The Effects of Pharmacologic Pupil Dilatation on Ocular, Corneal, and Internal Aberrations

Eun Joo Yoo; Su Yeon Kang; Hyo Myung Kim; Jong Suk Song

doi:10.3341/jkos.2013.54.4.581

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Yoo, Kang, Kim, and Song: The Effects of Pharmacologic Pupil Dilatation on Ocular, Corneal, and Internal Aberrations

Original Article

J Korean Ophthalmol Soc 2007;54(4):581-586.

Published online: 24 August 2007

DOI: https://doi.org/10.3341/jkos.2013.54.4.581

The Effects of Pharmacologic Pupil Dilatation on Ocular, Corneal, and Internal Aberrations

Eun Joo Yoo, MD, Su Yeon Kang, MD, Hyo Myung Kim, MD, PhD, Jong Suk Song, MD, PhD

Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea

Address reprint requests to Jong Suk Song, MD, PhD Department of Ophthalmology, Korea University Curo Hospital #148 Gurodong-ro, Guro-gu, Seoul 152-703, Korea Tel: 82-2-2626-3178, Fax: 82-2-857-8580, E-mail: crisim@korea.ac.kr

Received 30 April 201223 July 2012 Accepted 15 February 2013

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

The present study investigates the effects of pharmacologic pupil dilatation on ocular, corneal and internal aberrations.

Methods

Sixty-two right eyes of 62 healthy participants were included in the present study. Ocular, corneal and internal aberrations were measured with a KR-1W wavefront aberrometer (Topcon Corp., Tokyo, Japan) before mydriasis in mesopic conditions. After pupil dilatation with a mydriatic drug (phenylephrine chloride 0.5% + tropicamide 0.5%) (Mydrin-P, Santen, Osaka, Japan), the measurements were repeated. The wavefront data of 4-mm and 6-mm diameter zones were analyzed. The changes of aberrations before and after mydriasis were evaluated by paired t-test.

Results

The values of ocular, corneal and internal spherical aberrations before and after mydriasis on the 4-mm diameter pupil zone were not statistically significantly different. On the 6-mm diameter zone, the ocular and internal spherical aberrations were statistically significantly different (p = 0.025, p = 0.002, respectively, paired t-test). However, the corneal aberrations did not show significant changes. The internal aberrations average before mydriasis was -0.043 (±0.21) μm and was shifted in a negative direction to -0.093 (±0.17) μm after mydriasis. The ocular aberrations average also changed toward negative after mydriasis. The high-order aberrations and astigmatism did not change significantly.

Conclusions

The ocular and internal spherical aberrations changed toward negative with mydriasis in the participants' eyes suggesting the change of the ocular spherical aberration to be attributed to internal changes.

Keywords: Aberrations, KR-1W, Mydriasis

References

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Figure 1.

Comparison of spherical aberrations (SA) before and after mydriasis (in micrometer). The ocular and internal spherical aberrations were statistically significantly different on 6-mm diameter zone (p = 0.025, p = 0.002, respectively, paired t-test). Before = before mydriasis, at mesopic conditions, 8 lux; After = after pharmacologically induced mydriasis.

Figure 2.

Comparison of high order aberrations (HOA) before and after mydriasis (in average root mean square; RMS). The high order aberrations did not change significantly after mydriasis. Before = before mydriasis, at mesopic conditions, 8 lux; After = after pharmacologically induced mydriasis.

Figure 3.

Comparison of astigmatism (Astig.) before and after mydriasis (in diopter). The astigmatism did not change significantly after mydriasis. Before = before mydriasis, at mesopic conditions, 8 lux; After = after pharmacologically induced mydriasis.

Table 1.

The average of ocular, corneal and internal spherical aberrations on 4-mm and 6-mm diameter zone before and after mydriasis. The ocular and internal spherical aberrations on 6-mm diameter zone were statistically significantly shifted in a negative direction after mydriasis

Pupil size	Before^* (μm)	After^† (μm)	p-value
4-mm	Ocular SA	0.037 ± 0.035	0.038 ± 0.039	0.857
	Corneal SA	0.052 ± 0.029	0.056 ± 0.029	0.343
	Internal SA	-0.014 ± 0.037	-0.019 ± 0.032	0.228
6-mm	Ocular SA	0.26 ± 0.25	0.23 ± 0.25	0.025
	Corneal SA	0.29 ± 0.21	0.32 ± 0.18	0.088
	Internal SA	-0.043 ± 0.21	-0.093 ± 0.17	0.002

Values are presented as mean ± SD.

SA = spherical aberrations.

^* Before mydriasis, at mesopic conditions, 8 lux

^† After pharmacologically induced mydriasis.

Table 2.

The average of ocular, corneal and internal high order aberrations on 4-mm and 6-mm diameter zone before and after mydriasis. The high order aberrations were not statistically significantly different after mydriasis

Pupil size	Before^* (RMS^‡)	After^† (RMS)	p-value
4-mm	Ocular HOA	0.16 ± 0.084	0.16 ± 0.089	0.906
	Corneal HOA	0.16 ± 0.071	0.15 ± 0.061	0.241
	Internal HOA	0.13 ± 0.098	0.13 ± 0.097	0.945
6-mm	Ocular HOA	0.54 ± 0.33	0.52 ± 0.33	0.139
	Corneal HOA	0.48 ± 0.26	0.48 ± 0.26	0.921
	Internal HOA	0.42 ± 0.24	0.39 ± 0.21	0.267

Values are presented as mean ± SD. HOA = high order aberrations.

^* Before mydriasis, at mesopic conditions, 8 lux

^† After pharmacologically induced mydriasis

^‡ Average root mean square.

Table 3.

The average of ocular, corneal and internal astigmatism on 4-mm and 6-mm diameter zone before and after mydriasis. The astigmatism was not statistically significantly different after mydriasis

Pupil size	Before^* (D)	After^† (D)	p-value
4-mm	Ocular Astig.	-0.86 ± 0.49	-0.85 ± 0.46	0.936
	Corneal Astig.	-0.83 ± 0.54	-0.80 ± 0.54	0.409
	Internal Astig.	-0.65 ± 0.37	-0.70 ± 0.39	0.229
6-mm	Ocular Astig.	-0.92 ± 0.49	-0.95 ± 0.55	0.417
	Corneal Astig.	-0.65 ± 0.43	-0.63 ± 0.47	0.579
	Internal Astig.	-0.66 ± 0.39	-0.69 ± 0.43	0.427

Values are presented as mean ± SD. D = Diopters; Astig. = Astigmatism.

^* Before mydriasis, at mesopic conditions, 8 lux

^† After pharmacologically induced mydriasis.

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