelsolin Type: The First Case Report in Korea

Tae Hyup Kim; Ji Hyun Bae; Dong Hui Lim; Eui Sang Chung; Tae Young Chung

doi:10.3341/jkos.2013.54.4.667

Journal List > J Korean Ophthalmol Soc > v.54(4) > 1009659

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Kim, Bae, Lim, Chung, and Chung: Lattice Corneal Dystrophy, Gelsolin Type: The First Case Report in Korea

Original Article

J Korean Ophthalmol Soc 2007;54(4):667-670.

Published online: 24 August 2007

DOI: https://doi.org/10.3341/jkos.2013.54.4.667

Lattice Corneal Dystrophy, Gelsolin Type: The First Case Report in Korea

Tae Hyup Kim, MD, Ji Hyun Bae, MD, Dong Hui Lim, MD, Eui Sang Chung, MD, PhD, Tae Young Chung, MD, PhD

Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

Address reprint requests to Tae Young Chung, MD, PhD Department of Ophthalmology, Samsung Medical Center #81 Irwon-ro, Gangnam-gu, Seoul 135-710, Korea Tel: 82-2-3410-3569, Fax: 82-2-3410-0074, E-mail: tychung@skku.edu

Received 11 May 201220 August 2012 Accepted 13 March 2013

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

To report the first case of lattice corneal dystrophy, gelsolin type in Korea.

Case summary

A 61-year-old man visited our clinic with severe dry eye symptom in both eyes. Clinical examination revealed in both eyes a visual acuity of 0.7 without correction and intraocular pressure of 18 mm Hg. On slit-lamp examination, both corneas had scattered lattice lines at various depths within the stroma with punctate epithelial erosions. The patient had characteristic features of Meretoja syndrome, including cranial neuropathy characterized by dermatochalasis and facial weakness, and was positive for the gelsolin mutation according to DNA analysis. This is the first description of a patient with lattice corneal dystrophy, gelsolin type in Korea.

Conclusions

This is the first description of a patient with lattice corneal dystrophy, gelsolin type in Korea and demonstrates the importance of recognizing the systemic and ophthalmic features for appropriate management of the condition.

J Korean Ophthalmol Soc 2013;54(4):667-670

Keywords: Amyloidosis, Gelsolin, Lattice corneal dystrophy, Meretoja syndrome

References

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Figure 1.

Photograph of the anterior cornea illustrating stromal lattice deposits. Lattice lines are seen centrally.

Figure 2.

Clinical photographs illustrating a smooth brow, drooping face, and protuberant lip.

Figure 3.

Direct sequencing of the GSN gene in the patient. A heterozygous missense mutation was identified in the patient: c.654G > T (p.Asp214Tyr) (arrow).

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