Eccrine Ductal Carcinoma Arising in the Eyelid

Tae Hyup Kim; Jung Hye Lee; Jung Hyun Ahn; Kyung In Woo; Yeon Lim Suh; Yoon Duck Kim

doi:10.3341/jkos.2013.54.4.651

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Kim, Lee, Ahn, Woo, Suh, and Kim: Eccrine Ductal Carcinoma Arising in the Eyelid

Original Article

J Korean Ophthalmol Soc 2007;54(4):651-654.

Published online: 24 August 2007

DOI: https://doi.org/10.3341/jkos.2013.54.4.651

Eccrine Ductal Carcinoma Arising in the Eyelid

Tae Hyup Kim, MD¹, Jung Hye Lee, MD¹, Jung Hyun Ahn, MD¹, Kyung In Woo, MD, PhD¹, Yeon Lim Suh, MD, PhD², Yoon Duck Kim, MD, PhD¹

¹Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

²Department of Pathology, Samsung Medical Cente, Sungkyunkwan University School of Medicine, Seoul, Korea

Address reprint requests to Yoon Duck Kim, MD, PhD Department of Ophthalmology, Samsung Medical Center #81 lrwon-ro, Gangnam-gu, Seoul 135-710, Korea Tel: 82-2-3410-3561, Fax: 82-2-3410-0074, E-mail: ydkim@smc.samsung.co.kr

Received 3 August 201222 August 2012 Accepted 13 March 2013

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

Eccrine ductal carcinoma is an extremely rare tumor that arises in the eccrine sweat glands. The authors of the present study describe a case of an eyelid mass diagnosed as eccrine ductal carcinoma.

Case summary

A 74-year-old woman visited our institute with a 3-month history of a mass in the left medial canthus. The lesion appeared as a solitary nodule with central ulceration. A magnetic resonance imaging (MRI) of the orbit showed a relatively well enhanced 0.8 cm × 0.8 cm-sized ovoid soft tissue mass. A mass excision was performed under frozen section control. The tumor was completely excised with margin clearance and medial canthal reconstruction was performed. Histopathological examination revealed a tumor composed of numerous duct-like structures lined with pleomorphic cuboidal epithelium that was diagnosed as eccrine ductal carcinoma of the eyelid.

Conclusions

This is the first description of eccrine ductal carcinoma in a patient in Korea. The possibility of the eccrine ductal carcinoma should be considered in the differential diagnosis in an elderly patient with an eyelid mass.

J Korean Ophthalmol Soc 2013;54(4):651-654

Keywords: Eccrine ductal carcinoma, Eyelid tumor, Sweat gland tumor

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Figure 1.

Clinical photograph showing a firm mass with central ulceration in the medial canthal area of the left eye.

Figure 2.

(A) T1-weighted axial image demonstrating a poorly marginated mass with low signal intensity. (B) T2-weighted axial image demonstrating a heterogeneous high signal intensity in the left medial canthal area. (C) Contrast enhanced T1-weighted images demonstrating a relatively well enhancing soft tissue mass in the left medial canthal area.

Figure 3.

(A) Intraoperative photography showing a widely excised lesion with large defect. (B) A medial canthal reconstruction using advancement flap.

Figure 4.

Low-power magnification of tumor shows numerous duct-like structures lined by cuboidal epithelium (hematoxylin and eosin, ×;100).

Figure 5.

High-power magnification reveals frequent mitotic figures and nuclear pleomorphism (hematoxylin and eosin, ×;400).

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