Analysis of Retinal Nerve Fiber Layer Thickness of Superior Segmental Optic Hypoplasia and Normal-Tension Glaucoma

Joo Hyun Kim; Shin Hee Kang; Joo Hyun Park; Kayoung Yi

doi:10.3341/jkos.2013.54.2.331

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Kim, Kang, Park, and Yi: Analysis of Retinal Nerve Fiber Layer Thickness of Superior Segmental Optic Hypoplasia and Normal-Tension Glaucoma

Original Article

J Korean Ophthalmol Soc 2007;54(2):331-337.

Published online: 24 August 2007

DOI: https://doi.org/10.3341/jkos.2013.54.2.331

Analysis of Retinal Nerve Fiber Layer Thickness of Superior Segmental Optic Hypoplasia and Normal-Tension Glaucoma

Joo Hyun Kim, MD, Shin Hee Kang, MD, Joo Hyun Park, MD, Kayoung Yi, MD, PhD

Department of Ophthalmology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea

Department of Ophthalmology, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, Korea

Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea

Address reprint requests to Kayoung Yi, MD, PhD Department of Ophthalmology, Hallym University Kangnam Sacred Heart Hospital #1 Singil-ro, Yeongdeungpo-gu, Seoul 150-950, Korea Tel: 82-2-829-5193, Fax: 82-2-848-4638, E-mail: kayoungyi@yahoo.co.kr

Received 30 March 201211 October 2012 Accepted 2 January 2013

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

To analyze the peripapillary retinal nerve fiber layer (RNFL) in superior segmental optic hypoplasia (SSOH) patients and normal tension glaucoma (NTG) patients with inferior visual field defects using optical coherence tomography (OCT).

Methods

Ten eyes of 10 patients with SSOH and 10 eyes of 10 patients with NTG were evaluated. The peripapillary RNFL thickness measured by OCT was compared between the 2 groups.

Results

The mean RNFL thickness was not significantly different between SSOH patients (79.60 ± 12.54 μm) and NTG patients (77.10 ± 8.52 μm) (p = 0.089). Among the quadrant parameters, there were no significant differences between the 2 groups (p > 0.05). In a clock-hour analysis, the peripapillary RNFL thickness of the NTG group was significantly thicker than the SSOH group in 12, 1, and 2 o'clock (p = 0.029, 0.007, 0.043, respectively). In contrast, the peripapillary RNFL thickness of the SSOH group was significantly thicker than the SSOH group in 6, and 7 o'clock (p = 0.029, 0.007, respectively). Conclusions: Peripapillary RNFL thickness in patients with SSOH was thinner than in those with NTG in the superonasal region, but thicker in the inferotemporal region indicating a different retinal nerve fiber defect pattern between the 2 diseases.

Keywords: Nerve hypoplasia, Optic hypoplasia, Optic nerve, Superior segmental optic hypoplasia (SSOH)

References

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Figure 1.

A patient with superior segmental optic hypoplasia (SSOH). Representative color disc photograph (A) and retinal nerve fiber layer (RNFL) photograph (B) showing neuroretinal thinning of the superior nasal region with corresponding RNFL defects. (C) Humphrey automated perimetry shows a characteristic inferior visual field defect. (D) Optical coherence tomography (OCT) scan shows the peripapillary RNFL thinning in superior region of the left eye.

Figure 2.

Three examples with superior segmental optic hypoplasia (SSOH). Color fundus photograph and retinal nerve fiber layer (RNFL) photograph show optic disc rim thinning in the superior and superonasal segments (A, B, C).

Figure 3.

The peripapillary retinal nerve fiber layer (RNFL) thickness assessed by optical coherence tomography is shown for clock hour around the optic nerve head. Solid triangles represent mean RNFL thickness from 10 eyes with superior segmental optic hypoplasia (SSOH) and solid squares represent normal tension glaucoma (NTG) patients. Error bars indicate 1 standard deviation from the mean. Asterisks indicate the clock hours that show significant difference of RNFL thickness between NTG and SSOH patients (p < 0.05).

Table 1.

Demographics of the subjects

	SSOH	NTG	p-value
No. of patients (eyes)	10 (10)	10 (10)
Gender (male : female)	4 : 6	6 : 4	0.656*
Age (years)	48.9 ± 10.5	54.1 ± 14.8	0.631^†
SE (diopter)	-1.4 ± 2.0	-0.2 ± 2.4	0.218
Visual acuity (decimal)	0.9 ± 0.1	0.9 ± 0.1	0.529

Values are presented as mean ± SD.

SSOH = superior segmental optic hypoplasia; SE = spherical equivalent.

^* Pearson chi-square test

^† Mann-Whitney U test.

Table 2.

Characteristics of 10 superior segmental optic hypoplasia patients

BCVA (decimal)	0.9 ± 0.1	Ophthalmologic findings
IOP (mm Hg)	17.1 ± 2.9	Superior enterance of CRA	7
Family history	0	Superior sclera halo	5
Maternal DM	0	Thinning of superior RNFL	10
		Thinning of Inferior RNFL	4

Values are presented as mean ± SD.

BCVA = best corrected visual acuity; CRA = central retinal artery; RNFL = retinal nerve fiber layer.

Table 3.

Comparison of VF and RNFL parameters between the SSOH group and NTG group

Parameter	SSOH group	NTG group	p-value
Visual field
Mean deviation (range, dB)	-3.26 ± 1.76	-3.94 ± 2.03	0.481
	(-1.84 ~ −6.88)	(-2.28 ~ −7.42)
Pattern standard deviation (range, dB)	5.45 ± 3.66	6.22 ± 2.90	0.123
	(2.43 – 10.43)	(3.04 – 11.85)
RNFL analysis
Average (μm)	79.60 ± 12.54	77.10 ± 8.52	0.089
Superior (μm)	82.60 ± 20.34	90.30 ± 18.15	0.393
Nasal (μm)	58.30 ± 12.11	58.80 ± 4.54	0.971
Inferior (μm)	103.10 ± 28.03	97.90 ± 15.27	0.631
Temporal (μm)	75.40 ± 23.62	61.50 ± 10.15	0.247

Values are presented as mean ± SD.

VF = visual field; RNFL = retinal nerve fiber layer; SSOH = superior segmental optic hypoplasia; NTG = normal tension glaucoma. Mann-Whitney U Test.

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