The Effects of Intralesional Steroid Injection for Chalazion According to the Concentrations of Triamcinolone Acetonide

Joo Kim Eun; Yu Sung; Jin Jeong Byung; Won Lee Kyoo; Jae Mun Hong

doi:10.3341/jkos.2013.54.3.396

Journal List > J Korean Ophthalmol Soc > v.54(3) > 1009611

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Eun, Sung, Byung, Kyoo, and Hong: The Effects of Intralesional Steroid Injection for Chalazion According to the Concentrations of Triamcinolone Acetonide

Original Article

J Korean Ophthalmol Soc 2007;54(3):396-400.

Published online: 24 August 2007

DOI: https://doi.org/10.3341/jkos.2013.54.3.396

The Effects of Intralesional Steroid Injection for Chalazion According to the Concentrations of Triamcinolone Acetonide

Joo Kim Eun, MD, Yu Sung, MD, Jin Jeong Byung, MD, Won Lee Kyoo, MD, Jae Mun Hong, MD

Cheil Eye Hospital, Daegu, Korea

Address reprint requests to Hong Jae Mun, MD Cheil Eye Hospital #1 Ayang-ro, Dong-gu, Daegu 701-820, Korea Tel: 82-53-959-1751, Fax: 82-53-959-1758, E-mail: drmhj92@hanmail.net

Received 26 July 2006 Accepted 8 May 2007

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

To compare the efficacy of an intralesional steroid injection in the treatment of chalazion according to triamcinolone acetonide (TA) concentrations.

Methods

A total of 108 patients with 120 chalazia received an intralesional injection of TA. Patients were divided into 3 groups according to the concentrations of TA: 5 mg/ml, 10 mg/ml, and 40 mg/ml. A regular follow-up was performed and the size of lesion and recurrence were evaluated.

Results

Success was defined as a minimum of 80% decrease in size with no recurrence. The success rate was 78.1% in the 5 mg/ml group, 76.2% in the 10 mg/ml group, and 78.4% in the 40 mg/ml group. These results were not statistically significant (p = 0.999, Fisher's exact test). Yellow deposits developed in 4 out of 37 lesions in the 40mg/ml group, and in 1 out of 42 lesions in the 10 mg/ml group. Skin depigmentation was observed in 1 case in the 5 mg/ml group.

Conclusions

Intralesional TA injection is an effective treatment for chalazion. There is no significant difference in success rates according to the concentrations of TA. However, caution is advised in cases of high injection concentrations of TA to prevent yellow deposits.

Keywords: Chalazion, Intralesional injection, Triamcinolone acetonide

References

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Figure 1.

Yellow deposit at the injection site of the 40 mg/ml triamcinolone acetonide.

Table 1.

Demographics of patients diagnosed with chalazion

Number of lesions (patients)	120 (108)
Age (years)	22.0 ± 18.2
Sex (n)
Male	53
Female	67
Duration of chalazion (months)	1.6 ± 1.5
Location, eyes (n)
Right upper lid	40
Right lower lid	21
Left upper lid	37
Left lower lid	22
Follow-up (months) (range)	4.0 ± 6.6 (3-24)

Values are presented as mean ± SD or n.

SD = standard deviation.

Table 2.

Demographics according to the concentrations of triamcinolone acetonide

	5 mg/ml	10 mg/ml	40 mg/ml	p-value
Number of lesions	41	42	37
Mean age (years)	25.4 ± 17.9	20.6 ± 20.4	20.0 ± 15.6	0.162^%
Sex (n)
Male	18	14	21	0.124^†
Female	23	28	16

Values are presented as mean ± SD or n.

SD = standard deviation.

^* Kruskall-Wallis test;

^† Fisher's exact test.

Table 3.

Treatment outcome according to the concentrations of triamcinolone acetonide (TA)

Concentration of TA	Success rates, lesions (%)	p-value^*
5 mg/ml	32/41 (78.1)
10 mg/ml	32/42 (76.2)	0.999
40 mg/ml	29/37 (78.4)
Total	93/120 (77.5)

^* Fisher's exact test.

Table 4.

The number of lesions that developed yellow deposits according to the concentrations of triamcinolone acetonide (TA)

Concentration of TA	The number of yellow deposits (%)	p-value^*
5 mg/ml	0/41 (0)
10 mg/ml	1/42 (2.1)	0.039
40 mg/ml	4/37 (10.8)
Total	5/120 (4.2)

^* Fisher's exact test.

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