A Case of Rosai-Dorfman Disease Affecting the Palpebral Conjunctiva

Jae Yeun Lee; Hyun Min Shin; Helen Lew

doi:10.3341/jkos.2013.54.2.346

Journal List > J Korean Ophthalmol Soc > v.54(2) > 1009601

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Lee, Shin, and Lew: A Case of Rosai-Dorfman Disease Affecting the Palpebral Conjunctiva

Original Article

J Korean Ophthalmol Soc 2007;54(2):346-350.

Published online: 24 August 2007

DOI: https://doi.org/10.3341/jkos.2013.54.2.346

A Case of Rosai-Dorfman Disease Affecting the Palpebral Conjunctiva

Jae Yeun Lee, MD, Hyun Min Shin, MD, Helen Lew, MD

Department of Ophthalmology, CHA Bundang Medical Center, CHA University, Seongnam, Korea

Address reprint requests to Helen Lew, MD, Department of Ophthalmology, CHA University Bundang CHA Medical Center, #59 Yatap-ro, Bundang-gu, Seongnam 463-712, Korea Tel: 82-31-780-5330, Fax: 82-31-780-5333, E-mail: eye@cha.ac.kr

Received 10 March 201217 April 2012 Accepted 18 August 2012

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

To report a single case of Rosai-Dorfman disease of the palpebral conjunctiva with a review of the relevant literature.

Case summary

A 39-years-old woman presented with a palpebral conjunctival mass 3 weeks in duration on both eyes. The patient had a history of excisional biopsy of lymphadenitis and wanted to remove the mass for cosmetic reasons. An excisional biopsy was performed to obtain a diagnosis for proper management. The histopathologic examination of the lesion showed an intensive proliferation of monotonous and histiocytoid cells beneath the epidermis. Immunohistochemical staining for the S-100 protein was positive and anti-CD1A antibody was negative. Five months after mass excision, there was no evidence of recurrence.

Keywords: Conjunctival mass, Palpebral conjunctiva, Rosai-Dorfman disease

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Figure 1.

The photograph of the patient's eye before excisional biopsy. Hyperemic and smooth surfaced 25 × 10 mm sized mass was noted at the palpebral conjunctiva of right lower lid.

Figure 2.

Computed tomographic findings. About 2.8-cm enlarged lymph node (arrow) at the right lateral retropharyngeal space. (A) Small enhancing solid nodule (arrow) at the left nasal cavity (B).

Figure 3.

Medium power image demonstrating sinus histiocytosis (arrow) with massive lymphadenopathy (H&E, original magnification ×200).

Figure 4.

M edium power image demonstrating scattered strongly S-100 positive histiocytes within the inflammatory infiltration (S-100, original magnification ×200).

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